Results 81 to 90 of about 3,331,587 (315)

Chemical approaches to targeting drug resistance cancer stem cells [PDF]

, 2016
STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Micallef, Neville, Cassar, Analisse, Stipourou, Iona, Blaire Theuma, Krystle, Suleiman, Sherif, Schembri-Wismayer, Pierre, Passarella, Daniele   +6 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Targeted inhibition of cancer-inflammation [PDF]

, 2012
The new paradigm in cancer treatment that aims to inhibit the smoldering inflammatory response in tumors is explored to develop new anticancer treatments.
Pharmaceutics, Sub Drug targeting, Gomes Coimbra, M.J.   +2 more
core  

Targeting the Choroid Plexuses for Protein Drug Delivery

, 2020
Delivery of therapeutic agents to the central nervous system is challenged by the barriers in place to regulate brain homeostasis. This is especially true for protein therapeutics. Targeting the barrier formed by the choroid plexuses at the interfaces of
Anthony M. Snyder, Abbas R. Rizvi, Mark A. Bryniarski, Marilyn E. Morris, Tianjing Ren   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Scientific Value of Non-Clinical Animal Studies in Drug Development [PDF]

, 2013
Animal studies are considered needed as predictive models to evaluate safety and efficacy of new pharmaceuticals and are required by law. However, the scientific basis of the current paradigm on the predictability of animal studies for the effects of ...
Pharmaceutics, van Meer, P.J.K., Sub Drug targeting   +2 more
core  

The therapeutic equivalence of complex drugs [PDF]

, 2011
When the patent of a small molecule drug expires generics may be introduced. They are considered therapeutically equivalent once pharmaceutical equivalence (i.e. identical active substances) and bioequivalence (i.e. comparable pharmacokinetics) have been
Pharmaceutics, Sub Drug delivery, Jean-Francois Brin, Schellekens, Huub, Klinger, Ety, Muehlebach, S., Daan J.A. Crommelin, Sub Drug targeting, Storm, G., Advanced drug delivery systems/drug targeting, Crommelin, Daan J. A., Klinger, E., Schellekens, H., Gert Storm, Dep Farmaceutische wetenschappen, Crommelin, D.J.A., Brin, Jean-Francois, Huub Schellekens, Stefan Mühlebach, Mühlebach, Stefan, Ety Klinger, Innovation Studies, Storm, Gert, Brin, J-F.   +23 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology [PDF]

, 2006
Endothelial cells play an important role in inflammatory disorders, as they control the recruitment of leukocytes into inflamed tissue and the formation of new blood vessels.
van der Hoeven, Paul, Keri, Gyorgy, Poelstra, Klaas, Kok, Robbert J., Molema, G., Advanced drug delivery systems/drug targeting, Orfi, Laszlo, Dep Farmaceutische wetenschappen, Poelstra, Klaas; id_orcid, van der Hoeven, P., Keri, G., Dijkers, Eli C. F., Temming, K., Molema, Grietje; id_orcid, Sub Drug targeting, Gonzalo, T., Prakash, Jai, Orfi, L., Gonzalo, Teresa, Lacombe, Marie, Molema, Grietje, Temming, Kai, Lacombe, M., Kok, R.J., Pradash, J., Dijkers, E.C.F., Poelstra, K.   +26 more
core   +3 more sources