Results 61 to 70 of about 3,331,587 (315)

Targeting the Opening of Mitochondrial Permeability Transition Pores Potentiates Nanoparticle Drug Delivery and Mitigates Cancer Metastasis

Advanced Science, 2021
Mitochondria are highly involved in the metastasis of cancer cells. However, low permeability of mitochondria impedes the entry of anti‐cancer drugs. Here, a self‐assembled nanoparticle platform is designed that not only targets the DNA‐intercalating ...
Xi Lin, Lian Li, Shujie Li, Qiuyi Li, Dandan Xie, Minglu Zhou, Yuan Huang   +6 more
doaj   +1 more source

RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature [PDF]

, 2005
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to αvβ3- integrin expressing tumour vasculature.
Schiffelers, Raymond M., Pharmaceutics, Kok, Robbert J., Sub Drug delivery, Molema, Grietje, Temming, Kai, Sub Drug targeting   +6 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation

Nano Research
Being a Th2 stimulator, classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous cells.
Chunting He, Penghui He, Xue Tang, Shuting Bai, Ming Qin, Yunting Zhang, Zhaofei Guo, Guangsheng Du, Xun Sun   +8 more
doaj   +1 more source

Validated LC-MS/MS Method for the Determination of Scopoletin in Rat Plasma and Its Application to Pharmacokinetic Studies

Molecules, 2015
A rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometric method was developed and validated for the quantification of scopoletin in rat plasma.
Yingchun Zeng, Sha Li, Xiaohong Wang, Tao Gong, Xun Sun, Zhirong Zhang   +5 more
doaj   +1 more source

Design of kidney-targeted drug-carrier conjugates for the inhibition of profibrotic signaling cascades [PDF]

, 2011
In the past decades, the worldwide number of patients with chronic kidney disease (CKD) has increased remarkably and it is expected that this increasing trend will continue during the coming years (1). At this moment, therapy is focused on the prevention
Pharmaceutics, Dolman, M.E.M., Sub Drug targeting   +2 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers [PDF]

, 2009
Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics.
Ulbrich, K., Huber, P.E., Dep Farmaceutische wetenschappen, Peschke, P., Lammers, T., Hennink, W.E., Storm, G., Advanced drug delivery systems/drug targeting, Subr, V.   +8 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Self-assembled materials from thermosensitive and biohybrid block copolymers [PDF]

, 2012
In this research, several block copolymers were synthesized and characterized with regard to possible pharmaceutical applications. All block copolymers were thermosensitive and self-assembled at 37 °C into structures like micelles and hydrogels, which ...
Pharmaceutics, Dep Farmaceutische wetenschappen, Sub Drug targeting, de Graaf, A.J., Advanced drug delivery systems/drug targeting   +4 more
core   +1 more source