Results 21 to 30 of about 75,561 (275)

Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]

QJM: An International Journal of Medicine, 2005
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi, H, Mu, X, Wang, Q, Yao, C, Chen   +4 more
openaire   +2 more sources

Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]

, 2012
This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core   +1 more source

Molecular physiology of reverse cholesterol transport.

Journal of Lipid Research, 1995
Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly ...
C J Fielding, P E Fielding
doaj   +1 more source

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

Journal of Lipid Research, 2000
The properties of the mature and pro-forms of recombinant apolipoprotein A-I (apoA-I) were compared with those of apoA-I isolated from human plasma.
Dmitri Sviridov, Louise E. Pyle, Matti Jauhiainen, Christian Ehnholm, Noel H. Fidge   +4 more
doaj   +1 more source

A New Frontier for Reverse Cholesterol Transport [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Numerous epidemiological studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk.1 However, despite intense efforts to develop new pharmacological strategies to increase HDL-C levels, such as with niacin and cholesteryl ester transfer protein inhibitors, few robust ...
Kazuhiro, Nakaya, Shunichi, Takiguchi, Katsunori, Ikewaki   +2 more
openaire   +2 more sources

Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport

Journal of Lipid Research, 2010
Previous studies have shown that cholesterol in atherosclerotic plaques is present in both intracellular and extracellular forms. In the current study, we investigated a mechanism for extracellular cholesterol accumulation and examined the capacity of ...
Daniel S. Ong, Joshua J. Anzinger, Francisco J. Leyva, Noa Rubin, Lia Addadi, Howard S. Kruth   +5 more
doaj   +1 more source

Tachometer for Reverse Cholesterol Transport? [PDF]

Journal of the American Heart Association, 2012
Many clinical and epidemiological studies, as well as meta-analyses thereof, have shown the inverse relationship of high-density lipoprotein cholesterol (HDL-C) and apoliopoprotein (apo) A-I plasma levels with the risk of coronary artery disease.[1][1] HDL particles and their protein and ...
openaire   +5 more sources

Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. [PDF]

PLoS Biology, 2006
Several steps of HIV-1 replication critically depend on cholesterol. HIV infection is associated with profound changes in lipid and lipoprotein metabolism and an increased risk of coronary artery disease.
Zahedi Mujawar, Honor Rose, Matthew P Morrow, Tatiana Pushkarsky, Larisa Dubrovsky, Nigora Mukhamedova, Ying Fu, Anthony Dart, Jan M Orenstein, Yuri V Bobryshev, Michael Bukrinsky, Dmitri Sviridov   +11 more
doaj   +1 more source

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

Journal of Lipid Research, 2003
The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for removal.
Federica Basso, Lita Freeman, Catherine L. Knapper, Alan Remaley, John Stonik, Edward B. Neufeld, Terese Tansey, Marcelo J.A. Amar, Jamila Fruchart-Najib, Nicholas Duverger, Silvia Santamarina-Fojo, H.Bryan Brewer, Jr.   +11 more
doaj   +1 more source

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

Journal of Lipid Research, 2009
Peroxisome proliferator-activated receptor delta (PPARδ) is involved in regulation of energy homeostasis. Activation of PPARδ markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport.
Carlos L.J. Vrins, Astrid E. van der Velde, Karin van den Oever, Johannes H.M. Levels, Stephane Huet, Ronald P.J. Oude Elferink, Folkert Kuipers, Albert K. Groen   +7 more
doaj   +1 more source