Results 1 to 10 of about 3,331,587 (315)

Preparation and evaluation of a phospholipid-based injectable gel for the long term delivery of leuprolide acetaterrh

Acta Pharmaceutica Sinica B, 2016
A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate (LA). The gel system was prepared using biocompatible materials (SPME), including soya phosphatidyl choline (SPC), medium chain triglyceride (MCT) and ...
Danhong Long, Tao Gong, Zhirong Zhang, Rui Ding, Yao Fu   +4 more
doaj   +1 more source

Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Acta Pharmaceutica Sinica B, 2019
Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (
Minglu Zhou, Lijia Li, Lian Li, Xi Lin, Fengling Wang, Qiuyi Li, Yuan Huang   +6 more
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Rh(III)-catalyzed direct cross-dehydrogenative coupling of aromatic nitriles with heteroarenes: Rapid access to biheteroaryl-2-carbonitriles

Green Synthesis and Catalysis, 2020
Transition-metal-catalyzed direct C–H/C–H cross-coupling reactions as efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.
Huibei Xu, Yanying Zhu, Xinyue Chai, Jiahui Yang, Lin Dong   +4 more
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Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity

Bioactive Materials
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation.
Yuan Xue, Shuting Bai, Yating Wang, Jiaxing Feng, Kun Xiong, Xue Tang, Chunting He, Yanhua Xu, Hongling Yu, Tianyi Luo, Qing Lin, Xun Sun, Ling Zhang, Zhirong Zhang, Tao Gong   +14 more
doaj   +1 more source

Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine

Pharmaceutical Fronts, 2020
An efficient protocol by Rh-catalyzed direct C–H vinylation of 2-arylpyridines with a commercially available and air-stable potassium vinyl donor has been developed.
Shan Lv, Ruifang Nie, Lingmei Guo, Yang Zheng, Yanzhao Liu, Li Guo, Yong Wu   +6 more
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Application of 7-azaisatins in enantioselective Morita–Baylis–Hillman reaction

Beilstein Journal of Organic Chemistry, 2016
7-Azaisatin and 7-azaoxindole skeletons are valuable building blocks in diverse biologically active substances. Here 7-azaisatins turned out to be more efficient electrophiles than the analogous isatins in the enantioselective Morita–Baylis–Hillman (MBH)
Qing He, Gu Zhan, Wei Du, Ying-Chun Chen
doaj   +1 more source

Knowledge-guided diffusion model for 3D ligand-pharmacophore mapping

Nature Communications
Pharmacophores are abstractions of essential chemical interaction patterns, holding an irreplaceable position in drug discovery. Despite the availability of many pharmacophore tools, the adoption of deep learning for pharmacophore-guided drug discovery ...
Jun-Lin Yu, Cong Zhou, Xiang-Li Ning, Jun Mou, Fan-Bo Meng, Jing-Wei Wu, Yi-Ting Chen, Biao-Dan Tang, Xiang-Gen Liu, Guo-Bo Li   +9 more
doaj   +1 more source

A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

Acta Pharmaceutica Sinica B
Chemotherapeutics can induce immunogenic cell death (ICD) in tumor cells, offering new possibilities for cancer therapy. However, the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment ...
Leilei Wang, Shanshan He, Rong Liu, Yuan Xue, Yuan Quan, Rongying Shi, Xueying Yang, Qing Lin, Xun Sun, Zhirong Zhang, Ling Zhang   +10 more
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Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins

Beilstein Journal of Organic Chemistry, 2012
The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita–Baylis–Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with ...
Hang Zhang, Shan-Jun Zhang, Qing-Qing Zhou, Lin Dong, Ying-Chun Chen   +4 more
doaj   +1 more source

Targeting the proteasome in cancer therapy: development and future opportunities in natural products

Frontiers in Pharmacology
BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma therapy and now constitutes the backbone
Xiu Zhao, Shanshan Liu, Xinrui Zeng, Yu Liao, Mao Zhang, Qiang Wang, Dan Zhang, Qifeng Chen, Miao Xian, Yong Qin   +9 more
doaj   +1 more source