Results 11 to 20 of about 378,964 (291)

Cholesterol Efflux and Reverse Cholesterol Transport [PDF]

, 2014
Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda, Chroni, Angelika, Tietge, Uwe J. F, ZANOTTI, Ilaria, Escolà Gil, Joan Carles, BERNINI, Franco   +5 more
openaire   +7 more sources

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang, Anela Tosevska, Elke H. Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl‐Heinz Wagner, Verena M. Dirsch, Atanas G. Atanasov   +9 more
doaj   +2 more sources

Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages [PDF]

Molecules, 2014
Foam cells formation as a result of the uncontrolled cytophagy of modified cholesterol by macrophages plays a key role in the occurrence and development of atherosclerosis. Sesamin is an active constituent of Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated the effects of sesamin on foam
Liu, Nan, Wu, Chongming, Sun, Lizhong, Zheng, Jun, Guo, Peng   +4 more
openaire   +4 more sources

Cholesterol Efflux Capacity

Journal of the American College of Cardiology, 2016
Apolipoprotein B (apoB)-depleted sera of healthy subjects (control, n = 27) and patients with age-related macular degeneration (AMD, n = 29) were examined for (A) their ability to promote [3H]-cholesterol efflux from macrophages. [3H]-cholesterol-labeled
Winfried März, Andreas Ritsch
openaire   +2 more sources

The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis [PDF]

, 2012
PhDOligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies suggest can protect against cardiovascular disease. To explore this further a double-blind randomised controlled crossover trial, EPICURE (Evaluation of high ...
Rull, Gurvinder Kaur
core   +4 more sources

Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis [PDF]

, 2013
Disruption of cholesterol homeostasis in the central nervous system (CNS) has been associated with neurological, neurodegenerative, and neurodevelopmental disorders.
Xiaolu Zhang (433873), Lucio G. Costa (7923131), Marina Guizzetti (5701034), Handojo Kusumo (5218109), Jing Chen (4762)   +4 more
core   +7 more sources

Cholesterol efflux in the transplant patient [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2018
Purpose of review Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients.
Sangita, Sudharshan, Ali, Javaheri
openaire   +2 more sources

Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.

Journal of Lipid Research, 1995
The effect of oxysterols on efflux of cholesterol from mouse L-cell fibroblasts, rat Fu5AH hepatoma cells, J774 macrophages, and human EA.hy 926 endothelial cells was studied.
E P Kilsdonk, D W Morel, W J Johnson, G H Rothblat   +3 more
doaj   +1 more source

Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Journal of Cardiovascular Development and Disease, 2023
Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC ...
Olanrewaju Oladosu, Ikechukwu C. Esobi, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +4 more
doaj   +1 more source

Cholesterol Efflux and Atheroprotection [PDF]

Circulation, 2012
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatory properties, nitric oxide–promoting activity, and ability to transport proteins with their own intrinsic biological activities.1 HDL particles are critical
Robert S, Rosenson, H Bryan, Brewer, W Sean, Davidson, Zahi A, Fayad, Valentin, Fuster, James, Goldstein, Marc, Hellerstein, Xian-Cheng, Jiang, Michael C, Phillips, Daniel J, Rader, Alan T, Remaley, George H, Rothblat, Alan R, Tall, Laurent, Yvan-Charvet   +13 more
openaire   +2 more sources