Is reverse cholesterol transport regulated by active cholesterol? [PDF]
Journal of Lipid Research, 2023 This review considers the hypothesis that a small portion of plasma membrane cholesterol regulates reverse cholesterol transport in coordination with overall cellular homeostasis.
Theodore L. Steck, Yvonne Lange
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Apoprotein E and Reverse Cholesterol Transport [PDF]
International Journal of Molecular Sciences, 2018 Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions, apoE is involved in cholesterol efflux, especially from cholesterol-loaded macrophage foam cells and ...
Catherine Reardon, Godfrey S Getz
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HDL and Reverse Cholesterol Transport [PDF]
Circulation Research, 2019 Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the leading cause of death worldwide. It is well established that cholesterol ester-enriched foam cells are the hallmark of atherosclerotic plaques. Multiple lines of evidence support that enhancing foam cell cholesterol efflux by HDL (high-density lipoprotein ...
Edward Fisher +2 more
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Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy [PDF]
Journal of Diabetes Research, 2021 Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body.
Xinyuan Zhang +3 more
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Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives [PDF]
Cardiovascular Therapeutics, 2022 Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu +3 more
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Reverse cholesterol transport and hepatic osteodystrophy. [PDF]
Cell Metab, 2022 In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic ...
Zaidi M, Yuen T, Iqbal J.
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PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia [PDF]
JACC: Basic to Translational ScienceSummary: We investigated the potential of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies to restore macrophage cholesterol efflux in subjects with heterozygous familial hypercholesterolemia (FH) and to enhance the macrophage-specific ...
Carla Borràs, MSc +18 more
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MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George +10 more
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The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs
Biology, 2015 MicroRNAs (miRNAs) are small, non-coding RNAs that have the ability to post-transcriptionally regulate gene expression. Hundreds of miRNAs have been identified in humans and they are involved in the regulation of almost every process, including ...
Diana M. DiMarco, Maria Luz Fernandez
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HDL and Reverse Cholesterol Transport Biomarkers. [PDF]
Methodist Debakey Cardiovasc J, 2019 High-density lipoprotein (HDL) is a protein-lipid nanoparticle that has predominately been characterized by its cholesterol concentration (HDL-C). Recent studies have challenged the presumed inverse association between HDL-C and cardiovascular events, suggesting a more U-shaped association.
Riggs KA, Rohatgi A.
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