SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
Journal of Lipid Research, 2008 This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet +7 more
doaj +1 more source
Determinants of HDL Cholesterol Efflux Capacity after Virgin Olive Oil Ingestion: Interrelationships with Fluidity of HDL Monolayer [PDF]
, 2018 Scope: Cholesterol efflux capacity of HDL (CEC) is inversely associated with cardiovascular risk. HDL composition, fluidity, oxidation, and size are related with CEC.
Castañer, Olga +11 more
core +2 more sources
New aspects of cellular cholesterol regulation on blood glucose control- review and perspective on the impact of statin medications on metabolic health [PDF]
, 2017 Cholesterol is an essential component of cell membranes, and during the past several years, diabetes researchers have found that membrane cholesterol levels in adipocytes, skeletal muscle fibers and pancreatic beta cells influence insulin action and ...
Elmendorf, Jeffrey S., Grice, Brian A.
core +1 more source
Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism
Journal of Lipid Research, 2010 Surfactant accumulates in alveolar macrophages of granulocyte-macrophage colony-stimulating factor (GM-CSF) knockout (KO) mice and pulmonary alveolar proteinosis (PAP) patients with a functional loss of GM-CSF resulting from neutralizing anti–GM-CSF ...
Anna D. Baker +6 more
doaj +1 more source
Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI
Journal of Lipid Research, 2012 To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice.
Ailing Ji +5 more
doaj +1 more source
TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]
, 2019 OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
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Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2 [PDF]
, 2015 Background The nuclear receptor liver X receptor (LXR) exerts transcriptional control over lipid metabolism and inflammatory response in cells of the myeloid lineage, suggesting that LXR may be a potential target in a number of chronic neuroinflammatory ...
McVoy, Julie R Secor +2 more
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LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
Journal of Lipid Research, 2002 Regulation of gene expression of ATP-binding cassette transporter (ABC)A1 and ABCG1 by liver X receptor/retinoid X receptor (LXR/RXR) ligands was investigated in the human intestinal cell line CaCo-2.
Shubha Murthy +3 more
doaj +1 more source
Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. [PDF]
, 2017 Background/objectiveYouth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles.
Davidson, WS +8 more
core +1 more source