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Selecting Selective Suppressors of Selective Uptake [PDF]
Chemistry & Biology, 2003 Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that mediates the selective uptake of HDL cholesteryl ester (CE) and the bidirectional flux of free cholesterol (FC). The identification of selective uptake inhibitors holds promise for mechanistic studies of SR-BI and for discovery of pharmaceuticals useful in therapy of ...
Williams, David L
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Journal of Lipid Research, 1998 In this study the effect of lipoprotein lipase (LPL) on the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by hepatic cells was investigated.
Franz Rinninger +5 more
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Journal of Lipid Research, 2012 Macrophage foam cells are a defining pathologic feature of atherosclerotic lesions. Recent studies have demonstrated that at high concentrations associated with hypercholesterolemia, native LDL induces macrophage lipid accumulation.
Jason M. Meyer +3 more
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Cell-particles interaction – selective uptake and transport of microdiamonds
Communications BiologyDiamond particles have recently emerged as novel agents in cellular studies because of their superb biocompatibility. Their unique characteristics, including small size and the presence of fluorescent color centers, stimulate many important applications.
Armin M. Ebrahimi +3 more
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Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions
Journal of Lipid Research, 2021 : HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May +3 more
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Journal of Lipid Research, 2005 The physiological role of murine scavenger receptor class B type I (SR-BI) was evaluated by in vivo clearances of human HDL3 and LDL in normal and SR-BI knockout (KO) mice.
Mathieu R. Brodeur +4 more
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LDL and HDL enriched in triglyceride promote abnormal cholesterol transport
Journal of Lipid Research, 2002 Hypertriglyceridemia induces multiple changes in lipoprotein composition. Here we investigate how one of these modifications, triglyceride (TG) enrichment, affects HDL and LDL function when this alteration occurs under conditions in which more polar ...
Josephine W. Skeggs, Richard E. Morton
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Scavenger receptor class B type I localizes to a late endosomal compartment
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues.
Malika Ahras, Thet Naing, Ruth McPherson
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Effects of amino acid substitutions at glycine 420 on SR-BI cholesterol transport function
Journal of Lipid Research, 2007 Scavenger receptor class B type I (SR-BI) facilitates the uptake of HDL cholesteryl esters (CEs) in a two-step process involving binding of HDL to its extracellular domain and transfer of HDL core CEs to a metabolically active membrane pool, where they ...
Saj Parathath +7 more
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Journal of Lipid Research, 2008 Neutral cholesteryl ester hydrolase (CEH)-mediated hydrolysis of cellular cholesteryl esters (CEs) is required not only to generate free cholesterol (FC) for efflux from macrophages but also to release FC from lipoprotein-delivered CE in the liver for ...
Bin Zhao, Jingmei Song, Shobha Ghosh
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