Results 31 to 40 of about 15,927 (179)

Adaptive laboratory evolution of a genome-reduced Escherichia coli. [PDF]

, 2019
Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be ...
Cho, Byung-Kwan, Cho, Suhyung, Choe, Donghui, Hwang, Soonkyu, Kim, Sun Chang, Lee, Jun Hyoung, Palsson, Bernhard, Sung, Bong Hyun, Yoo, Minseob   +8 more
core   +2 more sources

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

Journal of Lipid Research, 2007
Although intracellular cholesterol levels are known to influence the proteolysis of β-amyloid precursor protein (APP), the effect of specific genes that regulate cholesterol metabolism on APP processing remains poorly understood.
Gavin H. Tansley, Braydon L. Burgess, Matt T. Bryan, Su Yuan, Hirsch-Reinshagen Veronica, Pearce Jonathan, Jeniffer Y. Chan, Wilkinson Anna, Evans Jeanette, Kathryn E. Naus, McIsaac Sean, Bromley Kelley, Song Weihong, Yang Hsui-Chiung, Wang Nan, Ronald B. DeMattos, Cheryl L. Wellington   +16 more
doaj   +1 more source

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI

Journal of Lipid Research, 2012
To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice.
Ailing Ji, Joanne M. Wroblewski, Lei Cai, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration

Journal of Lipid Research, 2018
Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their outer segment lipid membranes in a circadian manner, increasing the metabolic burden on the outer
Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Daniel S. Ory, Rajendra S. Apte   +7 more
doaj   +1 more source

E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro

Acta Pharmaceutica Sinica B, 2016
Liver X receptor (LXR) plays an important role in reverse cholesterol transport (RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists.
Ni Li, Xiao Wang, Peng Liu, Duo Lu, Wei Jiang, Yanni Xu, Shuyi Si   +6 more
doaj   +1 more source

ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages. [PDF]

PLoS ONE, 2014
ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol transporter involved in macrophage sterol homeostasis, reverse cholesterol transport (RCT), and atherosclerosis.
Fang Liu, Wei Wang, Yan Xu, Yu Wang, Lian-Feng Chen, Quan Fang, Xiao-Wei Yan   +6 more
doaj   +1 more source

Decreased functional activity of multidrug resistance protein in primary colorectal cancer [PDF]

, 2015
BACKGROUND The ATP-Binding Cassette (ABC)-transporter MultiDrug Resistance Protein 1 (MDR1) and Multidrug Resistance Related Protein 1 (MRP1) are expressed on the surface of enterocytes, which has led to the belief that these high capacity ...
Baranyai Zsolt, Besznyák István Endre, Dede Kristóf, Jakab Ferenc, Kéri György, Lőrincz András, Mersich Tamás, Micsik Tamás, Peták István, Schwab Richard, Szöllösi Krecsák László, Zaránd Attila   +11 more
core   +2 more sources

Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles

Journal of Pharmaceutical Analysis
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic and medical fields. However, this drug faces a series of challenges when used to treat atherosclerosis caused by hyperhomocysteinemia (HHcy ...
Dayue Liu, Anning Yang, Yulin Li, Zhenxian Li, Peidong You, Hongwen Zhang, Shangkun Quan, Yue Sun, Yaling Zeng, Shengchao Ma, Jiantuan Xiong, Yinju Hao, Guizhong Li, Bin Liu, Huiping Zhang, Yideng Jiang   +15 more
doaj   +1 more source

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Journal of Lipid Research, 2007
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung.
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio   +8 more
doaj   +1 more source

Chlamydial infection from outside to inside [PDF]

, 2019
Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke, Sanders, Niek, Vanrompay, Daisy   +2 more
core   +2 more sources