Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1). [PDF]
Molecules, 2011 The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport.
Xu Y, Xu Y, Bao Y, Hong B, Si S.
europepmc +6 more sources
Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter [PDF]
Journal of Biological Chemistry, 2004 In a previous characterization of the ABCA subfamily of the ATP-binding cassette (ABC) transporters, we identified potential protein kinase 2 (CK2) phosphorylation sites, which are conserved in eukaryotic and prokaryotic members of the ABCA transporters.
Roosbeek, Stein +13 more
openaire +5 more sources
ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses [PDF]
Lipids in Health and Disease, 2011 Objective The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)]
Degiannis Dimitrios +8 more
doaj +3 more sources
ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1. [PDF]
Int J Mol Sci, 2019 Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal.
Lee YR +6 more
europepmc +2 more sources
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study
Cuffe H +9 more
europepmc +2 more sources
The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. [PDF]
Nat Commun, 2017 VÎ339VÎ ́2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms.
Castella B +9 more
europepmc +2 more sources
ABCA1 is an extracellular phospholipid translocase
Nature Communications, 2022 ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest +6 more
doaj +1 more source
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous ...
Radosveta, Koldamova +2 more
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Cardiovascular Therapeutics, 2022 Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu +3 more
doaj +1 more source
Journal of Lipid Research, 2006 Serum amyloid A (SAA) is an amphiphilic helical protein that is found associated with plasma HDL in various pathological conditions, such as acute or chronic inflammation. Cellular lipid release and generation of HDL by this protein were investigated, in
Sumiko Abe-Dohmae +10 more
doaj +1 more source