Results 91 to 100 of about 15,107 (221)

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Adipose ABCG1: A potential therapeutic target in obesity? [PDF]

Adipocyte, 2015
The importance of ATP-Binding Cassette G1 (ABCG1) transporter in obesity was recently brought to light by recent findings uncovering its key role in adipogenesis with physiopathological consequences in human obesity. Thus, silencing of ABCG1 expression using an RNAi approach allows inhibition of adipocyte differentiation and maturation leading to ...
Frisdal, Eric, Le Goff, Wilfried
openaire   +2 more sources

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor [PDF]

, 2017
Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be realized ...
Beli, Eleni, Busik, Julia V., Grant, Maria B., Hammer, Sandra S., Hazra, Sugata, Kady, Nermin, Levi, Moshe, Lydic, Todd A., Malek, Goldis, Saban, Daniel R., Wang, Qi, Wang, Xiaoxin X., Wood, Kiana   +12 more
core   +2 more sources

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Statin Use Associates With Risk of Type 2 Diabetes via Epigenetic Patterns at ABCG1

Frontiers in Genetics, 2020
Statin is the medication most widely prescribed to reduce plasma cholesterol levels. Yet, how the medication contributes to diabetes risk and impaired glucose metabolism is not clear.
Yuwei Liu, Yuwei Liu, Yu Shen, Tao Guo, Tao Guo, Laurence D. Parnell, Kenneth E. Westerman, Caren E. Smith, Jose M. Ordovas, Jose M. Ordovas, Jose M. Ordovas, Chao-Qiang Lai   +11 more
doaj   +1 more source

From Adipose Tissue to Cardiac Repair: Extracellular Vesicles in Cardiovascular Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Adipose‐derived extracellular vesicles (ADEVs) secreted by adipose tissue have gained increasing attention due to their regenerative and immunomodulatory properties in cardiovascular diseases. They carry proteins, lipids, and nucleic acids that mediate intercellular communication and influence cardiac pathophysiology. In atherosclerosis, ADEVs
Karolina Ignaczak, Pola Ochocka, Karol Sadowski, Weronika Ploch, Dominika Tomkiel, Mariusz Tomaniak, Wioletta Olejarz   +6 more
wiley   +1 more source

Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families [PDF]

, 2016
This file contains Supplementary Table 1.
Anthony G. Comuzzie, David C. Glahn, Harald H. H. Göring, Hemant Kulkarni, Jack W. Kent, Jennifer L. Neary, Joanne E. Curran, John Blangero, Laura Almasy, Manju Mamtani, Melanie A. Carless, Michael C. Mahaney, Ravindranath Duggirala, Satish Kumar, Shelley A. Cole, Thomas D. Dyer   +15 more
core   +6 more sources

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source

Insights Into Remote Ischemic Conditioning miRNA Effects on Brain Endothelial Cells During Ischemia–Reperfusion

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Objective Acute ischemic stroke (AIS) is one of the leading causes of death and disabilities, and as such, it is of utmost importance to identify novel treatment options. Remote ischemic conditioning (RIC) is a promising non‐invasive treatment that is thought to activate the body's own protective mechanisms against damaging ischemia.
Katrine Tang Stenz, Jesper Just, Zenghui Huang, Thomas Ravn Lassen, Kristian Vissing, Xiu‐Jie Wang, Kim Ryun Drasbek   +6 more
wiley   +1 more source

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. [PDF]

, 2016
Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce.
Aho, Vilma, Ala-Korpela, Mika, Porkka-Heiskanen, Tarja   +2 more
core   +2 more sources