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Scavenger Receptors and Atherosclerosis

Biological Research, 2000
Scavenger receptors were discovered as cell surface proteins capable of binding and internalization of modified lipoproteins. These receptors exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands ...
ATTILIO RIGOTTI
doaj   +8 more sources

The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]

Frontiers in Immunology, 2015
The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Dawn Bowdish, Fiona Jane Whelan, G Brian Golding   +2 more
exaly   +7 more sources

The evolution of the class A scavenger receptors [PDF]

BMC Evolutionary Biology, 2012
Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising ...
Whelan Fiona J, Meehan Conor J, Golding G Brian, McConkey Brendan J, E Bowdish Dawn M   +4 more
doaj   +6 more sources

The Scavenger Function of LSECs, a Regulator of Liver Diseases [PDF]

Current Issues in Molecular Biology
Liver sinusoidal endothelial cells are highly specialized endothelial cells that contribute to liver homeostasis through their remarkable scavenger function.
Juntao Zhou, Lijuan Zhang, Jianqiao Wang, Chengliang Zhang, Cheng Tian   +4 more
doaj   +2 more sources

Standardizing Scavenger Receptor Nomenclature [PDF]

The Journal of Immunology, 2014
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
PrabhuDas, Mercy, Bowdish, Dawn, Drickamer, Kurt, Febbraio, Maria, Herz, Joachim, Kobzik, Lester, Krieger, Monty, Loike, John D., Means, Terry K., Moestrup, Soren K., Post, Steven, Sawamura, Tatsuya, Silverstein, Samuel C., Wang, Xiang-Yang, El Khoury, Joseph   +14 more
openaire   +5 more sources

Macrophage scavenger receptors: Tumor support and tumor inhibition [PDF]

Frontiers in Oncology, 2023
Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a ...
Elena Kazakova, Elena Kazakova, Pavel Iamshchikov, Pavel Iamshchikov, Irina Larionova, Irina Larionova, Irina Larionova, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska   +10 more
doaj   +4 more sources

Scavenger receptors in host defense: from functional aspects to mode of action [PDF]

Cell Communication and Signaling, 2022
Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq, Syed Mudasir Ahmad   +4 more
doaj   +2 more sources

Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

International Journal of Hypertension, 2010
Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of ...
Sam L. Stephen, Katie Freestone, Sarah Dunn, Michael W. Twigg, Shervanthi Homer-Vanniasinkam, John H. Walker, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +7 more
doaj   +2 more sources

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Journal of Lipid Research, 2005
Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in
David R. Greaves, Siamon Gordon
doaj   +2 more sources

Interaction of Human Lymphocyte Scavenger Receptors CD5 and CD6 with Toxins from Naja haje, Androctonus australis and Apis mellifera Venoms [PDF]

Biomolecules
Animal venoms induce systemic inflammatory response syndrome through their interaction, inter alia, with pattern recognition receptors (PRRs) of the innate immune system.
Dalila Khemili, Laura Carrillo-Serradell, Violeta Planells-Romeo, Lucía Aragón-Serrano, Selma Djilani, Djelila Hammoudi-Triki, Khedidja Zerouti, Abdenacer Mouffok, Francisco Lozano, María Velasco-de-Andrés   +9 more
doaj   +2 more sources