Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 [PDF]
Journal of Lipid Research, 2006 Cholesterol and phospholipids are essential to the body, but an excess of cholesterol or lipids is toxic and a risk factor for arteriosclerosis. ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis.
Aya Kobayashi +8 more
doaj +3 more sources
ABCG1 regulates pulmonary surfactant metabolism in mice and men[S] [PDF]
Journal of Lipid Research, 2017 Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are restricted to epithelial type 2 (T2) pneumocytes (also called T2 cells). Clearance of surfactant is
Thomas Q. de Aguiar Vallim +12 more
doaj +5 more sources
Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S] [PDF]
Journal of Lipid Research, 2010 ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte ...
Yan J. Jiang +8 more
doaj +3 more sources
SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 [PDF]
Lipids in Health and Disease, 2012 Background The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux from Chinese Hamster Ovary (CHO) cells were investigated. Results When apolipoproteinA-I (apoA-I) was used
Song Guohua +7 more
doaj +3 more sources
Expression and functional characterization of ABCG1 splice variant ABCG1(666) [PDF]
FEBS Letters, 2006 The ATP‐binding cassette transporter ABCG1 mediates the transport of excess cholesterol from macrophages and other cell types to high density lipoprotein (HDL) but not to lipid‐depleted apolipoprotein AI. Several splice variants which may have different functions have been identified in mammals.
Engel, Thomas +7 more
openaire +2 more sources
Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550—Brief Report [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Objective— In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology , it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was
Tarling, Elizabeth J, Edwards, Peter A
openaire +4 more sources
ABCG1-mediated generation of extracellular cholesterol microdomains [PDF]
Journal of Lipid Research, 2014 Previous studies have demonstrated that the ATP-binding cassette transporters (ABC)A1 and ABCG1 function in many aspects of cholesterol efflux from macrophages. In this current study, we continued our investigation of extracellular cholesterol microdomains that form during enrichment of macrophages with cholesterol.
Sebastian R. Freeman +7 more
openaire +3 more sources
Structure of the Human Cholesterol Transporter ABCG1
Journal of Molecular Biology, 2021 ABCG1 is an ATP binding cassette (ABC) transporter that removes excess cholesterol from peripheral tissues. Despite its role in preventing lipid accumulation and the development of cardiovascular and metabolic disease, the mechanism underpinning ABCG1-mediated cholesterol transport is unknown.
Skarda, Liga +2 more
openaire +3 more sources
Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3 [PDF]
, 2000 The gene that codes for the ABC transporter ABCG1 is located in a chromosomal susceptibility region (21q22.3) for affective disorders. Genetic variations in ABCG1 have been associated with affective disorders in Japanese males.
Anghelescu, I. +9 more
core +1 more source
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
core +2 more sources