Results 11 to 20 of about 12,752,015 (316)
Quantitative estimate of protein-protein interaction targeting drug-likeness [PDF]
, 2021 The quantification of drug-likeness is very useful for screening drug candidates. The quantitative estimate of drug-likeness (QED) is the most commonly used quantitative drug efficacy assessment method proposed by Bickerton et al.
Takatsugu, Kosugi, Masahito, Ohue
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European Journal of Pharmaceutical Sciences, 2000 The main problems currently associated with systemic drug administration are: even biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a pathological site; the necessity of a large total dose of a drug to achieve high local concentration; non-specific toxicity and other adverse side-effects due to high drug
FREEMAN SALLY +2 more
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Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
, 2022 In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities.
Shrestha, Archana +7 more
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Membrane Trafficking and Subcellular Drug Targeting Pathways
Frontiers in Pharmacology, 2020 The movement of micro and macro molecules into and within a cell significantly governs several of their pharmacokinetic and pharmacodynamic parameters, thus regulating the cellular response to exogenous and endogenous stimuli.
Ajay Kumar +3 more
semanticscholar +1 more source
"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]
, 2005 The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
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Mitochondria-Targeted Drugs [PDF]
Current Molecular Pharmacology, 2019 Background:Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs.
Zinovkin, Roman A., Zamyatnin, Andrey A.
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Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Acta Pharmaceutica Sinica B, 2020 Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo +6 more
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Molecular Therapy: Methods & Clinical Development, 2023 Following the recent approval of both siRNA- and mRNA-based therapeutics, nucleic acid therapies are considered a game changer in medicine. Their envisioned widespread use for many therapeutic applications with an array of cellular target sites means ...
Rasmus Münter +3 more
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Chemical approaches to targeting drug resistance cancer stem cells [PDF]
, 2016 STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Micallef, Neville +6 more
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Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland
Scientific Reports, 2017 Transporters involved in bile acid (BA) handling by the mammary gland are poorly understood. Here we have investigated the role of ABC proteins in blood-milk BA traffic and its sensitivity to maternal cholestasis. BA concentrations in rat and mouse serum
Alba M. G. Blazquez +5 more
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