Results 31 to 40 of about 12,429 (225)
Activation of ATP-Binding Cassette Transporter A1 Transcription by Chromatin Remodeling Complex [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Liver X receptor (LXR) regulates the transcription of ATP-binding cassette transporter A1 (ABCA1) by binding to the DR-4 promoter element as a heterodimer with retinoid X receptor (RXR). The role of chromatin remodeling complex in LXR or ABCA1 activation has not been established previously.
Jarkko, Huuskonen +3 more
openaire +2 more sources
ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 ATP-binding cassette transporter A1 (ABCA1) is a key protein determining high-density lipoprotein (HDL) function. In 1999, it was discovered by 3 independent groups that mutations in the gene for ABCA1 underlie the molecular defect in the HDL deficiency syndrome Tangier disease.
Miranda, Van Eck, Theo J C, Van Berkel
openaire +2 more sources
Journal of Lipid Research, 2004 Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field +2 more
doaj +1 more source
, 2020 International audienceObjective: Patients with schizophrenia have increased long-term mortality attributable to cardiovascular disease and commonly demonstrate features of mixed dyslipidemia with low HDL-C (high-density lipoprotein cholesterol).
Kontush, Anatol +6 more
core +1 more source
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells
Journal of Lipid Research, 2008 ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor HDL and maintains cellular lipid homeostasis.
Vijay Paul +4 more
doaj +1 more source
Hydrogen Sulfide Up-Regulates the Expression of ATP-Binding Cassette Transporter A1 via Promoting Nuclear Translocation of PPARα. [PDF]
Int J Mol Sci, 2016 ATP binding cassette transporter A1 (ABCA1) plays a key role in atherogenesis. Hydrogen sulfide (H2S), a gasotransmitter, has been reported to play an anti-atherosclerotic role. However, the underlying mechanisms are largely unknown.
Li D +6 more
europepmc +2 more sources
ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids [PDF]
The Journal of Nutritional Biochemistry, 2012 Ample evidence indicates that dietary fatty acids alter the plasma levels of high-density lipoprotein cholesterol (HDL-C). However, the mechanisms underlying the effects of fatty acids still remain elusive. Recent advances in our understanding of ATP-binding cassette transporter A1 (ABCA1) function and regulation have provided a valuable insight into ...
Jiyoung, Lee, Youngki, Park, Sung I, Koo
openaire +2 more sources
Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells
Journal of Lipid Research, 2003 Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of
Soazig Le Lay +5 more
doaj +1 more source
New Strategies to Promote Macrophage Cholesterol Efflux
Frontiers in Cardiovascular Medicine, 2021 The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2011 .: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation.
Takashi Maejima +6 more
doaj +1 more source