Results 1 to 10 of about 144,135 (296)

Is reverse cholesterol transport regulated by active cholesterol? [PDF]

Journal of Lipid Research, 2023
This review considers the hypothesis that a small portion of plasma membrane cholesterol regulates reverse cholesterol transport in coordination with overall cellular homeostasis.
Theodore L. Steck, Yvonne Lange
doaj   +4 more sources

Apoprotein E and Reverse Cholesterol Transport. [PDF]

Int J Mol Sci, 2018
Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions, apoE is involved in cholesterol efflux, especially from cholesterol-loaded macrophage foam cells and ...
Getz GS, Reardon CA.
europepmc   +6 more sources

HDL and Reverse Cholesterol Transport. [PDF]

Circ Res, 2019
Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the leading cause of death worldwide. It is well established that cholesterol ester-enriched foam cells are the hallmark of atherosclerotic plaques. Multiple lines of evidence support that enhancing foam cell cholesterol efflux by HDL (high-density lipoprotein ...
Ouimet M, Barrett TJ, Fisher EA.
europepmc   +5 more sources

Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy [PDF]

Journal of Diabetes Research, 2021
Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body.
Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Qiyun Wang   +3 more
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Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives [PDF]

Cardiovascular Therapeutics, 2022
Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu, Zikai Song, Bao Mao, Guoliang Xu   +3 more
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PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia [PDF]

JACC: Basic to Translational Science
Summary: We investigated the potential of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies to restore macrophage cholesterol efflux in subjects with heterozygous familial hypercholesterolemia (FH) and to enhance the macrophage-specific ...
Carla Borràs, MSc, Marina Canyelles, PhD, Josefa Girona, PhD, Daiana Ibarretxe, MD, PhD, David Santos, BS, Giovanna Revilla, PhD, Vicenta Llorente-Cortes, PhD, Noemí Rotllan, PhD, Petri T. Kovanen, MD, PhD, Matti Jauhiainen, PhD, Miriam Lee-Rueckert, PhD, Luis Masana, MD, PhD, Francisco Arrieta, MD, PhD, Javier Martínez-Botas, PhD, Diego Gómez-Coronado, PhD, Josep Ribalta, PhD, Mireia Tondo, PhD, Francisco Blanco-Vaca, MD, PhD, Joan Carles Escolà-Gil, PhD   +18 more
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Reverse cholesterol transport and hepatic osteodystrophy. [PDF]

Cell Metab, 2022
In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic ...
Zaidi M, Yuen T, Iqbal J.
europepmc   +3 more sources

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
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Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway [PDF]

Drug Design, Development and Therapy, 2021
Yingnan Zhao,1,2 Yanping Li,2 Qinhui Liu,1 Qin Tang,1,2 Zijing Zhang,1,2 Jinhang Zhang,1,2 Cuiyuan Huang,1,2 Hui Huang,1,2 Guorong Zhang,1,2 Jian Zhou,1,2 Jiamin Yan,1,2 Yan Xia,1,2 Zhiyong Zhang,1,2 Jinhan He1,2 1Department of Pharmacy, National ...
Zhao Y, Li Y, Liu Q, Tang Q, Zhang Z, Zhang J, Huang C, Huang H, Zhang G, Zhou J, Yan J, Xia Y, Zhang Z, He J   +13 more
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HDL and Reverse Cholesterol Transport Biomarkers. [PDF]

Methodist Debakey Cardiovasc J, 2019
High-density lipoprotein (HDL) is a protein-lipid nanoparticle that has predominately been characterized by its cholesterol concentration (HDL-C). Recent studies have challenged the presumed inverse association between HDL-C and cardiovascular events, suggesting a more U-shaped association.
Riggs KA, Rohatgi A.
europepmc   +4 more sources