Results 11 to 20 of about 11,132 (198)

ABCG1 regulates pulmonary surfactant metabolism in mice and men[S] [PDF]

Journal of Lipid Research, 2017
Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are restricted to epithelial type 2 (T2) pneumocytes (also called T2 cells). Clearance of surfactant is
Thomas Q. de Aguiar Vallim, Elinor Lee, David J. Merriott, Christopher N. Goulbourne, Joan Cheng, Angela Cheng, Ayelet Gonen, Ryan M. Allen, Elisa N.D. Palladino, David A. Ford, Tisha Wang, Ángel Baldán, Elizabeth J. Tarling   +12 more
doaj   +7 more sources

SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 [PDF]

Lipids in Health and Disease, 2012
Background The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux from Chinese Hamster Ovary (CHO) cells were investigated. Results When apolipoproteinA-I (apoA-I) was used
Song Guohua, Zong Chuanlong, Liu Qian, Si Yanhong, Liu Jie, Li Wei, Zhu Ping, Qin Shucun   +7 more
doaj   +4 more sources

Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550—Brief Report [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Objective— In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology , it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was
Tarling, Elizabeth J, Edwards, Peter A
openaire   +6 more sources

Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells. [PDF]

PLoS ONE, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Vishwaroop Mulay, Peta Wood, Melanie Manetsch, Masoud Darabi, Rose Cairns, Monira Hoque, Karen Cecilia Chan, Meritxell Reverter, Anna Alvarez-Guaita, Kerry-Anne Rye, Carles Rentero, Joerg Heeren, Carlos Enrich, Thomas Grewal   +13 more
doaj   +3 more sources

ABCG1: How critical for cholesterol transport? [PDF]

Cell Metabolism, 2005
In the current issue of Cell Metabolism, Kennedy et al. (2005) have extended our understanding of the ABCG1 transporter. Their studies demonstrate that, at least in macrophages, ABCG1 is responsible for much of the cholesterol efflux that utilizes mature HDL as an acceptor.
Shachter, Neil S.
openaire   +3 more sources

Structure and Function Studies of ABCG1 [PDF]

, 2013
ATP-binding cassette transporter G1 (ABCG1) mediates sterol efflux onto lipidated lipoproteins and plays an important role in macrophage cholesterol homeostasis. In this project, we investigated how ABCG1 works as a functional transporter to mediate sterol translocation.
Li, Ge
openaire   +2 more sources

Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis [PDF]

Endocrinology
Abstract Cholesterol is the precursor of all steroids, but how cholesterol flux is controlled in steroidogenic tissues is poorly understood. The cholesterol exporter ABCG1 is an essential component of the reverse cholesterol pathway and its global inactivation results in neutral lipid redistribution to tissue macrophages. The function of
Jani Liimatta, Evelyn Curschellas, Emre Murat Altinkilic, Rawda Naamneh Elzenaty, Philipp Augsburger, Therina du Toit, Clarissa D Voegel, David T Breault, Christa E Flück, Emanuele Pignatti   +9 more
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Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 [PDF]

Journal of Lipid Research, 2006
Cholesterol and phospholipids are essential to the body, but an excess of cholesterol or lipids is toxic and a risk factor for arteriosclerosis. ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis.
Aya Kobayashi, Yasukazu Takanezawa, Takashi Hirata, Yuji Shimizu, Keiko Misasa, Noriyuki Kioka, Hiroyuki Arai, Kazumitsu Ueda, Michinori Matsuo   +8 more
doaj   +3 more sources

Functional Cooperativity between ABCG4 and ABCG1 Isoforms [PDF]

PLOS ONE, 2016
ABCG4 belongs to the ABCG subfamily, the members of which are half transporters composed of a single transmembrane and a single nucleotide-binding domain. ABCG proteins have a reverse domain topology as compared to other mammalian ABC transporters, and have to form functional dimers, since the catalytic sites for ATP binding and hydrolysis, as well as ...
Zoltán Hegyi, László Homolya
openaire   +7 more sources

Resveratrol modulates ATPase activity of liposome‐reconstituted ABCG1 [PDF]

FEBS Letters, 2013
ABCG1 is a half‐sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols. However, it is unknown whether there are other mechanisms of up‐regulation of ABCG1 activity.
Athayde Moncorvo Collado, Alejandro de, Corbalán, Natalia, Homolya, László, Morero, Roberto, Minahk, Carlos   +4 more
openaire   +6 more sources