Results 21 to 30 of about 2,025,163 (218)

Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7

Journal of Lipid Research, 2005
The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.
Michi Hayashi, Sumiko Abe-Dohmae, Mitsuyo Okazaki, Kazumitsu Ueda, Shinji Yokoyama   +4 more
doaj   +1 more source

ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol [PDF]

Journal of Biological Chemistry, 2001
Alpha-tocopherol (alpha-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting alpha-TOH between tissues. Here we show that secretion of alpha-TOH from cultured cells is mediated in part by ABCA1, an ATP-binding cassette protein that transports cellular
J F, Oram, A M, Vaughan, R, Stocker
openaire   +2 more sources

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice[S]

Journal of Lipid Research, 2009
We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice.
Todd Juan, Murielle M. Véniant, Joan Helmering, Philip Babij, Daniel M. Baker, Michael A. Damore, Michael B. Bass, Tibor Gyuris, Mark Chhoa, Chi-Ming Li, Chris Ebeling, Julie Amato, George A. Carlson, David J. Lloyd   +13 more
doaj   +1 more source

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

Journal of Lipid Research, 2015
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and ...
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renée C. LeBoeuf   +4 more
doaj   +1 more source

Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway. [PDF]

J Cell Mol Med
ABSTRACT The regulatory role of bone marrow in systemic metabolic processes remains incompletely characterized. Myeloid‐derived growth factor (MYDGF) is a myeloid cell‐secreted factor with emerging metabolic functions, but its action in diabetes‐associated non‐alcoholic fatty liver disease (DM NAFLD) is undefined.
Chen Z, Meng B, Wang B, Ding Y.
europepmc   +2 more sources

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞

Journal of Lipid Research, 2007
The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse.
Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman   +11 more
doaj   +1 more source

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients

Frontiers in Pharmacology, 2021
Objective: It has been reported that atrial natriuretic peptide (ANP) regulates lipid metabolism by stimulating adipocyte browning, lipolysis, and lipid oxidation, and by impacting the secretion of adipokines.
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song   +5 more
doaj   +1 more source

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. [PDF]

Nat Commun, 2017
VÎ339VÎ ́2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms.
Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, Caruso D, Novelli F, Riganti C, Massaia M.   +9 more
europepmc   +2 more sources

Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys1

Journal of Lipid Research, 2010
Accumulation of cholesterol in arterial macrophages may contribute to diabetes-accelerated atherosclerotic cardiovascular disease. The ATP-binding cassette transporter ABCA1 is a cardioprotective membrane protein that mediates cholesterol export from ...
Chongren Tang, Jenny E. Kanter, Karin E. Bornfeldt, Renee C. Leboeuf, John F. Oram   +4 more
doaj   +1 more source

Activation of ATP-Binding Cassette Transporter A1 Transcription by Chromatin Remodeling Complex [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Objective— Liver X receptor (LXR) regulates the transcription of ATP-binding cassette transporter A1 (ABCA1) by binding to the DR-4 promoter element as a heterodimer with retinoid X receptor (RXR). The role of chromatin remodeling complex in LXR or ABCA1 activation has not been established previously.
Jarkko, Huuskonen, Meeta, Vishnu, Phoebe E, Fielding, Christopher J, Fielding   +3 more
openaire   +2 more sources