Results 91 to 100 of about 11,132 (198)

MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells[S]

Journal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1) plays crucial roles at multiple stages of atherosclerosis. We hypothesized that MCP-1 might impair the reverse cholesterol transport (RCT) capacity of HepG2 cells by decreasing the cell-surface protein ...
Can-Xia Huang, Yu-Ling Zhang, Jing-Feng Wang, Jie-Yu Jiang, Jin-Lan Bao   +4 more
doaj   +1 more source

[Retracted] ABCG1 as a potential oncogene in lung cancer

Experimental and Therapeutic Medicine
[This retracts the article DOI: 10.3892/etm.2017.4393.].
Tian, Chunyan, Huang, Di, Yu, Yanli, Zhang, Jihong, Fang, Qingxin, Xie, Chao   +5 more
openaire   +2 more sources

ABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophages

, 2009
Objectives: The uptake of oxidized LDL (oxLDL) by macrophages is a key initial event in atherogenesis, and the removal of oxidized lipids from artery wall via reverse cholesterol transport is considered antiatherogenic.
Xu, M, Wong, Y, Guo, R, Zhou, H, Tan, KCB, Shiu, SWM, Mingzhi Xu, Kathryn C.B. Tan, Sammy W.M. Shiu, Huali Zhou, Ying Wong, Renyong Guo   +11 more
core   +1 more source

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL

Journal of Lipid Research, 2008
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet, Tamara A. Pagler, Nan Wang, Takafumi Senokuchi, May Brundert, Hongna Li, Franz Rinninger, Alan R. Tall   +7 more
doaj   +1 more source

Ex Vivo Characterization of Peritoneal Macrophages from Novel ABCA1-LSL and ABCG1-LSL Mice for Macrophage-Specific ABC-Transporter Overexpression

Biology
We aimed to characterize peritoneal macrophages from two novel mouse models that enable macrophage-specific overexpression of ABCA1 and ABCG1 via Cre recombinase.
Jing Echesabal-Chen, Lawrence Fernando, Ally Brawner, Achala Pokhrel, Kun Huang, Rhonda Reigers Powell, Terri Bruce, Jan Guz, Fu-Lei Tang, Alexander Awgulewitsch, Alexis Stamatikos   +10 more
doaj   +1 more source

Functional interaction between ABCG4 and ABCG1.

, 2016
(A) To test the functional interaction between ABCG proteins, the wild type ABCG1 (G1, upper panels) or the wild type ABCG4 (G4, lower panels) was co-expressed with inactive mutant variants of the studied ABCG proteins (G1KM, G4KM, or G2KM) as indicated ...
László Homolya (538824), Zoltán Hegyi (3166800)   +1 more
core   +1 more source

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

Journal of Lipid Research, 2010
Surfactant accumulates in alveolar macrophages of granulocyte-macrophage colony-stimulating factor (GM-CSF) knockout (KO) mice and pulmonary alveolar proteinosis (PAP) patients with a functional loss of GM-CSF resulting from neutralizing anti–GM-CSF ...
Anna D. Baker, Anagha Malur, Barbara P. Barna, Shobha Ghosh, Mani S. Kavuru, Achut G. Malur, Mary Jane Thomassen   +6 more
doaj   +1 more source

Homodimer formation of ABCG4, ABCG1 and ABCG2.

, 2016
(A) We have generated specific antibodies against ABCG1 (αG1) and ABCG4 (αG4). The specificity of the applied antibodies was confirmed by Western Blot technique performed with 40 μg of whole cell lysates from HEK cells expressing ABCG1 (G1), ABCG2 (G2 ...
László Homolya (538824), Zoltán Hegyi (3166800)   +1 more
core   +1 more source

Small Discoidal Pre-beta1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

, 2009
: The aim of this study was to correlate the lipid content and size of discoidal reconstituted HDL particles with their ability to promote cellular cholesterol efflux. Homogeneous discoidal rHDL particles containing apoA-I and POPC, with diameters of 7.8,
BERNINI, Franco, CALABRESI L., JESSUP W., FRANCESCHINI G., FAVARI, Elda, ADORNI, Maria Pia, SIMONELLI S.   +6 more
core   +2 more sources

Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

Frontiers in Pharmacology
Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered.
Yao Chen, Houshun Fang, Huiying Sun, Xiaoyu Wu, Yan Xu, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Hui Li, Hui Li   +9 more
doaj   +1 more source