Results 21 to 30 of about 23,102 (293)

Cholesteryl esters in lymph chylomicrons: contribution from high density lipoprotein transferred from plasma into intestinal lymph

Journal of Lipid Research, 1993
Most of the cholesterol in intestinal chyle and chylomicrons is derived from plasma. Our aim was to determine how much plasma low density (LDL) and high density (HDL) lipoproteins contribute to the cholesterol in chyle and chylomicrons, and to examine ...
HC Oliveira, K Nilausen, H Meinertz, EC Quintão   +3 more
doaj   +1 more source

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain

Journal of Lipid Research, 2022
The cholesteryl ester transfer protein (CETP) is a lipid transfer protein responsible for the exchange of cholesteryl esters and triglycerides between lipoproteins. Decreased CETP activity is associated with longevity, cardiovascular health, and maintenance of good cognitive performance. Interestingly, mice lack the CETP-encoding gene and have very low
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter   +9 more
openaire   +4 more sources

Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins

, 2007
Purpose of review Type 2 diabetes frequently coincides with dyslipidemia, characterized by elevated plasma triglycerides, low high-density lipoprotein cholesterol levels and the presence of small dense low-density lipoprotein particles.
Tol, Aad, van Tol, Arie, Dallinga-Thie, Geesje M., Dallinga-Thie, GM, Dullaart, RPF, Dullaart, Robin P. F.   +5 more
core   +2 more sources

Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach

Frontiers in Cardiovascular Medicine, 2022
BackgroundDespite the widespread application of new drug-eluting stents, a considerable portion of patients experience in-stent restenosis (ISR). To date, the pathophysiologic mechanisms of ISR remain poorly understood.MethodsIn this study, we collected ...
Jingyuan Hou, Jingyuan Hou, Qiaoting Deng, Qiaoting Deng, Sudong Liu, Sudong Liu, Xiaohong Qiu, Xunwei Deng, Xunwei Deng, Wei Zhong, Zhixiong Zhong, Zhixiong Zhong   +11 more
doaj   +1 more source

Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]

, 2010
The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter, Günter Müller
core   +1 more source

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

Biomolecules, 2020
We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D).
Karim G. Kheniser, Abdullah Osme, Chunki Kim, Serguei Ilchenko, Takhar Kasumov, Sangeeta R. Kashyap   +5 more
doaj   +1 more source

Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo

Journal of Lipid Research, 2008
Eight proteins potentially involved in cholesterol efflux [ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), scavenger receptor type BI (SR-BI), caveolin-1, cholesteryl ester transfer protein, and apolipoprotein A-I (apoA-I)] were ...
Nigora Mukhamedova, Genevieve Escher, Wilissa D'Souza, Urbain Tchoua, Angela Grant, Zigmund Krozowski, Michael Bukrinsky, Dmitri Sviridov   +7 more
doaj   +1 more source

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor [PDF]

ACS Medicinal Chemistry Letters, 2019
Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmaceutical properties concomitant with retaining the safety, efficacy, and ...
Heather J. Finlay, Ji Jiang, Richard Rampulla, Mark E. Salvati, Jennifer X. Qiao, Tammy C. Wang, R. Michael Lawrence, Lalgudi S. Harikrishnan, Muthoni G. Kamau, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Christine S. Huang, Ming Chang, Xue-Qing Chen, Paul G. Sleph, Carrie Xu, Julia Li, Paul Levesque, Leonard P. Adam, Ruth R. Wexler   +20 more
openaire   +2 more sources

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase

Journal of Lipid Research, 2008
Human atherosclerotic intima contains mast cells that secrete the neutral protease chymase into the intimal fluid, which also contains HDL-modifying proteins, such as cholesteryl ester transfer protein (CETP), in addition to abundant amounts of nascent ...
Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Matti Jauhiainen, Petri T. Kovanen   +4 more
doaj   +1 more source

Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities

Journal of Lipid Research, 1998
We have previously reported that normolipidemic smokers are lipid intolerant due to increased responses of triglyceride-rich lipoproteins (TRL) apolipoprotein B-48, triglyceride (TG), and retinyl esters to a mixed meal compared to non-smokers.
N. Mero, A. Van Tol, L.M. Scheek, T. Van Gent, C. Labeur, M. Rosseneu, M-R. Taskinen   +6 more
doaj   +1 more source