ABCG1 regulates pulmonary surfactant metabolism in mice and men[S]
Journal of Lipid Research, 2017 Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are restricted to epithelial type 2 (T2) pneumocytes (also called T2 cells). Clearance of surfactant is
Thomas Q. de Aguiar Vallim +12 more
doaj +1 more source
Synergetic Effect of rHDL and LXR Agonist on Reduction of Atherosclerosis in Mice
Frontiers in Pharmacology, 2020 High-density lipoproteins (HDLs) are unique in that they play an important role in the reverse cholesterol transport process. However, reconstituted HDL (rHDL) infusions have demonstrated limited beneficial effect in clinical practice.
Emily E. Morin +8 more
doaj +1 more source
Down-regulation of ATP-binding cassette transporter G1 expression by unmethylated CpG oligodeoxynucleotides in RAW 264.7 macrophages. [PDF]
Exp Mol Med, 2011 We have investigated the effect of various forms of phosphodiester cytidine-phosphate-guanosine oligodeoxynucleotides (CpG ODNs) on the production of pro-inflammatory cytokines and related genes in RAW 264.7 macrophages. Treatment with the CpG ODNs increased the expression of tumor necrosis factor α (TNF-α), IL-6, and inducible nitric oxide synthase ...
Seo JM, Lee JY, Ji GE, You JC.
europepmc +4 more sources
Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice [PDF]
Circulation Research, 2013 Rationale: Plasma high-density lipoprotein levels are inversely correlated with atherosclerosis. Although it is widely assumed that this is attributable to the ability of high-density lipoprotein to promote cholesterol efflux from macrophage foam cells, direct ...
Westerterp, Marit +15 more
openaire +2 more sources
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux
Journal of Lipid Research, 2009 Among the known mechanisms of reverse cholesterol transport (RCT), ATP binding cassette transporter G1 (ABCG1)-mediated free cholesterol (FC) transport is the most recent and least studied.
Sandhya Sankaranarayanan +7 more
doaj +1 more source
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters
Frontiers in Pharmacology, 2020 Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Tuire Salonurmi +21 more
doaj +1 more source
Journal of Lipid Research, 2007 Although intracellular cholesterol levels are known to influence the proteolysis of β-amyloid precursor protein (APP), the effect of specific genes that regulate cholesterol metabolism on APP processing remains poorly understood.
Gavin H. Tansley +16 more
doaj +1 more source
The binding specificity of OppA determines the selectivity of the oligopeptide ATP-binding cassette transporter [PDF]
, 2021 The purification and functional reconstitution of a five-component oligopeptide ATP-binding cassette transporter with a remarkably wide substrate specificity are described.
Abele, Rupert +3 more
core +2 more sources
Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI
Journal of Lipid Research, 2012 To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice.
Ailing Ji +5 more
doaj +1 more source
Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration
Journal of Lipid Research, 2018 Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their outer segment lipid membranes in a circadian manner, increasing the metabolic burden on the outer
Norimitsu Ban +7 more
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