Results 51 to 60 of about 11,132 (198)
Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1s⃞
Journal of Lipid Research, 2007 ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver.
Osamu Sano +7 more
doaj +1 more source
ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane. [PDF]
PLoS ONE, 2014 ATP-binding cassette A1 (ABCA1), ABCG1, and ABCG4 are lipid transporters that mediate the efflux of cholesterol from cells. To analyze the characteristics of these lipid transporters, we examined and compared their distributions and lipid efflux activity
Osamu Sano +9 more
doaj +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Journal of Lipid Research, 2007 Although intracellular cholesterol levels are known to influence the proteolysis of β-amyloid precursor protein (APP), the effect of specific genes that regulate cholesterol metabolism on APP processing remains poorly understood.
Gavin H. Tansley +16 more
doaj +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Integrative Zoology, EarlyView.This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng +19 more
wiley +1 more source
, 2018 (A) Fractionation of postnuclear supernatant from INS1 cells by centrifugation on a continuous sucrose density gradient showing the broad distribution of ABCG1 but only modest overlap with higher density granule-containing fractions (10–13).
Anna M. Castle (5774291) +4 more
core +1 more source
BMC Cardiovascular Disorders, 2021 Background Recent studies have focused on the potential role of epicardial adipose tissue (EAT) in the development of coronary artery disease (CAD). ABCA1 and ABCG1 transporters regulate cell cholesterol content and reverse cholesterol transport.
Valentina V. Miroshnikova +11 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro +3 more
wiley +1 more source
Distribution of ABCA1, ABCG1, and ABCG4 between Brij 96 raft and non-raft domains.
, 2014 HEK293, HEK/ABCA1, HEK/ABCG1, HEK/ABCG1-KM, or HEK/ABCG4 cells were incubated with buffer containing 1% Brij 96 on ice. The cell lysates were separated by OptiPrep-gradient ultracentrifugation. Ten fractions of each were separated by 5–20% polyacrylamide
Aya Kobayashi (642543) +9 more
core +1 more source