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Growing gold nanostructures for shape-selective cellular uptake [PDF]
Nanoscale Research Letters, 2018 With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with cancer cells.
Sulalit Bandyopadhyay +7 more
doaj +6 more sources
Statin-dye conjugates for selective targeting of KRAS mutant cancer cells. [PDF]
PLoS ONEOver 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations (KRASMUT), for which current treatment options are limited. Statins, commonly used to lower cholesterol, have demonstrated certain selective toxicity towards KRAS ...
Hye-Ran Moon +9 more
doaj +2 more sources
Cell-particles interaction – selective uptake and transport of microdiamonds
Communications BiologyDiamond particles have recently emerged as novel agents in cellular studies because of their superb biocompatibility. Their unique characteristics, including small size and the presence of fluorescent color centers, stimulate many important applications.
Armin M. Ebrahimi +3 more
doaj +4 more sources
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions
Journal of Lipid Research, 2021 : HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May +3 more
doaj +1 more source
Journal of Lipid Research, 2005 The physiological role of murine scavenger receptor class B type I (SR-BI) was evaluated by in vivo clearances of human HDL3 and LDL in normal and SR-BI knockout (KO) mice.
Mathieu R. Brodeur +4 more
doaj +1 more source
Selecting Selective Suppressors of Selective Uptake [PDF]
Chemistry & Biology, 2003 Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that mediates the selective uptake of HDL cholesteryl ester (CE) and the bidirectional flux of free cholesterol (FC). The identification of selective uptake inhibitors holds promise for mechanistic studies of SR-BI and for discovery of pharmaceuticals useful in therapy of ...
openaire +2 more sources
New developments in selective cholesteryl ester uptake [PDF]
Current Opinion in Lipidology, 2013 Selective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly understood. This review provides a brief overview of SLU mediated by the HDL receptor scavenger receptor B-type I (SR-BI), and highlights several surprising new findings related to the impact of SLU ...
Jason M, Meyer +2 more
openaire +2 more sources
LDL and HDL enriched in triglyceride promote abnormal cholesterol transport
Journal of Lipid Research, 2002 Hypertriglyceridemia induces multiple changes in lipoprotein composition. Here we investigate how one of these modifications, triglyceride (TG) enrichment, affects HDL and LDL function when this alteration occurs under conditions in which more polar ...
Josephine W. Skeggs, Richard E. Morton
doaj +1 more source
Cardio-Protection Afforded by Β-Blockade Is Maintained During Resistance Exercise [PDF]
, 2017 Objectives Whether or not the cardio-protective effect of β-adrenergic blockade is retained during resistance exercise has not been systematically evaluated.
Conviser, Jason M. +3 more
core +2 more sources
Selective Targeting to Glioma with Nucleic Acid Aptamers [PDF]
, 2015 Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor.
Alder, Jane Elizabeth +7 more
core +6 more sources