Results 1 to 10 of about 298,238 (306)

Selecting Selective Suppressors of Selective Uptake [PDF]

Chemistry & Biology, 2003
Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that mediates the selective uptake of HDL cholesteryl ester (CE) and the bidirectional flux of free cholesterol (FC). The identification of selective uptake inhibitors holds promise for mechanistic studies of SR-BI and for discovery of pharmaceuticals useful in therapy of ...
Williams, David L
openaire   +3 more sources

Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture

Journal of Lipid Research, 1998
In this study the effect of lipoprotein lipase (LPL) on the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by hepatic cells was investigated.
Franz Rinninger, Tatjana Kaiser, W. Alexander Mann, Nicolette Meyer, Heiner Greten, Ulrike Beisiegel   +5 more
doaj   +3 more sources

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation

Journal of Lipid Research, 2012
Macrophage foam cells are a defining pathologic feature of atherosclerotic lesions. Recent studies have demonstrated that at high concentrations associated with hypercholesterolemia, native LDL induces macrophage lipid accumulation.
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj   +3 more sources

Statin-dye conjugates for selective targeting of KRAS mutant cancer cells. [PDF]

PLoS ONE
Over 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations (KRASMUT), for which current treatment options are limited. Statins, commonly used to lower cholesterol, have demonstrated certain selective toxicity towards KRAS ...
Hye-Ran Moon, Zhenying Cai, Bo Kyung Cho, Hyeyoun Chang, Seung Taek Hong, Jean J Zhao, Ick Chan Kwon, Thomas M Roberts, Bumsoo Han, Ju Hee Ryu   +9 more
doaj   +2 more sources

Cell-particles interaction – selective uptake and transport of microdiamonds

Communications Biology
Diamond particles have recently emerged as novel agents in cellular studies because of their superb biocompatibility. Their unique characteristics, including small size and the presence of fluorescent color centers, stimulate many important applications.
Armin M. Ebrahimi, Wojciech Gawlik, Adam M. Wojciechowski, Zenon Rajfur   +3 more
doaj   +4 more sources

Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions

Journal of Lipid Research, 2021
: HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May, Jacqueline S. Dron, Robert A. Hegele, Daisy Sahoo   +3 more
doaj   +1 more source

Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice

Journal of Lipid Research, 2002
Scavenger receptor BI (SR-BI) is a multi-ligand lipoprotein receptor that mediates selective lipid uptake from HDL, and plays a central role in hepatic HDL metabolism.
Nancy R. Webb, Maria C. de Beer, Jin Yu, Mark S. Kindy, Alan Daugherty, Deneys R. van der Westhuyzen, Frederick C. de Beer   +6 more
doaj   +1 more source

Scavenger receptor-BI is a receptor for lipoprotein(a)

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley   +9 more
doaj   +1 more source

Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice

Journal of Lipid Research, 2005
The physiological role of murine scavenger receptor class B type I (SR-BI) was evaluated by in vivo clearances of human HDL3 and LDL in normal and SR-BI knockout (KO) mice.
Mathieu R. Brodeur, Vilayphone Luangrath, Geneviève Bourret, Louise Falstrault, Louise Brissette   +4 more
doaj   +1 more source

Selective Uptake of Indocyanine Green by Reticulocytes in Circulation [PDF]

Investigative Opthalmology & Visual Science, 2003
Hyperfluorescent cells labeled with indocyanine green (ICG) have been observed in retinal and choroidal circulation using scanning laser ophthalmoscopy. It has been suggested that ICG labels leukocytes and that ICG can be used to track leukocyte movement in vivo.
Xunbin, Wei, Judith M, Runnels, Charles P, Lin   +2 more
openaire   +2 more sources