Results 31 to 40 of about 26,719 (220)

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice[S]

Journal of Lipid Research, 2009
We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice.
Todd Juan, Murielle M. Véniant, Joan Helmering, Philip Babij, Daniel M. Baker, Michael A. Damore, Michael B. Bass, Tibor Gyuris, Mark Chhoa, Chi-Ming Li, Chris Ebeling, Julie Amato, George A. Carlson, David J. Lloyd   +13 more
doaj   +1 more source

Activation of ATP-Binding Cassette Transporter A1 Transcription by Chromatin Remodeling Complex [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Objective— Liver X receptor (LXR) regulates the transcription of ATP-binding cassette transporter A1 (ABCA1) by binding to the DR-4 promoter element as a heterodimer with retinoid X receptor (RXR). The role of chromatin remodeling complex in LXR or ABCA1 activation has not been established previously.
Jarkko, Huuskonen, Meeta, Vishnu, Phoebe E, Fielding, Christopher J, Fielding   +3 more
openaire   +2 more sources

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

Journal of Lipid Research, 2015
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and ...
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renée C. LeBoeuf   +4 more
doaj   +1 more source

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞

Journal of Lipid Research, 2007
The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse.
Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman   +11 more
doaj   +1 more source

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients

Frontiers in Pharmacology, 2021
Objective: It has been reported that atrial natriuretic peptide (ANP) regulates lipid metabolism by stimulating adipocyte browning, lipolysis, and lipid oxidation, and by impacting the secretion of adipokines.
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song   +5 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Increased ABCA1 (ATP-Binding Cassette Transporter A1)-Specific Cholesterol Efflux Capacity in Schizophrenia [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Objective: Patients with schizophrenia have increased long-term mortality attributable to cardiovascular disease and commonly demonstrate features of mixed dyslipidemia with low HDL-C (high-density lipoprotein cholesterol). The removal of cholesterol from cells by HDL via specific ATP-binding cholesterol transporters is a major
Luquain-Costaz, Céline, Kockx, Maaike, Anastasius, Malcolm, Chow, Vincent, Kontush, Anatol, Jessup, Wendy, Kritharides, Leonard   +6 more
openaire   +4 more sources

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids [PDF]

The Journal of Nutritional Biochemistry, 2012
Ample evidence indicates that dietary fatty acids alter the plasma levels of high-density lipoprotein cholesterol (HDL-C). However, the mechanisms underlying the effects of fatty acids still remain elusive. Recent advances in our understanding of ATP-binding cassette transporter A1 (ABCA1) function and regulation have provided a valuable insight into ...
Jiyoung, Lee, Youngki, Park, Sung I, Koo
openaire   +2 more sources