Results 31 to 40 of about 15,256,107 (329)

A gut feeling for drugs that have metabolic benefits

Nature Communications, 2023
Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors.
Eryun Zhang, Alon Agua, Wendong Huang
doaj   +1 more source

Class B scavenger receptors SR-BI/BII and CD36 mediate bacterial recognition and pro-inflammatory signaling induced by E. coli, lipopolysaccharide and cytosolic chaperonin 60

Journal of Immunology, 2011
Class B scavenger receptors (SR-B) are lipoprotein receptors that also mediate pathogen recognition, phagocytosis, and clearance as well as pathogen-induced signaling.
I. Baranova, T. Vishnyakova, A. Bocharov, Asada Leelahavanichkul, R. Kurlander, Zhi-Gang Chen, A. C. P. Souza, Peter S. T. Yuen, R. Star, G. Csako, A. P. Patterson, T. Eggerman   +11 more
semanticscholar   +1 more source

Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System

Frontiers in Immunology, 2020
The absence of MHC class II antigen presentation and multiple pathogen recognition receptors in the Atlantic cod has not impaired its immune response however how underlying mechanisms have adapted remains largely unknown.
Xingkun Jin, Xingkun Jin, Xingkun Jin, Bernat Morro, Ole K. Tørresen, Visila Moiche, Monica H. Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Simon MacKenzie   +9 more
doaj   +1 more source

Comparison of Class B Scavenger Receptors, CD36 and Scavenger Receptor BI (SR-BI), Shows That Both Receptors Mediate High Density Lipoprotein-Cholesteryl Ester Selective Uptake but SR-BI Exhibits a Unique Enhancement of Cholesteryl Ester Uptake*

Journal of Biological Chemistry, 1999
Scavenger receptor BI (SR-BI) mediates the selective uptake of high density lipoprotein (HDL) cholesteryl ester (CE), a process by which HDL CE is taken into the cell without internalization and degradation of the HDL particle.
M. Connelly, Seth M. Klein, S. Azhar, N. Abumrad, David L. Williams   +4 more
semanticscholar   +1 more source

Dimerization of the scavenger receptor class B type I [PDF]

Journal of Lipid Research, 2004
This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as tissues of transgenic animals and genetically altered steroidogenic and nonsteroidogenic cells ...
Eve Reaven, Yuan Cortez, Susan Leers-Sucheta, Ann Nomoto, Salman Azhar   +4 more
openaire   +2 more sources

Overflow phenomenon in serum lutein after supplementation: a systematic review supported with SNPs analyses [PDF]

International Journal of Ophthalmology, 2021
Lutein, a type of carotenoids, is found to delay the onset and progression of age-related macular degeneration (AMD). Several lutein supplementation studies showed that after an initial increase, lutein serum levels demonstrated a subsequent decrease ...
Abdulrahman M Alharbi, Mohammed A Kilani, Tos TJM Berendschot   +2 more
doaj   +1 more source

Pleiotropic Roles of Scavenger Receptors in Circadian Retinal Phagocytosis: A New Function for Lysosomal SR-B2/LIMP-2 at the RPE Cell Surface

International Journal of Molecular Sciences, 2022
The retinal phagocytic machinery resembles the one used by macrophages to clear apoptotic cells. However, in the retina, the permanent contact between photoreceptor outer segments (POS) and retinal pigment epithelial (RPE) cells requires a tight control ...
Quentin Rieu, A. Bougoüin, Yvrick Zagar, J. Chatagnon, Abdallah Hamieh, J. Enderlin, T. Huby, E. Nandrot   +7 more
semanticscholar   +1 more source

MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

PLoS Pathogens, 2009
Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be induced by its predominant cell wall glycolipid, trehalose 6,6 ...
Dawn M E Bowdish, Kaori Sakamoto, Mi-Jeong Kim, Mariliis Kroos, Subhankar Mukhopadhyay, Cynthia A Leifer, Karl Tryggvason, Siamon Gordon, David G Russell   +8 more
doaj   +1 more source

Contribution of Glycation and Oxidative Stress to Thyroid Gland Pathology—A Pilot Study

Biomolecules, 2021
The patho-mechanism of changes in the thyroid gland, including carcinogenesis, is a complex process, which involves oxidative stress. The goal of our investigation was to verify the extent of stress in the thyroid gland related to glycation.
Aleksandra Kuzan, Emilia Królewicz, Karolina Nowakowska, Kamilla Stach, Krzysztof Kaliszewski, Paweł Domosławski, Łukasz Kotyra, Andrzej Gamian, Irena Kustrzeba-Wójcicka   +8 more
doaj   +1 more source

Advanced glycation end products and their receptors in serum of patients with type 2 diabetes

Scientific Reports, 2021
Glycation is a non-enzymatic process involving the reaction of reducing sugars or reactive oxoaldehyde with proteins, lipids or nucleic acids, which results in the formation of advanced glycation end products (AGEs).
Diana Indyk, Agnieszka Bronowicka-Szydełko, Andrzej Gamian, Aleksandra Kuzan   +3 more
doaj   +1 more source