Results 21 to 30 of about 12,752,015 (316)

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Exploration, 2023
In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov, Huile Gao   +6 more
doaj   +1 more source

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Science, 2020
Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wen-Hao Dai, Bing Zhang, Xia-Ming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhen-Ming Jin, Jing-Jing Peng, Feng-Jiang Liu, Chun-Pu Li, You Li, Fang Bai, Hao-Feng Wang, Xi Cheng, Xiaobo Cen, Shu-Lei Hu, Xiu-Na Yang, Jiang Wang, Xiang Liu, Geng-Fu Xiao, Hua-Liang Jiang, Z. Rao, Lei-Ke Zhang, Yechun Xu, Hai-Tao Yang, Hong Liu   +26 more
semanticscholar   +1 more source

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke, Han Guo, Xi Zhu, Yun Jin, Yuan Huang   +4 more
doaj   +1 more source

Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication

, 2021
Dual-targeting therapeutics by coadministration of allosteric and orthosteric drugs is drawing increased attention as a revolutionary strategy for overcoming the drug-resistance problems.
Shaoyong Lu, Xinyi Li, Yuanhao Wang, Xiaolan Yin, Qiang Fu, Renhua Huang, Yuran Qiu   +6 more
core   +1 more source

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source

Therapeutic advances in cardiac targeted drug delivery: from theory to practice

, 2021
The most commonly used administration methods in clinics and life are oral administration, intravenous injection, and other systemic administration methods.
Dar, Kashif, Saeed, Muhammad, Dingding, Chen, Baig, Mirza Muhammad Faran Ashraf, Feng, Yu, Naveed, Muhammad, Li, Cuican, Lv, Rundong, Liu, Ziwei, Xiaohui, Zhou   +9 more
core   +1 more source

Recent expansions of novel strategies towards the drug targeting into the brain

International Journal of Nanomedicine, 2019
The treatment of central nervous system (CNS) disorders always remains a challenge for the researchers. The presence of various physiological barriers, primarily the blood–brain barrier (BBB) limits the accessibility of the brain and hinders the efficacy
A. Alexander, Mukta Agrawal, A. Uddin, S. Siddique, A. Shehata, Mahmoud A. Shaker, Syed Ata Ur Rahman, Mohi Iqbal M. Abdul, M. Shaker   +8 more
semanticscholar   +1 more source

Passive targeting of drug.

Drug Delivery System, 1999
This review briefly explains concept, methodology, and historical background of passive targeting of drug. Historically, it was believed that active targeting using monoclonal antibodies was a more selective and efficient targeting methodology than passive targeting.
Takakura, Yoshinobu, Maruyama, Kazuo, Yokoyama, Masayuki   +2 more
openaire   +2 more sources

Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

, 2022
Drug targeting and nanomedicine are different strategies for improving the delivery of drugs to their target. Several antibodies, immuno-drug conjugates and nanomedicines are already approved and used in clinics, demonstrating the potential of such ...
Klaas Poelstra, Anna Salvati
core   +1 more source

Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches

, 2022
Mitochondria are implicated in a wide range of functions apart from ATP generation, and, therefore, constitute one of the most important organelles of cell.
Asimul Islam, Bhardwaj, Priyanka, Zainy Zehra, Jaoud Ansari, Islam, Asimul, Waseem, Rashid, Tanzeel Khan, Ansari, Jaoud, Hassan, Md. Imtaiyaz, Rashid Waseem, Khan, Tanzeel, Zehra, Zainy, Ayesha Aiman, Aiman, Ayesha, Md. Imtaiyaz Hassan, Priyanka Bhardwaj   +15 more
core   +1 more source