Results 61 to 70 of about 11,132 (198)

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Lipids in Health and Disease, 2009
Background Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an important role in the accelerated onset of AD in DS individuals.
Eadie Brennan D, Kannangara Timal S, Parkinson Pamela F, Burgess Braydon L, Wellington Cheryl L, Christie Brian R   +5 more
doaj   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Ras/MAPK signaling modulates ABCG1 activity in CHO-ABCG1 cells.

, 2013
(A) CHO-ABCG1 cells were incubated ±10 µM PD98059 for 24 h as indicated and subjected to subcellular fractionation through Percoll gradients. Ras-containing plasma membrane fractions (PM) in the middle of the gradient were isolated and analyzed for the ...
Peta Wood (407179), Carles Rentero (47624), Joerg Heeren (291029), Meritxell Reverter (407184), Vishwaroop Mulay (407178), Anna Álvarez-Guaita (407185), Carlos Enrich (256734), Melanie Manetsch (393687), Rose Cairns (407181), Masoud Darabi (407180), Thomas Grewal (47629), Karen Cecilia Chan (407183), Monira Hoque (407182), Kerry-Anne Rye (280675)   +13 more
core   +1 more source

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Journal of Lipid Research, 2007
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung.
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio   +8 more
doaj   +1 more source

MD‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS‐STING Dependent Pathway in Macrophages

Cell Proliferation, EarlyView.
MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao, Zhili Jin, Zhiwei Cai, Quan Zhang, Tao He, Xiangjie Kong, Ming Chen, Zhibing Lu, Xiaorong Hu, Wen‐Lin Cheng   +9 more
wiley   +1 more source

Ras/MAPK inhibition reduces ABCG1 expression in CHO cells.

, 2013
(A–C) CHO-ABCG1 (A), HEK293 (B) and THP1 macrophages (C) cells were incubated ±50 µM GW3965 and 10 µM PD98059 for 24 h as indicated. Cell lysates were analyzed for ABCG1, activated Erk1/2 (P-Erk1/2), Total Erk1/2 and β-actin.
Peta Wood (407179), Carles Rentero (47624), Joerg Heeren (291029), Meritxell Reverter (407184), Vishwaroop Mulay (407178), Anna Álvarez-Guaita (407185), Carlos Enrich (256734), Melanie Manetsch (393687), Rose Cairns (407181), Masoud Darabi (407180), Thomas Grewal (47629), Karen Cecilia Chan (407183), Monira Hoque (407182), Kerry-Anne Rye (280675)   +13 more
core   +1 more source

Long Term Effect of High Intensity Interval Training and Flaxseed Oil Supplementation on the Expression of Genes Involved in Reverse Cholesterol Transport in Male Rats

Journal of Medicinal Plants, 2017
Background: The potential effect of exercise training with supplementation in improving fat metabolism and complications of lipid disorders is an interesting subject.
S Rahmati-Ahmadabad, H Shirvani, V Sobhani   +2 more
doaj  

Differential expression and function of ABCG1 and ABCG4 during development and aging[S]

Journal of Lipid Research, 2010
ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is known to be expressed in numerous cell types and tissues, whereas ABCG4 expression ...
Dragana D. Bojanic, Paul T. Tarr, Greg D. Gale, Desmond J. Smith, Dean Bok, Bryan Chen, Steven Nusinowitz, Anita Lövgren-Sandblom, Ingemar Björkhem, Peter A. Edwards   +9 more
doaj   +1 more source

Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease

Clinical Epigenetics, 2023
Background Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention.
Jialie Jin, Xiaojing Zhao, Chao Zhu, Mengxia Li, Jinxin Wang, Yao Fan, Chunlan Liu, Chong Shen, Rongxi Yang   +8 more
doaj   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source