Results 1 to 10 of about 12,752,015 (316)

Drug Targeting to Tumors: Principles, Pitfalls and (Pre-) Clinical Progress

Journal of Controlled Release, 2012
Twan Lammers, Wim Hennink, Fabian Kiessling   +2 more
exaly   +2 more sources

Iron oxide nanoparticles in magnetic drug targeting and ferroptosis-based cancer therapy

Medical Review, 2023
Iron oxide (IO) nanoparticles (NPs) have gained significant attention in the field of biomedicine, particularly in drug targeting and cancer therapy.
Q. T. Shubhra
semanticscholar   +1 more source

Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury

Asian Journal of Pharmaceutical Sciences, 2023
Acute liver injury (ALI) has an elevated fatality rate due to untimely and ineffective treatment. Although, schisandrin B (SchB) has been extensively used to treat diverse liver diseases, its therapeutic efficacy on ALI was limited due to its high ...
Rongping Zhang, Shiqing Luo, Ting Zhao, Mengying Wu, Lu Huang, Ling Zhang, Yuan Huang, Huile Gao, Xun Sun, Tao Gong, Zhirong Zhang   +10 more
doaj   +1 more source

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

Acta Pharmaceutica Sinica B, 2023
As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein
Fan Tong, Haili Hu, Yanyan Xu, Yang Zhou, Rou Xie, Ting Lei, Yufan Du, Wenqin Yang, Siqin He, Yuan Huang, Tao Gong, Huile Gao   +11 more
doaj   +1 more source

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Acta Pharmaceutica Sinica B, 2023
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao   +8 more
doaj   +1 more source

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

bioRxiv, 2020
The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet.
Sisi Kang, Mei Yang, Zhong-Si Hong, Li-Ping Zhang, Zhaoxia Huang, Xiao-Xue Chen, Su-Hua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Chang-Sheng Zhang, Shan Hong, Shou-Deng Chen   +13 more
semanticscholar   +1 more source

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery

Acta Pharmaceutica Sinica B, 2022
As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years.
Lei Wu, Lingling Wang, Xi Liu, Yuli Bai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, Yongxiang Zheng, Tao Gong, Zhirong Zhang, Yuan Huang   +11 more
doaj   +1 more source

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Pharmaceutics, 2020
In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented ...
Mengru Cai, Gongsen Chen, L. Qin, Chang-Hai Qu, Xiaoxv Dong, Jian Ni, Xing-Bin Yin   +6 more
semanticscholar   +1 more source

Drug Targeting via Platelet Membrane-Coated Nanoparticles

Small Structures, 2020
Platelets exhibit distinct surface moieties responsible for modulating their adhesion to various disease‐relevant substrates involving vascular damage, immune evasion, and pathogen interactions.
Shuyan Wang, Yaou Duan, Qiang-Zhe Zhang, Anvita Komarla, Hua Gong, Wei-Wei Gao, Liang-Fang Zhang   +6 more
semanticscholar   +1 more source

Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment

Pharmaceutics, 2023
Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment.
Júlia German-Cortés, Mireia Vilar-Hernández, Diana Rafael, Ibane Abasolo, Fernanda Andrade   +4 more
doaj   +1 more source