Results 11 to 20 of about 75,561 (275)
Cholesterol Efflux and Reverse Cholesterol Transport [PDF]
, 2014 Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda +5 more
openaire +6 more sources
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]
Endocrinology and Metabolism, 2017 Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
doaj +3 more sources
Reverse cholesterol transport revisited. [PDF]
World journal of gastroenterology, 2011 Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight,
Gemma, Brufau +2 more
core +5 more sources
Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. [PDF]
PLoS ONE, 2017 This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport.
Souade Ikhlef +4 more
doaj +2 more sources
Cyclosporine A impairs the macrophage reverse cholesterol transport in mice by reducing sterol fecal excretion. [PDF]
PLoS ONE, 2013 Despite the efficacy in reducing acute rejection events in organ transplanted subjects, long term therapy with cyclosporine A is associated with increased atherosclerotic cardiovascular morbidity.
Ilaria Zanotti +7 more
doaj +3 more sources
Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent Advances in Reverse Cholesterol Transport [PDF]
Annals of Hepatology, 2017 Atherosclerosis is characterized by lipid accumulation, inflammatory response, cell death and fibrosis in the arterial wall, and is a major pathological basis for ischemic coronary heart disease (CHD), which is the leading cause of morbidity and ...
Helen H. Wang +4 more
doaj +2 more sources
HDL and Reverse Cholesterol Transport Biomarkers. [PDF]
Methodist Debakey Cardiovasc J, 2019 High-density lipoprotein (HDL) is a protein-lipid nanoparticle that has predominately been characterized by its cholesterol concentration (HDL-C). Recent studies have challenged the presumed inverse association between HDL-C and cardiovascular events, suggesting a more U-shaped association.
Riggs KA, Rohatgi A.
europepmc +4 more sources
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Nature Communications, 2017 Activation of brown adipose tissue (BAT) reduces the development of atherosclerosis in animal models. Here the authors show that BAT activation also increases reverse cholesterol transport and turnover of high-density lipoprotein, which likely ...
Alexander Bartelt +19 more
doaj +2 more sources
Reverse cholesterol transport [PDF]
Cor et Vasa, 2006 Atherosclerosis, the accumulation of cholesterol in the arteries resulting in heart attacks and strokes, is the leading cause of death in the USA and most other industrialized countries in the world. Plasma levels of high-density lipoprotein (HDL) cholesterol are invariably found to be inversely associated with the risk of atherosclerosis.
Ivana Králová Lesná +2 more
openaire +2 more sources
HDL Functions—Current Status and Future Perspectives
Biomolecules, 2023 Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically ...
Yasuhiro Endo +2 more
doaj +1 more source