Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. [PDF]
PLoS ONE, 2013 PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins.
Kosuke Tsukamoto +5 more
doaj +15 more sources
SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1. [PDF]
Front Physiol, 2017 The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier.
Fung KY +5 more
europepmc +2 more sources
SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. [PDF]
Atherosclerosis, 2017 High-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein species due to its role in reverse cholesterol transport. HDL delivers cholesterol esters to the liver through selective uptake by scavenger receptor class B type I (SR-BI).
M. Hoekstra
semanticscholar +3 more sources
Alternative forms of the scavenger receptor BI (SR-BI)
Journal of Lipid Research, 1997 The class B, type I scavenger receptor has been implicated as a receptor for high density lipoprotein (HDL). We have isolated a murine cDNA clone encoding an alternative form of SR-BI that differs in the putative cytoplasmic domain of the receptor.
N R Webb +4 more
doaj +3 more sources
SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. [PDF]
PLoS ONE, 2013 SR-BI deficient mice that are also hypomorphic for apolipoprotein E expression develop diet induced occlusive coronary artery atherosclerosis, myocardial infarction and early death.
Ying Pei +8 more
doaj +2 more sources
Baicalin promotes cholesterol efflux by regulating the expression of SR-BI in macrophages. [PDF]
Exp Ther Med, 2016 Intake of a high dosage of baicalin has previously been shown to attenuate hyperlipidemia induced by a high-fat diet. Baicalin functions as an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ), which is the key regulator of reverse ...
Yu R +9 more
europepmc +2 more sources
SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer. [PDF]
Front Pharmacol, 2016 Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the progression of cancer. The SCARB1 gene encodes the scavenger receptor class B type I (SR-BI), which is an 82-kDa glycoprotein with two transmembrane domains ...
Gutierrez-Pajares JL +3 more
europepmc +2 more sources
SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry [PDF]
Frontiers in Microbiology, 2019 Hepatitis C virus (HCV) entry is mediated by multiple co-receptors including scavenger receptor class B, type I (SR-BI). To elucidate the interactome of human SR-BI, we performed immunoprecipitation (IP) experiment coupled with mass spectrometry (MS ...
Jiazhao Huang +7 more
doaj +2 more sources
SR-BI-directed HDL-cholesteryl ester hydrolysis
Journal of Lipid Research, 2003 We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly +3 more
doaj +3 more sources
S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. [PDF]
J Lipid Res, 2017 HDL normally transports about 50–70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors for S1P (
Lee MH +8 more
europepmc +2 more sources