Results 21 to 30 of about 53,010 (291)

Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol.

Journal of Lipid Research, 1992
Plasma cholesteryl esters, synthesized within high density lipoproteins (HDL), may be transferred from HDL particles to other lipoproteins by plasma cholesteryl ester transfer protein (CETP).
M Hannuksela, YL Marcel, YA Kesäniemi, MJ Savolainen   +3 more
doaj   +1 more source

Biochemical characterization of cholesteryl ester transfer protein inhibitors

Journal of Lipid Research, 2010
Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP.
Mollie Ranalletta, Kathleen K. Bierilo, Ying Chen, Denise Milot, Qing Chen, Elaine Tung, Caroline Houde, Nadine H. Elowe, Margarita Garcia-Calvo, Gene Porter, Suzanne Eveland, Betsy Frantz-Wattley, Mike Kavana, George Addona, Peter Sinclair, Carl Sparrow, Edward A. O'Neill, Ken S. Koblan, Ayesha Sitlani, Brian Hubbard, Timothy S. Fisher   +20 more
doaj   +1 more source

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Insulin decreases plasma cholesteryl ester transfer but not cholesterol esterification in healthy subjects as well as in normotriglyceridaemic patients with type 2 diabetes [PDF]

, 1999
Background. Plasma cholesterol esterification (EST) and subsequent cholesteryl ester transfer (CET) from high-density lipoproteins (HDLs) towards apolipoprotein (apo) B-containing lipoproteins are key steps in HDL metabolism. Materials and methods.
Dullaart, R.P.F. (Robin), Riemens, S.C., Scheek, L. (Leo), Tol, A. (Arie) van   +3 more
core   +6 more sources

Cholesteryl esters in lymph chylomicrons: contribution from high density lipoprotein transferred from plasma into intestinal lymph

Journal of Lipid Research, 1993
Most of the cholesterol in intestinal chyle and chylomicrons is derived from plasma. Our aim was to determine how much plasma low density (LDL) and high density (HDL) lipoproteins contribute to the cholesterol in chyle and chylomicrons, and to examine ...
HC Oliveira, K Nilausen, H Meinertz, EC Quintão   +3 more
doaj   +1 more source

Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion

Journal of Lipid Research, 2002
Two lipid transfer proteins are active in human plasma, cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Mice by nature do not express CETP.
Jessica Lie, Rini de Crom, Teus van Gent, Rien van Haperen, Leo Scheek, Inge Lankhuizen, Arie van Tol   +6 more
doaj   +1 more source

Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach

Frontiers in Cardiovascular Medicine, 2022
BackgroundDespite the widespread application of new drug-eluting stents, a considerable portion of patients experience in-stent restenosis (ISR). To date, the pathophysiologic mechanisms of ISR remain poorly understood.MethodsIn this study, we collected ...
Jingyuan Hou, Jingyuan Hou, Qiaoting Deng, Qiaoting Deng, Sudong Liu, Sudong Liu, Xiaohong Qiu, Xunwei Deng, Xunwei Deng, Wei Zhong, Zhixiong Zhong, Zhixiong Zhong   +11 more
doaj   +1 more source

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]

, 2014
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V., Liefhebber, Jolanda M.P., McLauchlan, John, Wakelam, Michael J.O., Zhang, Qifeng   +4 more
core   +1 more source

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

Biomolecules, 2020
We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D).
Karim G. Kheniser, Abdullah Osme, Chunki Kim, Serguei Ilchenko, Takhar Kasumov, Sangeeta R. Kashyap   +5 more
doaj   +1 more source

Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo

Journal of Lipid Research, 2008
Eight proteins potentially involved in cholesterol efflux [ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), scavenger receptor type BI (SR-BI), caveolin-1, cholesteryl ester transfer protein, and apolipoprotein A-I (apoA-I)] were ...
Nigora Mukhamedova, Genevieve Escher, Wilissa D'Souza, Urbain Tchoua, Angela Grant, Zigmund Krozowski, Michael Bukrinsky, Dmitri Sviridov   +7 more
doaj   +1 more source