Results 51 to 60 of about 51,493 (310)

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]

, 2017
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C., Buscarinu, Maria Chiara, Calo', Giorgia, Eleuteri, Cecilia, Ferrari, F., Mechelli, Rosella, Olla, S., Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Umeton, Renato, Veroni, Chiara   +11 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins

Journal of Neuroinflammation, 2004
Background Recent studies suggest that hypercholesterolemia, an established risk factor for atherosclerosis, is also a risk factor for Alzheimer's disease.
Khan Tayeba, Medeiros Lea A, Tseng Anita A, Kunjathoor Vidya V, Moore Kathryn J   +4 more
doaj   +1 more source

Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. [PDF]

, 2006
Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors.
Boullier, Agnès, Lindenbach, Brett D, McKeating, Jane A, Paulson, Matthew, Quehenberger, Oswald, Rice, Charles M, von Hahn, Thomas   +6 more
core   +1 more source

Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]

Circulation Research, 2013
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Sonika, Saddar, Véronique, Carriere, Wan-Ru, Lee, Keiji, Tanigaki, Ivan S, Yuhanna, Sajesh, Parathath, Etienne, Morel, Manya, Warrier, Janet K, Sawyer, Robert D, Gerard, Ryan E, Temel, J Mark, Brown, Margery, Connelly, Chieko, Mineo, Philip W, Shaul   +14 more
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Identification of a Candidate CD5 Homologue in the Amphibian Xenopus laevis [PDF]

, 1995
We identified a novel T cell Ag in the South African clawed toad (Xenopus laevis) by a mAb designated 2B1. This Ag is present in relatively high levels on most thymocytes, approximately 65% of splenocytes, 55% of PBL, and 65% of intestinal lymphocytes ...
Cooper, Max D., Gartland, Lanier A., Göbel, Thomas W. F., Horton, John D., Jürgens, Jutta B., Pasquier, Louis D.   +5 more
core  

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation [PDF]

, 2014
Polymersomes have the potential to encapsulate and deliver chemotherapeutic drugs into tumor cells, reducing off-target toxicity that often compromises anticancer treatment.
Acton S. L., Ahmed F., Allen-Hoffmann B. L., Araki T., Barenholz Y., Blanazs A., Canton I., Chen W., Christian D. A., Colley H. E., Craig Murdoch, Crosasso P., Denis Cecchin, Discher D. E., Duncan R., Eckert A. W., Giuseppe Battaglia, Haisma H. J., Hastie C., Hearnden V., Helen E. Colley, Hirschhaeuser F., Hu C. M., Husemann J., Irene Canton, Jane A. McKeating, Jeppe Madsen, Kamphuis M. M., Ke Hu, Koudelka S., Lee J. S., Li S., Lomas H., Lomas H., LoPresti C., Martin H. Thornhill, Massignani M., Massignani M., Massignani M., Matsumura Y., Mehta G., Milagros Avila-Olias, Moghimi S. M., Mooberry L. K., Mross K., Murdoch C., Nicholas Warren, O’Neil C. P., Patel P. C., Pegoraro C., Price K. A., Saha K., Sankar V., Schroeder A., Sheila MacNeil, Silverstein R. L., Singla A. K., Smith L. E., Steven P. Armes, Valacchi G., Vanessa Hearnden, Volkova M., von Gruenigen V., Wang L., Webb N. R., Weiszhar Z.   +65 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cellular receptors for human enterovirus species A

Frontiers in Microbiology, 2012
Human enterovirus species A (HEV-A) is one of the four species of HEV in the genus Enterovirus in the family Picornaviridae. Among HEV-A, coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are the major causative agents of hand, foot, and mouth disease
Yorihiro eNishimura, Hiroyuki eShimizu
doaj   +1 more source