Results 21 to 30 of about 3,331,587 (315)

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Exploration, 2023
In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov, Huile Gao   +6 more
doaj   +1 more source

Renal targeting of kinase inhibitors [PDF]

, 2008
Activation of proximal tubular cells by fibrotic and inflammatory mediators is an important hallmark of chronic kidney disease. We have developed a novel strategy to intervene in renal fibrosis, by means of locally delivered kinase inhibitors.
Hennink, W. E., Segers, G.J.W., Fretz, M.M., Storm, G., Hennink, W.E., Advanced drug delivery systems/drug targeting, Dolman, M. E. M., Dep Farmaceutische wetenschappen, Dolman, M.E.M., Fretz, M. M., Kok, R. J., Lacombe, M., Kok, R.J., Prakash, J., Segers, Gj. W.   +14 more
core   +1 more source

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke, Han Guo, Xi Zhu, Yun Jin, Yuan Huang   +4 more
doaj   +1 more source

Multimodal imaging of breast cancer metastasis targeting and antimetastatic nanotherapy [PDF]

, 2016
INTRODUCTION: As opposed to the routine use of nanomedicines for drug targeting to solid tumors, the highest medical need refers to targeting and treating metastasis.
Rijcken, Cristianne, Kiessling, Fabian, Pola, Robert, Chemical Biology and Drug Discovery, Lammers, Twan, Ehling, Josef, Sub Drug targeting, Sub General Pharmaceutics, Storm, G, Von Stillfried, Saskia, Rizzo, Larissa   +10 more
core   +2 more sources

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source

Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery

, 2022
In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities.
Shrestha, Archana, Lahooti, Behnaz, Mikelis, Constantinos M., Constantinos M. Mikelis, Behnaz Lahooti, Mattheolabakis, George, Archana Shrestha, George Mattheolabakis   +7 more
core   +1 more source

Drug targets in Leishmania [PDF]

Journal of Parasitic Diseases, 2010
Leishmaniasis is a major public health problem and till date there are no effective vaccines available. The control strategy relies solely on chemotherapy of the infected people. However, the present repertoire of drugs is limited and increasing resistance towards them has posed a major concern.
Bhavna, Chawla, Rentala, Madhubala
openaire   +2 more sources

Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis

Asian Journal of Pharmaceutical Sciences, 2019
To achieve targeted thrombolysis, a targeted delivery system of lumbrokinase (LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GPⅡb/Ⅲa expressed on the surface of membrane of ...
Yang Pan, Xiahui Wang, Zongning Yin
doaj   +1 more source

Recent Progress in Gas Sensors Based on P3HT Polymer Field-Effect Transistors

Sensors, 2023
In recent decades, the rapid development of the global economy has led to a substantial increase in energy consumption, subsequently resulting in the emission of a significant quantity of toxic gases into the environment.
Si Cheng, Yifan Wang, Ruishi Zhang, Hongjiao Wang, Chenfang Sun, Tie Wang   +5 more
doaj   +1 more source

Complement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugs [PDF]

, 2015
Liposomes are known to activate the complement (C) system, which can lead in vivo to a hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has been getting increasing attention as a safety risk of i.v.
Pharmaceutics, Sub Drug targeting, Storm, G, Szebeni, Janos   +3 more
core   +2 more sources