High density lipoprotein – a hero, a mirage or a witness?
Frontiers in Cardiovascular Medicine, 2014 Negative relationship between plasma High Density Lipoprotein (HDL) levels and risk of cardiovascular disease is a firmly established medical fact, but attempts to reproduce protective properties of HDL by pharmacologically elevating HDL levels were ...
Dmitri eSviridov
doaj +1 more source
Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels [PDF]
, 2015 Background: Geraniol (G) is a natural isoprenoid present in the essential oils of several aromatic plants, with various biochemical and pharmacologic properties.
Castro, Maria Agustina +7 more
core +2 more sources
2nd International Symposium on Reverse Cholesterol Transport: report on a meeting.
Journal of Lipid Research, 1994 The purpose of this symposium was to provide a forum for presenting recent findings and for exchange of ideas concerning reverse cholesterol transport.
A G Lacko, P H Pritchard
doaj +1 more source
Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]
, 2019 Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G +11 more
core +3 more sources
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Biomolecules, 2022 ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to cholesterol metabolism, several studies have assessed the impact of ABCA1 and ...
Ikechukwu Esobi +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Alcohol consumption stimulates early steps in reverse cholesterol transport
Journal of Lipid Research, 2001 Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known.
M.S. van der Gaag +5 more
doaj +1 more source
High density lipoproteins and reverse cholesterol transport [PDF]
, 1992 The e>:periments described in this thesis were performed in order to clarify the mechanism of efflux of cellular cholesterol, a key step in reverse cholesterol transport.
Kilsdonk, E.P.C. (Liesbeth)
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]
, 2013 <p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth +42 more
core +1 more source