Results 21 to 30 of about 11,132 (198)

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity [PDF]

Nature Communications, 2015
ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival.
Sag, D., Cekic, C., Wu, R., Linden J., Hedrick, C.C.   +4 more
openaire   +7 more sources

ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin[S] [PDF]

Journal of Lipid Research, 2013
ATP-binding cassette protein G1 (ABCG1) is important for the formation of HDL. However, the biochemical properties of ABCG1 have not been reported, and the mechanism of how ABCG1 is involved in HDL formation remains unclear. We established a procedure to
Hiroshi Hirayama, Yasuhisa Kimura, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda   +4 more
doaj   +3 more sources

ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis

Journal of Pharmacological Sciences, 2022
Prevention of atherosclerosis is important because it is a risk factor for cardiovascular diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and triglycerides in peripheral cells. ATP-binding cassette protein A1 (ABCA1)
Michinori Matsuo
doaj   +3 more sources

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux

Journal of Lipid Research, 2009
Among the known mechanisms of reverse cholesterol transport (RCT), ATP binding cassette transporter G1 (ABCG1)-mediated free cholesterol (FC) transport is the most recent and least studied.
Sandhya Sankaranarayanan, John F. Oram, Bela F. Asztalos, Ashley M. Vaughan, Sissel Lund-Katz, Maria Pia Adorni, Michael C. Phillips, George H. Rothblat   +7 more
doaj   +2 more sources

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production. [PDF]

PLoS ONE, 2016
ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has ...
Osamu Sano, Maki Tsujita, Yuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, Michinori Matsuo   +9 more
doaj   +2 more sources

ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

Analytical Cellular Pathology, 2020
Summary. Oxidative stress is an important factor that is related to endothelial dysfunction. ATP-binding cassette transporter G1 (ABCG1), a regulator of intracellular cholesterol efflux, has been found to prevent endothelial activation in vessel walls ...
Jiahong Xue, Jiali Fan, Yuan Li, Wenhuan Wu, Qing Yan, Qiangsun Zheng   +5 more
doaj   +2 more sources

The Human ABCG1 Transporter Mobilizes Plasma Membrane and Late Endosomal Non-Sphingomyelin-Associated-Cholesterol for Efflux and Esterification

Biology, 2014
We have previously shown that GFP-tagged human ABCG1 on the plasma membrane (PM) and in late endosomes (LE) mobilizes sterol on both sides of the membrane lipid bilayer, thereby increasing cellular cholesterol efflux to lipid surfaces.
Edward B. Neufeld, Katherine O'Brien, Avram D. Walts, John A. Stonik, Daniela Malide, Christian A. Combs, Alan T. Remaley   +6 more
doaj   +2 more sources

Biological Functions and Clinical Significance of the ABCG1 Transporter

Biology
ATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis. ATP-binding cassette sub-family G member 1 (ABCG1) is a member of the ABCG subfamily of transporters and performs many important functions, such as the export of cholesterol and some other ...
Stanislav Kotlyarov, Anna Kotlyarova
openaire   +4 more sources

Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway. [PDF]

J Cell Mol Med
ABSTRACT The regulatory role of bone marrow in systemic metabolic processes remains incompletely characterized. Myeloid‐derived growth factor (MYDGF) is a myeloid cell‐secreted factor with emerging metabolic functions, but its action in diabetes‐associated non‐alcoholic fatty liver disease (DM NAFLD) is undefined.
Chen Z, Meng B, Wang B, Ding Y.
europepmc   +2 more sources

Structure of the Human Cholesterol Transporter ABCG1

Journal of Molecular Biology, 2021
ABCG1 is an ATP binding cassette (ABC) transporter that removes excess cholesterol from peripheral tissues. Despite its role in preventing lipid accumulation and the development of cardiovascular and metabolic disease, the mechanism underpinning ABCG1-mediated cholesterol transport is unknown.
Skarda, Liga, Kowal, Julia, Locher, Kaspar P.   +2 more
openaire   +3 more sources