Results 41 to 50 of about 75,561 (275)
ABCA1: the gatekeeper for eliminating excess tissue cholesterol
Journal of Lipid Research, 2001 It is widely believed that HDL functions to transport cholesterol from peripheral cells to the liver by reverse cholesterol transport, a pathway that may protect against atherosclerosis by clearing excess cholesterol from arterial cells.
John F. Oram, Richard M. Lawn
doaj +1 more source
High density lipoprotein – a hero, a mirage or a witness?
Frontiers in Cardiovascular Medicine, 2014 Negative relationship between plasma High Density Lipoprotein (HDL) levels and risk of cardiovascular disease is a firmly established medical fact, but attempts to reproduce protective properties of HDL by pharmacologically elevating HDL levels were ...
Dmitri eSviridov
doaj +1 more source
P2Y13 Receptor Is Critical for Reverse Cholesterol Transport [PDF]
Hepatology, 2010 A major atheroprotective functionality of high-density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT). In this process, HDLs mediate the efflux and transport of cholesterol from peripheral cells and its subsequent transport to the liver for further metabolism and ...
Fabre, Aurélie +16 more
openaire +5 more sources
Insulin Regulation of Reverse Cholesterol Transport
, 2019 Insulin resistance and type 2 diabetes are pathogenetically linked to increased risk of cardiovascular disease. While insulin resistance is defined by a dysregulation in hepatic insulin signaling, it is unclear how this impairment relates to the ...
Lee, Samuel
core +1 more source
2nd International Symposium on Reverse Cholesterol Transport: report on a meeting.
Journal of Lipid Research, 1994 The purpose of this symposium was to provide a forum for presenting recent findings and for exchange of ideas concerning reverse cholesterol transport.
A G Lacko, P H Pritchard
doaj +1 more source
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Biomolecules, 2022 ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to cholesterol metabolism, several studies have assessed the impact of ABCA1 and ...
Ikechukwu Esobi +3 more
doaj +1 more source
Alcohol consumption stimulates early steps in reverse cholesterol transport
Journal of Lipid Research, 2001 Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known.
M.S. van der Gaag +5 more
doaj +1 more source
Macrophage Reverse Cholesterol Transport [PDF]
Circulation, 2006 The concept of “reverse cholesterol transport” (RCT) was first introduced in 1968 by Glomset1 to describe the process by which extrahepatic (peripheral) cholesterol is returned to the liver for excretion in the bile and ultimately the feces. The physiological need for this process is clear, as nonhepatic cells acquire cholesterol through uptake of ...
Marina, Cuchel, Daniel J, Rader
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source