Results 1 to 10 of about 11,132 (198)
Cellular Localization and Trafficking of the Human ABCG1 Transporter [PDF]
Biology, 2014 We have developed a suitable heterologous cell expression system to study the localization, trafficking, and site(s) of function of the human ABCG1 transporter.
Alan Remaley +2 more
exaly +6 more sources
Heart International, 2012 The ABCG1 protein is centrally involved in reverse cholesterol transport from the vessel wall. Investigation of the effects of ABCG1 overexpression or knockdown in vivo has produced controversial results and strongly depended on the gene intervention ...
Martin Ungerer +2 more
exaly +4 more sources
Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function. [PDF]
PLoS ONE, 2018 The ABC transporter ABCG1 contributes to the regulation of cholesterol efflux from cells and to the distribution of cholesterol within cells. We showed previously that ABCG1 deficiency inhibits insulin secretion by pancreatic beta cells and, based on its
Megan T Harris +4 more
doaj +3 more sources
Frontiers in Oncology, 2018 The ATP-binding cassette transporter G1 (ABCG1) is a cholesterol lipid efflux pump whose role in tumor growth has been largely unknown. Our transcriptomics revealed that ABCG1 was powerfully expressed in rapidly metastatic, aggregative colon cancer cells,
Stuart K Calderwood +2 more
exaly +3 more sources
Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S] [PDF]
Journal of Lipid Research, 2010 ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte ...
Yan J. Jiang +8 more
doaj +3 more sources
The Effect of Eight Weeks of Aquatic Aerobic Training on ABCA1 and ABCG1 Genes Expression in the Blood Mononuclear Cells in Women After Coronary Artery Bypass Grafting [PDF]
Journal of Kerman University of Medical Sciences, 2020 Background: The aim of this research was to investigate the effect of aquatic aerobic training on regulatory factors related to Reverse Cholesterol Transport in women after coronary artery bypass grafting (CABG).
Mahdiyeh Haj Hosseini +3 more
doaj +1 more source
Protein kinase A modulates the activity of a major human isoform of ABCG1
Journal of Lipid Research, 2012 ABCG1 is an ABC half-transporter that exports cholesterol from cells to HDL. This study set out to investigate differences in posttranslational processing of two human ABCG1 protein isoforms, termed ABCG1(+12) and ABCG1(− 12), that differ by the presence
Ingrid C. Gelissen +7 more
doaj +1 more source
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Biomolecules, 2022 ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to cholesterol metabolism, several studies have assessed the impact of ABCA1 and ...
Ikechukwu Esobi +3 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC ...
Olanrewaju Oladosu +4 more
doaj +1 more source
Journal of Lipid Research, 2008 Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and ...
Braydon L. Burgess +16 more
doaj +1 more source