Results 11 to 20 of about 11,658 (183)
Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians [PDF]
Journal of Diabetes Research, 2015 Background. Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors.
Polin Haghvirdizadeh +6 more
doaj +2 more sources
Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1). [PDF]
Molecules, 2011 The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport.
Xu Y, Xu Y, Bao Y, Hong B, Si S.
europepmc +5 more sources
Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. [PDF]
J Biol Chem, 2011 ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoproteins. Using a mouse macrophage cell line, this report studied the impact of low-density lipoproteins (LDL) on ABCA1 expression and the signaling pathway responsible for lipoprotein-induced ABCA1 expression ...
Chen X +5 more
europepmc +4 more sources
ABCA1 is an extracellular phospholipid translocase
Nature Communications, 2022 ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest +6 more
doaj +1 more source
Cardiovascular Therapeutics, 2022 Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu +3 more
doaj +1 more source
Journal of Lipid Research, 2006 Serum amyloid A (SAA) is an amphiphilic helical protein that is found associated with plasma HDL in various pathological conditions, such as acute or chronic inflammation. Cellular lipid release and generation of HDL by this protein were investigated, in
Sumiko Abe-Dohmae +10 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 Abnormal amyloid beta (Aβ) clearance is a distinctive pathological mechanism for Alzheimer’s disease (AD). ATP-binding cassette transporter A1 (ABCA1), which mediates the lipidation of apolipoprotein E, plays a critical role in Aβ clearance.
Dongmei Wu, Yang Hu, Min Song, Gongbo Li
doaj +1 more source
Journal of Lipid Research, 2006 Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj +1 more source
Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
Journal of Lipid Research, 2005 The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.
Michi Hayashi +4 more
doaj +1 more source
ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol [PDF]
Journal of Biological Chemistry, 2001 Alpha-tocopherol (alpha-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting alpha-TOH between tissues. Here we show that secretion of alpha-TOH from cultured cells is mediated in part by ABCA1, an ATP-binding cassette protein that transports cellular
J F, Oram, A M, Vaughan, R, Stocker
openaire +2 more sources