Results 41 to 50 of about 12,752,015 (316)

Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment

Pharmaceutics
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design.
Fatih Çiftçi, A. Özarslan, İmran Cagri Kantarci, Aslıhan Yelkenci, Ozlem Tavukcuoglu, M. Ghorbanpour   +5 more
semanticscholar   +1 more source

Drug targeting in cancer therapy [PDF]

, 2020
Drug targeting enables the local release of medication at the desired site or organ. This ensures that the drug asserts its effects focused to a small site, minimising systematic side effects.
Ess, S., P. Raeuschl, L. Nys, R. Nestelbacher, Himly, M., M. Himly, Joubert, I.A., I.A. Joubert, Geppert, M., Nestelbacher, R., M. Geppert, Nys, L., Raeuschl, P., S. Ess, Geppert, Μ.   +14 more
core   +1 more source

Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

Research, 2023
Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD).
Qianqian Huang, Chaoqing Jiang, Xue Xia, Yufan Wang, Chenxing Yan, Xiaorong Wang, Ting Lei, Xiaotong Yang, Wenqin Yang, Guo Cheng, Huile Gao   +10 more
doaj   +1 more source

Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME.
Shu-Jing Wang, Jing-Rui Wang, Zhi-Qiang Chen, Jiamin Luo, Wei Guo, Ling-Ling Sun, Li-Zhu Lin   +6 more
semanticscholar   +1 more source

Emerging Nanotherapeutic Approaches to Overcome Drug Resistance in Cancers with Update on Clinical Trials

, 2022
A key issue with modern cancer treatments is the emergence of resistance to conventional chemotherapy and molecularly targeted medicines. Cancer nanotherapeutics were created in order to overcome the inherent limitations of traditional chemotherapeutics.
Syed Nasir Abbas Bukhari
core   +1 more source

Drug targeting to myofibroblasts: Implications for fibrosis and cancer

Advanced Drug Delivery Reviews, 2017
Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of myofibroblasts in tumor progression, invasion and metastasis has ...
S. Yazdani, Ruchi Bansal, J. Prakash
semanticscholar   +1 more source

Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2022
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to ...
Zhi-Wen Fu, Shi-Jun Li, Sifei Han, Chen Shi, Yu Zhang   +4 more
semanticscholar   +1 more source

Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells [PDF]

, 2018
Melanin binding affects drug distribution and retention in pigmented ocular tissues, thereby affecting drug response, duration of activity and toxicity.
Anna-Kaisa Rimpelä, Arto Urtti, Hagström, Marja, Rimpelä, Anna-Kaisa, Kidron, Heidi, Urtti, Arto, Heidi Kidron, Marja Hagström   +7 more
core   +1 more source

Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors

Scientific Reports, 2018
Most applications of nanotechnology in cancer have focused on systemic delivery of cytotoxic drugs. Systemic delivery relies on accumulation of nanoparticles in a target tissue through enhanced permeability of leaky vasculature and retention effect of ...
Pouyan Kheirkhah, S. Denyer, Abhiraj D. Bhimani, G. Arnone, D. Esfahani, Tania M. Aguilar, Jack Zakrzewski, Indu Venugopal, Nazia Habib, G. Gallia, A. Linninger, F. Charbel, Ankit I. Mehta   +12 more
semanticscholar   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source