Results 1 to 10 of about 73,387 (251)

Reverse Cholesterol Transport and Atherosclerosis. [PDF]

Arterioscler Thromb Vasc Biol, 2019
Rohatgi A.
europepmc   +5 more sources

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity

Journal of Lipid Research, 2009
The main antiatherogenic function of HDL is to promote the efflux of cholesterol from peripheral cells and transport it to the liver for excretion in a process termed reverse cholesterol transport.
Shuhei Nakanishi, Riikka Vikstedt, Sanni Söderlund, Miriam Lee-Rueckert, Anne Hiukka, Christian Ehnholm, Mikko Muilu, Jari Metso, Jussi Naukkarinen, Leena Palotie, Petri T. Kovanen, Matti Jauhiainen, Marja-Riitta Taskinen   +12 more
doaj   +1 more source

The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study*[S]

Journal of Lipid Research, 2009
Low HDL-cholesterol (HDL-C) is associated with an increased risk for atherosclerosis, and concentrations are modulated by genetic factors and environmental factors such as smoking.
Mireia Junyent, Katherine L. Tucker, Caren E. Smith, Antonio Garcia-Rios, Josiemer Mattei, Chao-Qiang Lai, Laurence D. Parnell, Jose M. Ordovas   +7 more
doaj   +1 more source

Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury

Research, 2023
Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered a barrier for regeneration in the central nervous system.
Bolin Zheng, Yijing He, Shuai Yin, Xu Zhu, Qing Zhao, Huiyi Yang, Zhaojie Wang, Rongrong Zhu, Liming Cheng   +8 more
doaj   +1 more source

ABCA1: the gatekeeper for eliminating excess tissue cholesterol

Journal of Lipid Research, 2001
It is widely believed that HDL functions to transport cholesterol from peripheral cells to the liver by reverse cholesterol transport, a pathway that may protect against atherosclerosis by clearing excess cholesterol from arterial cells.
John F. Oram, Richard M. Lawn
doaj   +1 more source

High density lipoprotein – a hero, a mirage or a witness?

Frontiers in Cardiovascular Medicine, 2014
Negative relationship between plasma High Density Lipoprotein (HDL) levels and risk of cardiovascular disease is a firmly established medical fact, but attempts to reproduce protective properties of HDL by pharmacologically elevating HDL levels were ...
Dmitri eSviridov
doaj   +1 more source

Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro

Biomolecules, 2022
ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to cholesterol metabolism, several studies have assessed the impact of ABCA1 and ...
Ikechukwu Esobi, Olanrewaju Oladosu, Jing Echesabal-Chen, Alexis Stamatikos   +3 more
doaj   +1 more source

P2Y13 Receptor Is Critical for Reverse Cholesterol Transport [PDF]

Hepatology, 2010
A major atheroprotective functionality of high-density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT). In this process, HDLs mediate the efflux and transport of cholesterol from peripheral cells and its subsequent transport to the liver for further metabolism and ...
Fabre, Aurélie, Malaval, Camille, Ben Addi, Abduelhakem, Verdier, Céline, Pons, Véronique, Serhan, Nizar, Lichtenstein, Laeticia, Combes, Guillaume, Huby, Thierry, Briand, François, Collet, Xavier, Nijstad, Niels, Tietge, Uwe J.F., Robaye, Bernard, Perret, Bertrand, Boeynaems, Jean-Marie, Martinez, Laurent   +16 more
openaire   +5 more sources

2nd International Symposium on Reverse Cholesterol Transport: report on a meeting.

Journal of Lipid Research, 1994
The purpose of this symposium was to provide a forum for presenting recent findings and for exchange of ideas concerning reverse cholesterol transport.
A G Lacko, P H Pritchard
doaj   +1 more source

Alcohol consumption stimulates early steps in reverse cholesterol transport

Journal of Lipid Research, 2001
Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known.
M.S. van der Gaag, A. van Tol, S.H.F. Vermunt, L.M. Scheek, G. Schaafsma, H.F.J. Hendriks   +5 more
doaj   +1 more source