Results 81 to 90 of about 15,107 (221)

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Lipids in Health and Disease, 2009
Background Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an important role in the accelerated onset of AD in DS individuals.
Eadie Brennan D, Kannangara Timal S, Parkinson Pamela F, Burgess Braydon L, Wellington Cheryl L, Christie Brian R   +5 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Journal of Lipid Research, 2007
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung.
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio   +8 more
doaj   +1 more source

13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages [PDF]

, 2011
Background Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver × receptor α (LXRα) and subsequent induction of cholesterol ...
Ines InesKämmerer, Robert Ringseis, Ronald Biemann, Gaiping Wen, Klaus Eder, Kämmerer, Ines   +5 more
core   +2 more sources

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Long Term Effect of High Intensity Interval Training and Flaxseed Oil Supplementation on the Expression of Genes Involved in Reverse Cholesterol Transport in Male Rats

Journal of Medicinal Plants, 2017
Background: The potential effect of exercise training with supplementation in improving fat metabolism and complications of lipid disorders is an interesting subject.
S Rahmati-Ahmadabad, H Shirvani, V Sobhani   +2 more
doaj  

Differential expression and function of ABCG1 and ABCG4 during development and aging[S]

Journal of Lipid Research, 2010
ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is known to be expressed in numerous cell types and tissues, whereas ABCG4 expression ...
Dragana D. Bojanic, Paul T. Tarr, Greg D. Gale, Desmond J. Smith, Dean Bok, Bryan Chen, Steven Nusinowitz, Anita Lövgren-Sandblom, Ingemar Björkhem, Peter A. Edwards   +9 more
doaj   +1 more source

Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis

Archives of Public Health, 2022
Background Epigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study provides a review of the current evidence on the association between methylation of some genes (LINE1 ...
Zahra Barouti, Motahar Heidari-Beni, Anahita Shabanian-Boroujeni, Morteza Mohammadzadeh, Vida Pahlevani, Parnian Poursafa, Fatemeh Mohebpour, Roya Kelishadi   +7 more
doaj   +1 more source

Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian   +6 more
wiley   +1 more source

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Journal of Lipid Research, 2006
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj   +1 more source