Results 1 to 10 of about 24,034 (108)

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9[S]

Journal of Lipid Research, 2015
Recently, we showed in APOE*3-Leiden cholesteryl ester transfer protein (E3L.CETP) mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL cholesterol [(V)LDL-C] rather than by raising HDL cholesterol.
Sam J.L. van der Tuin, Susan Kühnast, Jimmy F.P. Berbée, Lars Verschuren, Elsbet J. Pieterman, Louis M. Havekes, José W.A. van der Hoorn, Patrick C.N. Rensen, J. Wouter Jukema, Hans M.G. Princen, Ko Willems van Dijk, Yanan Wang   +11 more
doaj   +1 more source

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

Redox Biology, 2017
Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death.
Sandra Torres, Nuria Matías, Anna Baulies, Susana Nuñez, Cristina Alarcon-Vila, Laura Martinez, Natalia Nuño, Anna Fernandez, Joan Caballeria, Thierry Levade, Alba Gonzalez-Franquesa, Pablo Garcia-Rovés, Elisa Balboa, Silvana Zanlungo, Gemma Fabrías, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C. Fernández-Checa   +18 more
doaj   +1 more source

Innovative Lipid-Lowering Strategies: RNA-Based, Small Molecule, and Protein-Based Therapies [PDF]

Endocrinology and Metabolism
Dyslipidemia remains a central modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD). While 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, as well as ezetimibe, fibrates, and omega-3 ...
Youngwoo Jang, Eun-Jung Rhee, Sung Hee Choi   +2 more
doaj   +1 more source

ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response

Journal of Lipid Research, 2001
High density lipoproteins (HDL) mediate reverse cholesterol transport as well as the clearance of oxidation products or inflammatory mediators, thereby contributing to tissue integrity. The decrease in HDL in inflammation has been attributed to decreased
Stefan Barlage, Dieter Fröhlich, Alfred Böttcher, Matti Jauhiainen, Hans Peter Müller, Felicitas Noetzel, Gregor Rothe, Christine Schütt, Reinhold P. Linke, Karl J. Lackner, Christian Ehnholm, Gerd Schmitz   +11 more
doaj   +1 more source

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

BMC Endocrine Disorders, 2005
Background Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM).
Mittal Balraj, Bhattacharya Sandeep, Dixit Manjusha   +2 more
doaj   +1 more source

Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice

Frontiers in Physiology, 2018
Aerobic exercise training (AET) improves the reverse cholesterol transport (RCT) in cholesteryl ester transfer protein-transgenic (CETP-tg) mice. We aimed at investigating the role of AET in the expression of genes and proteins involved in lipid flux in ...
Paula R. Pinto, Karolline S. da Silva, Rodrigo T. Iborra, Rodrigo T. Iborra, Ligia S. Okuda, Diego Gomes-Kjerulf, Guilherme S. Ferreira, Adriana Machado-Lima, Debora D. F. M. Rocco, Edna R. Nakandakare, Ubiratan F. Machado, Maria L. Correa-Giannella, Maria L. Correa-Giannella, Sergio Catanozi, Marisa Passarelli   +14 more
doaj   +1 more source

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.

PLoS ONE, 2019
Rabbits with naturally high levels of cholesterol ester transfer protein (CETP), unlike rodents, have become an interesting animal model for the study of lipid metabolism and atherosclerosis, as they have similarities to humans in lipid metabolism ...
Anja Beierfuß, Monika Hunjadi, Andreas Ritsch, Christian Kremser, Claudius Thomé, Demissew Shenegelegn Mern   +5 more
doaj   +1 more source

Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?

Biomolecules
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol ...
Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis   +9 more
doaj   +1 more source

Immunotherapy and vaccine-based approaches for atherosclerosis prevention: a systematic review study

BMC Cardiovascular Disorders
Introduction Cardiovascular disease is a major global health issue, and atherosclerosis is a leading cause of cardiovascular conditions. Traditional approaches for managing atherosclerosis have limitations, creating a need for alternative preventive ...
Mansoureh Shekarchizadeh Esfahani, Mansour Siavash, Raheleh Sadat Sajad, Amirhossein Ramezani Ahmadi, Mozhgan Karimifar, Mojtaba Akbari, Masood Shekarchizadeh   +6 more
doaj   +1 more source

Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo. [PDF]

Acta Physiol (Oxf)
Henderson GC, Buhman KK, Tomoo K.
europepmc   +1 more source