Results 51 to 60 of about 1,999,074 (184)

Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB [PDF]

, 2005
Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core  

Structure of WbdD : a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a [PDF]

, 2012
The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan biosynthesis and export by the ATP-binding cassette transporter-dependent pathway.
James H. Naismith, Gregor Hagelueken, Bradley R. Clarke, Hagelueken, Gregor, Huang, Hexian, Chris Whitfield, Clarke, Bradley R., Whitfield, Chris, Tomas Lebl, Lebl, Tomas, Naismith, James H., Hexian Huang, Lebl, Tomas; id_orcid   +12 more
core   +1 more source

Role of ABCG1 and other ABCG family members in lipid metabolism

Journal of Lipid Research, 2001
The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes.
Gerd Schmitz, Thomas Langmann, Susanne Heimerl   +2 more
doaj   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Fingerprint of the mitochondrial ABC transporter Mdl1p from Saccharomyces cerevisiae [PDF]

, 2006
The multidrug resistance like protein 1 (Mdl1p) belongs to the class of ATP binding cassette (ABC) transporters which comprise a large family of membrane proteins utilising ATP hydrolysis to drive up-hill transport of a wide variety of solutes across ...
Hofacker, Matthias
core  

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

, 2013
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress.
Gileadi, O., Li, Q., Yang, J., von Delft, F., Bullock, A.N., Barr, A. J., Ross, J., Sansom, M. S. P., Carpenter, E. P., Carpenter, E.P., Kim, J-I., Barr, A.J., Burgess-Brown, N.A., Shintre, C. A., Berridge, G., Marsden, B., Stansfeld, P.J., Sansom, M.S.P., Burgess-Brown, N. A., Bountra, C., Shrestha, L., Shintre, C.A., Goubin, S., Bullock, A. N., Pike, A. C. W., Kim, J.I., Pike, A.C.W., Edwards, A.M., Stansfeld, Phillip J., Edwards, A. M., Marsden, B. D.   +30 more
core   +1 more source

Identification of Dehydroxytrichostatin A as a Novel Up-Regulator of the ATP-Binding Cassette Transporter A1 (ABCA1) [PDF]

Molecules, 2011
The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport.
Xu, Yang, Xu, Yanni, Bao, Yi, Hong, Bin, Si, Shuyi   +4 more
openaire   +3 more sources

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Mechanistic insights into ATP hydrolysis by the ABC transporter TAP [PDF]

, 2004
The transporter associated with antigen processing (TAP) plays a pivotal role in the adaptive immune response against virus-infected or malignantly transformed cells.
Chen, Min
core  

The implication of adipocyte ATP-binding cassette A1 and G1 transporters in metabolic complications of obesity. [PDF]

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019
Obesity is characterised by imbalance in lipid metabolism manifested by high concentrations of circulating triacylglycerols and total cholesterol as well as low high-density lipoprotein (HDL) levels. Abnormalities related to these lipids lead to metabolic complications such as type 2 diabetes, arterial hypertension and cardiovascular disease.
Barbara Choromańska, Piotr Myśliwiec, Hady Razak Hady, Jacek Dadan, Hanna Myśliwiec, Tomasz Bonda, Adrian Chabowski, Agnieszka Mikłosz   +7 more
openaire   +2 more sources