Results 21 to 30 of about 22,985 (252)

Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo

Journal of Lipid Research, 2008
Eight proteins potentially involved in cholesterol efflux [ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), scavenger receptor type BI (SR-BI), caveolin-1, cholesteryl ester transfer protein, and apolipoprotein A-I (apoA-I)] were ...
Nigora Mukhamedova, Genevieve Escher, Wilissa D'Souza, Urbain Tchoua, Angela Grant, Zigmund Krozowski, Michael Bukrinsky, Dmitri Sviridov   +7 more
doaj   +1 more source

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase

Journal of Lipid Research, 2008
Human atherosclerotic intima contains mast cells that secrete the neutral protease chymase into the intimal fluid, which also contains HDL-modifying proteins, such as cholesteryl ester transfer protein (CETP), in addition to abundant amounts of nascent ...
Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Matti Jauhiainen, Petri T. Kovanen   +4 more
doaj   +1 more source

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain

Journal of Lipid Research, 2022
The cholesteryl ester transfer protein (CETP) is a lipid transfer protein responsible for the exchange of cholesteryl esters and triglycerides between lipoproteins. Decreased CETP activity is associated with longevity, cardiovascular health, and maintenance of good cognitive performance. Interestingly, mice lack the CETP-encoding gene and have very low
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter   +9 more
openaire   +4 more sources

Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities

Journal of Lipid Research, 1998
We have previously reported that normolipidemic smokers are lipid intolerant due to increased responses of triglyceride-rich lipoproteins (TRL) apolipoprotein B-48, triglyceride (TG), and retinyl esters to a mixed meal compared to non-smokers.
N. Mero, A. Van Tol, L.M. Scheek, T. Van Gent, C. Labeur, M. Rosseneu, M-R. Taskinen   +6 more
doaj   +1 more source

Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism[S]

Journal of Lipid Research, 2010
Steroidogenic acute regulatory protein (StAR)D4 is a member of the StAR related lipid transfer family. Homology comes from the ∼210 amino acid lipid binding domain implicated in intracellular transport, cell signaling, and lipid metabolism.
Joshua J. Riegelhaupt, Marc P. Waase, Jeanne Garbarino, Daniel E. Cruz, Jan L. Breslow   +4 more
doaj   +1 more source

Polymorphisms at the apoB, apoA-I, and cholesteryl ester transfer protein gene loci in patients with gallbladder disease.

Journal of Lipid Research, 1995
Alterations in lipoprotein levels are reported to be related to an increased risk of gallstones. Plasma lipid metabolism is regulated by a number of proteins that are polymorphic in the population.
T Juvonen, M J Savolainen, M I Kairaluoma, L H Lajunen, S E Humphries, Y A Kesäniemi   +5 more
doaj   +1 more source

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor [PDF]

ACS Medicinal Chemistry Letters, 2019
Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmaceutical properties concomitant with retaining the safety, efficacy, and ...
Heather J. Finlay, Ji Jiang, Richard Rampulla, Mark E. Salvati, Jennifer X. Qiao, Tammy C. Wang, R. Michael Lawrence, Lalgudi S. Harikrishnan, Muthoni G. Kamau, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Christine S. Huang, Ming Chang, Xue-Qing Chen, Paul G. Sleph, Carrie Xu, Julia Li, Paul Levesque, Leonard P. Adam, Ruth R. Wexler   +20 more
openaire   +2 more sources

The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis

Journal of Lipid Research, 2009
The plasma lipid transfer proteins promote the exchange of neutral lipids and phospholipids between the plasma lipoproteins. Cholesteryl ester transfer protein (CETP) facilitates the removal of cholesteryl esters from HDL and thus reduces HDL levels ...
David Masson, Xian-Cheng Jiang, Laurent Lagrost, Alan R. Tall   +3 more
doaj   +1 more source

Periodontitis decreases the antiatherogenic potency of high density lipoprotein

Journal of Lipid Research, 2004
Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic
Pirkko J. Pussinen, Matti Jauhiainen, Tiina Vilkuna-Rautiainen, Jouko Sundvall, Marja Vesanen, Kimmo Mattila, Timo Palosuo, Georg Alfthan, Sirkka Asikainen   +8 more
doaj   +1 more source

Preparation and incorporation of probe-labeled apoA-I for fluorescence resonance energy transfer studies of rHDL

Journal of Lipid Research, 2001
Apolipoprotein A-I (apoA-I), the major constituent of HDL, plays an essential role in regulating cholesterol metabolism, acting as the physiological activator of lecithin: cholesterol acyltransferase, which converts cholesterol to cholesterol ester ...
Hui-hua Li, Michael J. Thomas, Wei Pan, Eric Alexander, Michael Samuel, Mary G. Sorci-Thomas   +5 more
doaj   +1 more source