Results 21 to 30 of about 15,107 (221)

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Journal of Lipid Research, 2008
Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and ...
Braydon L. Burgess, Pamela F. Parkinson, Margaret M. Racke, Veronica Hirsch-Reinshagen, Jianjia Fan, Charmaine Wong, Sophie Stukas, Louise Theroux, Jeniffer Y. Chan, James Donkin, Anna Wilkinson, Danielle Balik, Brian Christie, Judes Poirier, Dieter Lütjohann, Ronald B. DeMattos, Cheryl L. Wellington   +16 more
doaj   +1 more source

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis

Journal of Pharmacological Sciences, 2022
Prevention of atherosclerosis is important because it is a risk factor for cardiovascular diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and triglycerides in peripheral cells. ATP-binding cassette protein A1 (ABCA1)
Michinori Matsuo
doaj   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit, Aguilar-Bryan, Ashcroft, Boyden, Cassel, Clement, Dostert, Duncan, Halle, Hamon, Hoffman, Hornung, Kanneganti, Kanneganti, Laliberte, Lamkanfi, Lamkanfi, Locovei, Ma, Mariathasan, Mariathasan, Martinon, Marty, Meyer, Miki, Miki, Pelegrin, Pelegrin, Perregaux, Riddle, Rosengren, Schott, Solle, Stoller, Sutterwala, Yvan-Charvet   +43 more
core   +2 more sources

Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity [PDF]

, 2014
The role of ATP-binding Cassette G1 (ABCG1) transporter in human pathophysiology is still largely unknown. Indeed, beyond its role in mediating free cholesterol efflux to HDL, ABCG1 transporter equally promotes lipid accumulation in a triglyceride (TG ...
A. Kontush, A. Superville, C. Poitou, E. Frisdal, E.F. Villard, G.M. Dallinga-Thie, H. Hooton, I. Dugail, J. Chapman, J. Tordjman, K. Clément, L. Miftah-Alkhair, L. Poupel, M. Guerin, M. Lhomme, M. Olivier, N. Venteclef, P. Lesnik, R. Alili, S. Gilibert, S. Le Lay, T. Huby, W. Le Goff, W. Plengpanich   +23 more
core   +2 more sources

Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Journal of Cardiovascular Development and Disease, 2023
Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC ...
Olanrewaju Oladosu, Ikechukwu C. Esobi, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +4 more
doaj   +1 more source

ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

Analytical Cellular Pathology, 2020
Summary. Oxidative stress is an important factor that is related to endothelial dysfunction. ATP-binding cassette transporter G1 (ABCG1), a regulator of intracellular cholesterol efflux, has been found to prevent endothelial activation in vessel walls ...
Jiahong Xue, Jiali Fan, Yuan Li, Wenhuan Wu, Qing Yan, Qiangsun Zheng   +5 more
doaj   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources

Insight Into ABCG1-Mediated Cholesterol Efflux [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Macrophages in the arterial intima take up modified LDL and become cholesterol-ester laden foam cells, which are the primary cell type in newly formed fatty streak lesions, and which play an important role throughout lesion progression and plaque vulnerability.
openaire   +2 more sources