Results 41 to 50 of about 11,132 (198)

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis [PDF]

Background: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by alpha-ARs (alpha-adrenergic receptors). Plasma membrane cholesterol accumulation affects alpha(1)-AR signaling and promotes loss of SMC contractile ...
Jorgensen H. F., Sluimer J. C., Henning R. H., Deelman L. E., De Jong I. J., Kuipers F., Koster M. H., Schouten E. M., Bongiovanni L., Halmos B., Nakladal D., Buiten A. V., Huijkman N. C. A., De Neck S. M., Buikema H., La Rose A. M., Langelaar-Makkinje M., Groenen A. G., Bazioti V., Van Den Heuvel M. C., Westerterp M., Kloosterhuis N. J., De Bruin A., Methorst D.   +23 more
core   +4 more sources

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

Journal of Lipid Research, 2015
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and ...
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renée C. LeBoeuf   +4 more
doaj   +1 more source

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

Journal of Lipid Research, 2005
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein.
Steven L. Sabol, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo   +2 more
doaj   +1 more source

Colocalization of ABCG1 with flotillin-1.

, 2014
HEK293 cells transiently expressing ABCG1, ABCG1-KM, ABCG4, or ABCG4-KM plus flotillin-GFP were permeabilized with Triton X-100 (ABCG1) or methanol (ABCG4) and reacted with anti-ABCG1 or -ABCG4 antibodies and analyzed by confocal microscopy.
Aya Kobayashi (642543), Michinori Matsuo (169167), Shiho Ito (642542), Kazumitsu Ueda (169170), Osamu Sano (642541), Yuji Shimizu (174369), Reiko Kato (372943), Noriyuki Kioka (169174), Yasuhisa Kimura (642544), Kentaro Hanada (207598)   +9 more
core   +1 more source

ATP binding cassette G1-dependent cholesterol efflux during inflammation1

Journal of Lipid Research, 2011
ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis.
Maria C. de Beer, Ailing Ji, Anisa Jahangiri, Ashley M. Vaughan, Frederick C. de Beer, Deneys R. van der Westhuyzen, Nancy R. Webb   +6 more
doaj   +1 more source

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux. [PDF]

PLoS ONE, 2013
ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I (apoA-I), the main protein constituent of HDL, in this process is not clear.
Georgios Daniil, Vassilis I Zannis, Angeliki Chroni   +2 more
doaj   +1 more source

A Critical Role for ABCG1 in Macrophage Inflammation and Lung Homeostasis [PDF]

The Journal of Immunology, 2008
Abstract ATP-binding cassette transporter G1 (ABCG1) effluxes cholesterol from macrophages and plays an important role in pulmonary lipid homeostasis. We hypothesize that macrophages from Abcg1−/− mice have increased inflammatory activity, thereby promoting acceleration of pulmonary disease.
Allison J, Wojcik, Marcus D, Skaflen, Suseela, Srinivasan, Catherine C, Hedrick   +3 more
openaire   +2 more sources

ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages. [PDF]

PLoS ONE, 2014
ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol transporter involved in macrophage sterol homeostasis, reverse cholesterol transport (RCT), and atherosclerosis.
Fang Liu, Wei Wang, Yan Xu, Yu Wang, Lian-Feng Chen, Quan Fang, Xiao-Wei Yan   +6 more
doaj   +1 more source

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

Journal of Lipid Research, 2008
Here, we describe the initial characterization of Abcg4−/− mice and identify overlapping functions of ABCG4 and ABCG1 in the brain. Histological examination of tissues from Abcg4+/−/nlsLacZ and Abcg1+/−/nlsLacZ mice demonstrates that coexpression of ...
Paul T. Tarr, Peter A. Edwards
doaj   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source