Results 21 to 30 of about 144,135 (296)

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice [PDF]

, 2013
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma.
Bittman, Robert, Chen, Shu-Hsia, Fulp, Brian, Gautier, Emmanuel, Kreisel, Daniel, Li, Wenjun, Martel, Catherine, Platt, Andrew M, Randolph, Gwendalyn J, Sorci-Thomas, Mary G, Swartz, Melody A, Tall, Alan R, Thomas, Michael J, Westerterp, Marit   +13 more
core   +5 more sources

Reverse cholesterol transport revisited. [PDF]

World journal of gastroenterology, 2011
Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight,
Gemma, Brufau, Albert K, Groen, Folkert, Kuipers   +2 more
openaire   +4 more sources

Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport

Journal of Lipid Research, 2010
Previous studies have shown that cholesterol in atherosclerotic plaques is present in both intracellular and extracellular forms. In the current study, we investigated a mechanism for extracellular cholesterol accumulation and examined the capacity of ...
Daniel S. Ong, Joshua J. Anzinger, Francisco J. Leyva, Noa Rubin, Lia Addadi, Howard S. Kruth   +5 more
doaj   +1 more source

Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. [PDF]

PLoS Biology, 2006
Several steps of HIV-1 replication critically depend on cholesterol. HIV infection is associated with profound changes in lipid and lipoprotein metabolism and an increased risk of coronary artery disease.
Zahedi Mujawar, Honor Rose, Matthew P Morrow, Tatiana Pushkarsky, Larisa Dubrovsky, Nigora Mukhamedova, Ying Fu, Anthony Dart, Jan M Orenstein, Yuri V Bobryshev, Michael Bukrinsky, Dmitri Sviridov   +11 more
doaj   +1 more source

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

Journal of Lipid Research, 2003
The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for removal.
Federica Basso, Lita Freeman, Catherine L. Knapper, Alan Remaley, John Stonik, Edward B. Neufeld, Terese Tansey, Marcelo J.A. Amar, Jamila Fruchart-Najib, Nicholas Duverger, Silvia Santamarina-Fojo, H.Bryan Brewer, Jr.   +11 more
doaj   +1 more source

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]

Endocrinology and Metabolism, 2017
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
doaj   +1 more source

Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]

, 2017
Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H., Charles, Philip D., Dowle, Adam A., Geoghegan, Vincent, Hester, Svenja, Larson, Tony, Rainey, Stephanie M., Sinkins, Steven P., Stainton, Kirsty, Thomas, Benjamin   +9 more
core   +3 more sources

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

Journal of Lipid Research, 2009
Peroxisome proliferator-activated receptor delta (PPARδ) is involved in regulation of energy homeostasis. Activation of PPARδ markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport.
Carlos L.J. Vrins, Astrid E. van der Velde, Karin van den Oever, Johannes H.M. Levels, Stephane Huet, Ronald P.J. Oude Elferink, Folkert Kuipers, Albert K. Groen   +7 more
doaj   +1 more source

Importance of macrophage cholesterol content on the flux of cholesterol mass

Journal of Lipid Research, 2010
Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan, Margarita de la Llera-Moya, Denise Drazul-Schrader, Bela F. Asztalos, Ginny L. Weibel, George H. Rothblat   +5 more
doaj   +1 more source