Results 11 to 20 of about 895,142 (270)

Functional characterization of newly-discovered mutations in human SR-BI. [PDF]

PLoS ONE, 2012
In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined.
Alexandra C Chadwick, Daisy Sahoo
doaj   +5 more sources

Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI [PDF]

Journal of Biological Chemistry, 2006
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear.
Bietrix, Florence, Yan, Daoguang, Nauze, Michel, Rolland, Corinne, Bertrand-Michel, Justine, Coméra, Christine, Schaak, Stephane, Barbaras, Ronald, Groen, Albert K., Perret, Bertrand, Tercé, François, Collet, Xavier   +11 more
openaire   +3 more sources

SR-BI-directed HDL-cholesteryl ester hydrolysis

Journal of Lipid Research, 2003
We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly, Ginny Kellner-Weibel, George H. Rothblat, David L. Williams   +3 more
doaj   +3 more sources

Effects of SR-BI rs5888 and rs4238001 variations on hypertension

Turkish Journal of Biochemistry, 2019
Abstract Background Scavenger receptor class B, type I (SR-BI), involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL and VLDL. SR-BI may contribute to the development of hypertension due to accumulation of cholesterol in the vessel wall via ...
Burcu Çaykara, Hani Alsaadoni, Halime Hanım Pençe, Sadrettin Pençe, Hülya Yılmaz Aydoğan, Sibel Şabançelebi, Ahmet Yıldız   +6 more
openaire   +2 more sources

Role of SR-BI in atherosclerosis, malignancies, and infectious diseases

Infection International, 2018
Abstract Scavenger receptor class B type I (SR-BI) is a high-affinity receptor for high-density lipoprotein (HDL). The primary role of this receptor is the selective uptake of HDLs in the liver through reverse cholesterol transport. SR-BI interacts with HDL to regulate lipid metabolism and affects various vascular cell functions involved in ...
Zhe An
openaire   +2 more sources

SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. [PDF]

PLoS ONE, 2013
SR-BI deficient mice that are also hypomorphic for apolipoprotein E expression develop diet induced occlusive coronary artery atherosclerosis, myocardial infarction and early death.
Ying Pei, Xing Chen, Dina Aboutouk, Mark T Fuller, Omid Dadoo, Pei Yu, Elizabeth J White, Suleiman A Igdoura, Bernardo L Trigatti   +8 more
doaj   +1 more source

SR-BI as a target of natural products and its significance in cancer [PDF]

Seminars in Cancer Biology, 2022
Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi ...
Wang, Dongdong, Huang, Jiansheng, Gui, Ting, Yang, Yaxin, Feng, Tingting, Tzvetkov, Nikolay T, Xu, Tao, Gai, Zhibo, Zhou, Ying, Zhang, Jingjie, Atanasov, Atanas G   +10 more
openaire   +4 more sources

Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. [PDF]

PLoS Pathogens, 2009
HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I (SR-BI),
Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, Birke Bartosch   +10 more
doaj   +1 more source

SR-BI [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium.
openaire   +2 more sources

Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert, Joerg Heeren, Mukaddes Bahar-Bayansar, Anne Ewert, Kathryn J. Moore, Franz Rinninger   +5 more
doaj   +1 more source