Results 21 to 30 of about 73,387 (251)
Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway [PDF]
Drug Design, Development and Therapy, 2021 Yingnan Zhao,1,2 Yanping Li,2 Qinhui Liu,1 Qin Tang,1,2 Zijing Zhang,1,2 Jinhang Zhang,1,2 Cuiyuan Huang,1,2 Hui Huang,1,2 Guorong Zhang,1,2 Jian Zhou,1,2 Jiamin Yan,1,2 Yan Xia,1,2 Zhiyong Zhang,1,2 Jinhan He1,2 1Department of Pharmacy, National ...
Zhao Y +13 more
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Reverse cholesterol transport [PDF]
Cor et Vasa, 2006 Atherosclerosis, the accumulation of cholesterol in the arteries resulting in heart attacks and strokes, is the leading cause of death in the USA and most other industrialized countries in the world. Plasma levels of high-density lipoprotein (HDL) cholesterol are invariably found to be inversely associated with the risk of atherosclerosis.
Ivana Králová Lesná +2 more
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HDL Functions—Current Status and Future Perspectives
Biomolecules, 2023 Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically ...
Yasuhiro Endo +2 more
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Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]
QJM: An International Journal of Medicine, 2005 Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi +4 more
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Cholesterol Efflux and Reverse Cholesterol Transport [PDF]
, 2014 Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda +5 more
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Molecular physiology of reverse cholesterol transport.
Journal of Lipid Research, 1995 Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly ...
C J Fielding, P E Fielding
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Journal of Lipid Research, 2000 The properties of the mature and pro-forms of recombinant apolipoprotein A-I (apoA-I) were compared with those of apoA-I isolated from human plasma.
Dmitri Sviridov +4 more
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A New Frontier for Reverse Cholesterol Transport [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Numerous epidemiological studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk.1 However, despite intense efforts to develop new pharmacological strategies to increase HDL-C levels, such as with niacin and cholesteryl ester transfer protein inhibitors, few robust ...
Kazuhiro, Nakaya +2 more
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Tachometer for Reverse Cholesterol Transport? [PDF]
Journal of the American Heart Association, 2012 Many clinical and epidemiological studies, as well as meta-analyses thereof, have shown the inverse relationship of high-density lipoprotein cholesterol (HDL-C) and apoliopoprotein (apo) A-I plasma levels with the risk of coronary artery disease.[1][1] HDL particles and their protein and ...
openaire +5 more sources
Journal of Lipid Research, 2010 Previous studies have shown that cholesterol in atherosclerotic plaques is present in both intracellular and extracellular forms. In the current study, we investigated a mechanism for extracellular cholesterol accumulation and examined the capacity of ...
Daniel S. Ong +5 more
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