Results 51 to 60 of about 15,256,107 (329)

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

SR-BI-directed HDL-cholesteryl ester hydrolysis

Journal of Lipid Research, 2003
We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly, Ginny Kellner-Weibel, George H. Rothblat, David L. Williams   +3 more
doaj   +1 more source

CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products [PDF]

Journal of Biological Chemistry, 2001
Abstract: Interaction of advanced glycation end products (AGE) with AGE‐receptors induces several cellular phenomena relating potentially to diabetic complications. Five AGE‐receptors identified so far are RAGE (receptor for AGE), 80 K‐H, OST‐48, galectin‐3, and SR‐A (macrophage scavenger receptor type I and II).
N, Ohgami, R, Nagai, M, Ikemoto, H, Arai, A, Kuniyasu, S, Horiuchi, H, Nakayama   +6 more
openaire   +4 more sources

Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1)

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— The atheroprotective effects of estrogen are independent of circulating lipid levels. Whether estrogen regulates transcytosis of LDL (low-density lipoprotein) across the coronary endothelium is unknown.
S. Ghaffari, Farnoosh Naderi Nabi, Michael G. Sugiyama, Warren L. Lee   +3 more
semanticscholar   +1 more source

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

, 2010
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M, Mahabaleshwar, Harsha, Ulrike Naumann, Raz Erez, Rot, Antal, Rot Antal, Marcus Thelen, Naumann, U, Zerwes Hans-Günter, Harsha Mahabaleshwar, Naumann Ulrike, Cameroni, E, Mahabaleshwar, H, Elisabetta Cameroni, Zerwes, Hans-Günter, Raz, E, Pruenster Monika, Mahabaleshwar Harsha, Monika Pruenster, Hans-Günter Zerwes, Pruenster, Monika, Thelen, M, Thelen Marcus, Naumann, Ulrike, Cameroni, Elisabetta, Cameroni Elisabetta, Raz, Erez, Zerwes, HG, Antal Rot, Erez Raz, Thelen, Marcus   +30 more
core   +1 more source

Alzheimer’s Disease, Brain Injury, and C.N.S. Nanotherapy in Humans: Sonoporation Augmenting Drug Targeting

Medical Sciences, 2017
Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness.
Joseph S. D’Arrigo
doaj   +1 more source

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]

, 2010
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
core   +1 more source

CD36 does not play a direct role in HDL or LDL metabolism

Journal of Lipid Research, 2001
CD36 and scavenger receptor class B, type I (SR-BI) are both class B scavenger receptors that recognize a broad variety of ligands, including oxidized low density lipoprotein (oxLDL), HDL, anionic phospholipids, and apoptotic cells.
Willem J.S. de Villiers, Lei Cai, Nancy R. Webb, Maria C. de Beer, Deneys R. van der Westhuyzen, Frederick C. de Beer   +5 more
doaj   +1 more source

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus. [PDF]

PLoS Pathogens, 2016
Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of both SR-
Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura   +14 more
doaj   +1 more source

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

Nutrition & Metabolism, 2019
Background Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood.
Zhe Meng, Mengyu Wang, Junhui Xing, Yuzhou Liu, Haiyu Li   +4 more
doaj   +1 more source