Results 11 to 20 of about 53,010 (291)

Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport [PDF]

Circulation, 2007
Background— Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apolipoprotein (apo) B–containing lipoproteins and in humans plays an important role in lipoprotein metabolism.
Hiroyuki, Tanigawa, Jeffrey T, Billheimer, Jun-ichiro, Tohyama, YuZhen, Zhang, George, Rothblat, Daniel J, Rader   +5 more
openaire   +4 more sources

Effect of unesterified cholesterol on the compartmentation of a fluorescent cholesteryl ester in a lipoprotein-like lipid microemulsion.

Journal of Lipid Research, 1992
The access of enzymes and lipid transfer proteins to neutral lipids located predominantly in the core compartment of lipoproteins may be determined to some degree by the solubility of the neutral lipids in the surface monolayer of phospholipid.
QT Li, WH Sawyer
doaj   +1 more source

Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib. [PDF]

, 2018
BackgroundEarly detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development.
DeLisle, Robert K, Ganz, Peter, Hyde, Craig, Malarstig, Anders, Murthy, Ashwin C, Ostroff, Rachel, Segal, Mark R, Weiss, Sophie J, Williams, Stephen A   +8 more
core   +2 more sources

Multiple functions of microsomal triglyceride transfer protein

Nutrition & Metabolism, 2012
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles.
Hussain M Mahmood, Rava Paul, Walsh Meghan, Rana Muhammad, Iqbal Jahangir   +4 more
doaj   +1 more source

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Role of cholesteryl ester transfer protein in reverse cholesterol transport [PDF]

Clinical Cardiology, 1991
Cholesteryl ester transfer protein (CETP) and apolipoprotein E (apo E) play important roles in reverse cholesterol transport in humans. CETP transfers cholesteryl ester (CE) from high-density lipoprotein (HDL) to other lipoproteins, mainly very low-density lipoprotein (VLDL) remnants, which provide a vehicle for the delivery of HDL-derived CE to the ...
R, McPherson, Y, Marcel
openaire   +2 more sources

Lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity from the isolated perfused rabbit liver.

Journal of Lipid Research, 1984
Lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester (CE) transfer activity accumulate linearly in the recirculated medium of the isolated perfused rabbit liver.
L De Parscau, P E Fielding
doaj   +1 more source

Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. [PDF]

, 1994
Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating
Kane, JP, Kunitake, ST, Lichenstein, H, Wright, SD, Wurfel, MM   +4 more
core   +1 more source

Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation*

Journal of Lipid Research, 2008
StarD4 protein is a member of the StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins that includes StarD5 and StarD6, proteins whose functions remain poorly defined.
Daniel Rodriguez-Agudo, Shunlin Ren, Eric Wong, Dalila Marques, Kaye Redford, Gregorio Gil, Phillip Hylemon, William M. Pandak   +7 more
doaj   +1 more source

Structure and Function of Cholesteryl Ester Transfer Protein in Cholesterol Transferring [PDF]

Biophysical Journal, 2013
Human cholesteryl ester mass can be transferred from atheroprotective high-density lipoproteins (HDL) to atherogenic low-density lipoproteins (LDL) by cholesteryl ester transfer protein (CETP), resulting higher probability of cardiovascular diseases. Finding out the mechanism of CETP in CE transferring would be an important basis and key step toward ...
Zhang, Lei, Tong, Huimin, Ren, Gang
openaire   +1 more source