Results 51 to 60 of about 15,107 (221)

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux. [PDF]

PLoS ONE, 2013
ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I (apoA-I), the main protein constituent of HDL, in this process is not clear.
Georgios Daniil, Vassilis I Zannis, Angeliki Chroni   +2 more
doaj   +1 more source

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.

PLoS ONE, 2016
ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has ...
Osamu Sano, Maki Tsujita, Yuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, Michinori Matsuo   +9 more
doaj   +1 more source

ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane. [PDF]

PLoS ONE, 2014
ATP-binding cassette A1 (ABCA1), ABCG1, and ABCG4 are lipid transporters that mediate the efflux of cholesterol from cells. To analyze the characteristics of these lipid transporters, we examined and compared their distributions and lipid efflux activity
Osamu Sano, Shiho Ito, Reiko Kato, Yuji Shimizu, Aya Kobayashi, Yasuhisa Kimura, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, Michinori Matsuo   +9 more
doaj   +1 more source

ABCG1 maintains high-grade glioma survival in vitro and in vivo [PDF]

, 2016
The overall survival for adults with malignant glioma (glioblastoma) remains poor despite advances in radiation and chemotherapy. One of the mechanisms by which cancer cells develop relative resistance to treatment is through de-regulation of endoplasmic
Chen, Yi-Hsien, Cimino, Patrick J, Dahiya, Sonika, Gutmann, David H, Luo, Jingqin   +4 more
core   +3 more sources

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes [PDF]

Diabetes, 2015
Diabetes exacerbates cardiovascular disease, at least in part through suppression of macrophage cholesterol efflux and levels of the cholesterol transporters ATP binding cassette transporter A1 (ABCA1) and ABCG1. The receptor for advanced glycation end products (RAGE) is highly expressed in human and murine diabetic atherosclerotic plaques ...
Daffu, Gurdip, Shen, Xiaoping, Senatus, Laura, Thiagarajan, Devi, Abedini, Andisheh, Hurtado del Pozo, Carmen, Rosario, Rosa, Song, Fei, Friedman, Richard A., Ramasamy, Ravichandran, Schmidt, Ann Marie   +10 more
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

Journal of Lipid Research, 2008
Here, we describe the initial characterization of Abcg4−/− mice and identify overlapping functions of ABCG4 and ABCG1 in the brain. Histological examination of tissues from Abcg4+/−/nlsLacZ and Abcg1+/−/nlsLacZ mice demonstrates that coexpression of ...
Paul T. Tarr, Peter A. Edwards
doaj   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation

American Journal of Respiratory Cell and Molecular Biology, 2019
Pulmonary granuloma formation is a complex and poorly understood response to inhaled pathogens and particulate matter. To explore the mechanisms of pulmonary granuloma formation and maintenance, our laboratory has developed a multiwall carbon nanotube (MWCNT)-induced murine model of chronic granulomatous inflammation.
Matthew McPeek, Anagha Malur, Debra A. Tokarz, Kvin Lertpiriyapong, Kymberly M. Gowdy, Gina Murray, Christopher J. Wingard, Michael B. Fessler, Barbara P. Barna, Mary Jane Thomassen   +9 more
openaire   +3 more sources