Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques [PDF]
BMC Cardiovascular Disorders, 2005 Background The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile.
Fagerberg Björn +11 more
doaj +4 more sources
Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]
Circulation Research, 2013 Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Véronique Carriere +2 more
exaly +5 more sources
Dimerization of the scavenger receptor class B type I [PDF]
Journal of Lipid Research, 2004 This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as
Eve Reaven +4 more
doaj +2 more sources
Sterol regulation of scavenger receptor class B type I in macrophages [PDF]
Journal of Lipid Research, 2004 Scavenger receptor class B type I (SR-BI) is expressed in macrophages, but its role in sterol trafficking in these cells remains controversial. We examined the effect of sterol loading on SR-BI expression in human monocytes/macrophages, mouse peritoneal ...
Liqing Yu +3 more
doaj +3 more sources
Remodeling of HDL remnants generated by scavenger receptor class B type I [PDF]
Journal of Lipid Research, 2004 Scavenger receptor class B type I (SR-BI) mediates the selective transfer of cholesteryl ester from HDL to cells. We previously established that SR-BI overexpressed in livers of apolipoprotein A-I-deficient mice processes exogenous human HDL2 to ...
Nancy R. Webb +5 more
doaj +3 more sources
Scavenger receptor class B type I localizes to a late endosomal compartment [PDF]
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues.
Malika Ahras, Thet Naing, Ruth McPherson
doaj +3 more sources
Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I [PDF]
EMBO reports, 2002 The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and
Schoonjans, Kristina +15 more
core +4 more sources
Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine [PDF]
Journal of Lipid Research, 2001 The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai +3 more
doaj +3 more sources
Scavenger receptor class B, type I: a promising immunotherapy target
Immunotherapy, 2011 Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux.
José Medina-Echeverz +2 more
core +3 more sources
Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism [PDF]
EMBO Molecular MedicineCardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1)
Yufei Wu +25 more
doaj +2 more sources