Results 31 to 40 of about 618,272 (309)

Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation [PDF]

, 2013
This work is supported by the UK Engineering Physical Sciences Research Council (EPSRC).A prevailing problem in neuroscience is the fast and targeted delivery of DNA into selected neurons.
Antkowiak, Maciej, Dholakia, Kishan, Gunn-Moore, Frank J, Miles, Gareth Brian, Torres, Maria Leilani, Witts, Emily Charlotte   +5 more
core   +1 more source

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation

Journal of Lipid Research, 2012
Macrophage foam cells are a defining pathologic feature of atherosclerotic lesions. Recent studies have demonstrated that at high concentrations associated with hypercholesterolemia, native LDL induces macrophage lipid accumulation.
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj   +1 more source

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]

, 2004
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William, Dufès, Christine, Muller, Jean-Marc, Olivier, Jean-Christophe, Schätzlein, Andreas G., Uchegbu, I.F.   +5 more
core   +1 more source

Selective gonadotrophin uptake by mouse ovarian carcinoma [PDF]

Experientia, 1972
Bei Mausen mit Granulosa- oder Theca-Tumoren wurde die Bindung von125I-HCG untersucht. Im Vergleich zur Bindung an andere Gewebe derselben Tiere konnte eine zellspezifische Bindung im Bereich der Tumoren festgestellt werden. Die Befunde werden im Zusammenhang mit der Zweizelltheorie der ovariellen Steroidgenese diskutiert.
openaire   +3 more sources

SR-BI Selective Lipid Uptake [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). Methods and Results— We used SAA and SR-BI adenoviral vector expression models to study the ...
Maria C, de Beer, Nancy R, Webb, Nathan L, Whitaker, Joanne M, Wroblewski, Anisa, Jahangiri, Deneys R, van der Westhuyzen, Frederick C, de Beer   +6 more
openaire   +2 more sources

Implications of endogenous and exogenous lipoprotein lipase for the selective uptake of HDL3-associated cholesteryl esters by mouse peritoneal macrophages

Journal of Lipid Research, 1997
To investigate the implications of endogenous LPL on selective uptake of HDL3-associated cholesteryl esters (HDL3-CEs) by mouse peritoneal macrophages (MPMs), we have performed uptake experiments with MPMs obtained from control mice and transgenic ...
U Panzenboeck, A Wintersberger, S Levak-Frank, R Zimmermann, R Zechner, G M Kostner, E Malle, W Sattler   +7 more
doaj   +1 more source

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

EJNMMI Research, 2021
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia.
Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]

, 2017
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam, Cassaday, Jason A., Cooke, Andrew J., Culberson, J. Chris, Finley, Michael, Hermes, Jeffrey D., Hurzy, Danielle, Johnson, Eric N., Kutchukian, Peter S., Magliaro, Brian C., O’Donnell, Gregory, Parmentier-Batteur, Sophie, Pascarella, Danette, Schlegel, Kelly-Ann Sondra, Squadroni, Brian, Thomson, Fiona, Uebele, Victor N., Warren, Lee, Zuck, Paul   +18 more
core   +2 more sources

Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes

Journal of Lipid Research, 2004
Previous reports attributed cholesteryl ester transfer protein (CETP)-mediated HDL cholesteryl ester (CE) selective uptake to the CETP-mediated transfer of CE from HDL to newly secreted apolipoprotein B-containing lipoproteins, which are then ...
Gerard Vassiliou, Ruth McPherson
doaj   +1 more source

Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity [PDF]

, 2014
Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent.
Lamberti, María Julia, Rivarola, Viviana, Rumie Vittar, Natalia Belen   +2 more
core   +1 more source