Functional characterization of newly-discovered mutations in human SR-BI. [PDF]
PLoS ONE, 2012 In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined.
Alexandra C Chadwick, Daisy Sahoo
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Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI [PDF]
Journal of Biological Chemistry, 2006 Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear.
Bietrix, Florence +11 more
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Different Functions of Human Scavenger Receptors BI and BII Overexpressed in a Murine Abdominal Sepsis Model [PDF]
BiomoleculesClass B scavenger receptor BI splice variants (SR-BI) and BII (SR-BII) internalize lipoproteins but also bind and internalize bacteria. Their individual roles in sepsis are unknown. We overexpressed human SR-BI or BII in transgenic mice, primarily in the
Naoki Hayase +8 more
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Identification of scavenger receptor BI as a scavenger of free heme that is essential for protection against hemolysis [PDF]
Nature CommunicationsSevere hemolysis is a life-threatening condition with limited therapeutic options. Although haptoglobin and hemopexin sequester hemoglobin and heme, these protective systems are rapidly saturated during acute hemolysis, leading to the accumulation of ...
Misa Ito +18 more
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Effects of SR-BI rs5888 and rs4238001 variations on hypertension
Turkish Journal of Biochemistry, 2019 Abstract Background Scavenger receptor class B, type I (SR-BI), involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL and VLDL. SR-BI may contribute to the development of hypertension due to accumulation of cholesterol in the vessel wall via ...
Burcu Çaykara +6 more
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Role of SR-BI in atherosclerosis, malignancies, and infectious diseases
Infection International, 2018 Abstract Scavenger receptor class B type I (SR-BI) is a high-affinity receptor for high-density lipoprotein (HDL). The primary role of this receptor is the selective uptake of HDLs in the liver through reverse cholesterol transport. SR-BI interacts with HDL to regulate lipid metabolism and affects various vascular cell functions involved in ...
Zhe An
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SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. [PDF]
PLoS ONE, 2013 SR-BI deficient mice that are also hypomorphic for apolipoprotein E expression develop diet induced occlusive coronary artery atherosclerosis, myocardial infarction and early death.
Ying Pei +8 more
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Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. [PDF]
PLoS Pathogens, 2009 HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I (SR-BI),
Marlène Dreux +10 more
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SR-BI as a target of natural products and its significance in cancer [PDF]
Seminars in Cancer Biology, 2022 Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi ...
Wang, Dongdong +10 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium.
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