Results 81 to 90 of about 11,132 (198)

Charakterisierung des PAMP-induzierbaren Transporters ABCG1 aus Solanum tuberosum [PDF]

, 2016
ABCG1 kodiert für einen Plasmamembran lokalisierten ABC (ATP-bindende Kassette)-Halbtransporter der Unterfamilie G, und wurde im Rahmen von Mikroarray-Analysen als ein Kandidatengen identifiziert, dessen Transkriptakkumulation durch das Pathogen ...
Landgraf, Ramona
core   +1 more source

Establishing a Biophotonic Signature of Brain Ageing

Aging Cell, Volume 25, Issue 11, November 2026.
If we excite autofluorescence from brains with a 488 nm laser, young brain autofluorescence shows blue‐shifted spectra; aged brain autofluorescence shows red‐shifted spectra. This spectral shift is predicted by plasma SM32:2 levels. These signals allow unbiased distinction of an ageing from a young brain.
Mary Slayo, Loretta Vocale, Soniya Xavier, Pasindu Singhaarachchi, Kylie M. Quinn, Blanca del Rosal, Sarah J. Spencer   +6 more
wiley   +1 more source

Distribution of ABCA1, ABCG1, and ABCG4 between Triton X-100 raft and non-raft domains.

, 2014
HEK293, HEK/ABCA1, HEK/ABCG1, HEK/ABCG1-KM, or HEK/ABCG4 cells (A) or SH-SY5Y cells (B) treated with TO901317 and 9-cis retinoic acid for 24 h were incubated with buffer containing 1% Triton X-100 on ice.
Aya Kobayashi (642543), Michinori Matsuo (169167), Shiho Ito (642542), Kazumitsu Ueda (169170), Osamu Sano (642541), Yuji Shimizu (174369), Reiko Kato (372943), Noriyuki Kioka (169174), Yasuhisa Kimura (642544), Kentaro Hanada (207598)   +9 more
core   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, Volume 13, Issue 60, 28 October 2026.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Downregulation of ABCA1 and ABCG1 transporters by simvastatin in cholangiocarcinoma cells

Oncology Letters, 2019
Disturbances in cholesterol homeostasis of the bile duct epithelium, including transport interruption and the hyperaccumulation of intracellular cholesterol can lead to the initiation and progression of cholangiocarcinoma (CCA). Statins, which are lipid-lowering drugs, have been previously documented to exhibit anti-cancer properties.
Seeree, Pattaya, Janvilisri, Tavan, Kangsamaksin, Thaned, Tohtong, Rutaiwan, Kumkate, Supeecha   +4 more
openaire   +3 more sources

Effect of internal deletion or point mutations of apoA-I bound to rHDL particles on ABCG1-mediated cholesterol efflux from HEK293 cells transfected with an ABCG1-expressing plasmid.

, 2013
(A, B) HEK293 cells were transfected with empty vector (mock) or with ABCG1-expressing plasmid, labeled with [14C]cholesterol for 24 h and then incubated with rHDL containing WT or mutants apoA-I forms, at various concentrations (A) or 1 µM of apoA-I (B),
Georgios Daniil (427933), Vassilis I. Zannis (340659), Angeliki Chroni (340655)   +2 more
core   +1 more source

GLP‐1R agonist semaglutide protects human forebrain organoids from cholesterol‐induced neurotoxicity

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Dysregulated cholesterol metabolism represents a critical metabolic stressor in the central nervous system, contributing to neuronal injury across multiple neurological conditions, including Alzheimer's disease (AD). While glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show neuroprotective potential, their capacity to directly
Feifei Yu, Jiani Xu, Yibo Hou, Honghui Zheng, Lingyi Guo, Davit Khutsishvili, Cheng Hai, Wenxin Xu, Bailing Chen, Zitian Wang, Shaohua Ma   +10 more
wiley   +1 more source

Suppression of ABCG1 and ABCG4 by siRNA.

, 2016
(A) SH-SY5Y cells were transfected with siRNA against ABCG1, ABCG4, or scrambled siRNA (control), and allowed to differentiate for 3 days. After 16-h incubation with or without TO901317 (TO) and 9-cis retinoic acid (RA), cells were collected and ABCG1 ...
Aya Kobayashi (642543), Michinori Matsuo (169167), Makoto Michikawa (2795365), Kazumitsu Ueda (169170), Osamu Sano (642541), Maki Tsujita (2795362), Yuji Shimizu (174369), Reiko Kato (372943), Noriyuki Kioka (169174), Alan T. Remaley (77852)   +9 more
core   +1 more source

Additional file 2 of ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease

, 2021
Additional file 2: Fig. S1. Proportional diagram of the structure of ABCA1 (NM_005502.4) (A) and ABCG1 (NM_207174.1) (A) genes and loci selected for DNA methylation analysis. The line represents the gene (left to right: 5′–3′). Solid rectangles represent
Valery P. Puzyrev (11763013), Sofya N. Pchelina (5219150), Irina A. Pobozheva (11762992), Olga D. Belyaeva (11763001), Alexandra A. Panteleeva (11762989), Maria S. Nazarenko (11763010), Valentina V. Miroshnikova (11762986), Natalia D. Razgildina (11762995), Elena I. Baranova (11763007), Ekaterina A. Polyakova (9956813), Anton V. Markov (11762998), Olga A. Berkovich (11763004)   +11 more
core   +1 more source