Results 61 to 70 of about 51,493 (310)
Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia
American Journal of Alzheimer's Disease and Other Dementias, 2020 By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or “SR-BI”) and thereby crosses the blood ...
Joseph S. D’Arrigo PhD
doaj +1 more source
Scavenger receptors and β-glucan receptors participate in the recognition of yeasts by murine macrophages [PDF]
, 2011 Objectives: Numerous receptors have been implicated in recognition of pathogenic fungi by macrophages, including the \(\beta\)-glucan receptor dectin-1. The role of scavenger receptors (SRs) in anti-fungal immunity is not well characterized.
Janusz Marcinkiewicz +3 more
core +3 more sources
Developmental and Hormonal Regulation of Murine Scavenger Receptor, Class B, Type 1 [PDF]
Molecular Endocrinology, 1999 The scavenger receptor, class B, type I (SR-BI), is the predominant receptor that supplies plasma cholesterol to steroidogenic tissues in rodents. We showed previously that steroidogenic factor-1 (SF-1) binds a sequence in the human SR-BI promoter whose integrity is required for high-level SR-BI expression in cultured adrenocortical tumor cells. We now
G, Cao +6 more
openaire +2 more sources
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses. [PDF]
, 2020 Impaired synaptic integrity and function due to accumulation of amyloid β-protein (Aβ42) oligomers is thought to be a major contributor to cognitive decline in Alzheimer's disease (AD). However, the exact role of Aβ42 oligomers in synaptotoxicity and the
Black, Keith L +12 more
core
The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis [PDF]
, 2011 The scavenger receptor cysteine-rich (SRCR) superfamily of soluble or membrane-bound protein receptors is characterized by the presence of one or several repeats of an ancient and highly conserved protein module, the SRCR domain.
Holmskov, Uffe +4 more
core +1 more source
Scavenger receptor class B type I localizes to a late endosomal compartment [PDF]
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues. SR-BI is present on the plasma membrane but also localizes to stable intracellular compartments of unknown function.
Malika Ahras, Thet Naing, Ruth McPherson
openaire +3 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Scavenger Receptors and Atherosclerosis
Biological Research, 2000 Scavenger receptors were discovered as cell surface proteins capable of binding and internalization of modified lipoproteins. These receptors exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands ...
ATTILIO RIGOTTI
doaj
Journal of Lipid Research, 2001 Results from several laboratories clearly indicate that expression of scavenger receptor class B type I (SR-BI) enhances the bidirectional flux of cholesterol between cells and lipoproteins.
Margarita de la Llera-Moya +7 more
doaj +1 more source