Results 11 to 20 of about 3,331,587 (315)
Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury
Asian Journal of Pharmaceutical Sciences, 2023 Acute liver injury (ALI) has an elevated fatality rate due to untimely and ineffective treatment. Although, schisandrin B (SchB) has been extensively used to treat diverse liver diseases, its therapeutic efficacy on ALI was limited due to its high ...
Rongping Zhang +10 more
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Acta Pharmaceutica Sinica B, 2023 As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein
Fan Tong +11 more
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Acta Pharmaceutica Sinica B, 2023 Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu +8 more
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Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
Acta Pharmaceutica Sinica B, 2022 As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years.
Lei Wu +11 more
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Drugs and Targets in Fibrosis [PDF]
Frontiers in Pharmacology, 2017 Fibrosis contributes to the development of many diseases and many target molecules are involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to specific diseases or organs. However, accumulating evidence demonstrates great similarities among fibroproliferative diseases, and more and more drugs are proved to be ...
Xiaoyi Li +5 more
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Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment
Pharmaceutics, 2023 Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment.
Júlia German-Cortés +4 more
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BMC Genomics, 2014 Genome wide association studies (GWAS) have revealed a large number of links between genome variation and complex disease. Among other benefits, it is expected that these insights will lead to new therapeutic strategies, particularly the identification of new drug targets.
Cao, Chen, Moult, John
openaire +3 more sources
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Acta Pharmaceutica Sinica B, 2020 Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo +6 more
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Molecular Therapy: Methods & Clinical Development, 2023 Following the recent approval of both siRNA- and mRNA-based therapeutics, nucleic acid therapies are considered a game changer in medicine. Their envisioned widespread use for many therapeutic applications with an array of cellular target sites means ...
Rasmus Münter +3 more
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Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland
Scientific Reports, 2017 Transporters involved in bile acid (BA) handling by the mammary gland are poorly understood. Here we have investigated the role of ABC proteins in blood-milk BA traffic and its sensitivity to maternal cholestasis. BA concentrations in rat and mouse serum
Alba M. G. Blazquez +5 more
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