Cholesterol Efflux and Reverse Cholesterol Transport [PDF]
, 2014 Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda +5 more
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A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol
Journal of Lipid Research, 2011 Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [3H]cholesterol and measuring release of the labeled ...
Michael Phillips +2 more
exaly +3 more sources
Cholesterol efflux pathways, inflammation, and atherosclerosis [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not showing any benefit of plasma HDL-cholesterol raising ...
Anouk G. Groenen +3 more
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Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1s⃞ [PDF]
Journal of Lipid Research, 2007 ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver.
Osamu Sano +7 more
doaj +3 more sources
Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang +9 more
doaj +2 more sources
Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages [PDF]
Molecules, 2014 Foam cells formation as a result of the uncontrolled cytophagy of modified cholesterol by macrophages plays a key role in the occurrence and development of atherosclerosis. Sesamin is an active constituent of Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated the effects of sesamin on foam
Nan Liu +4 more
openaire +5 more sources
Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess cholesterol.
Alice Dupont Juhl, Daniel Wüstner
doaj +3 more sources
Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion [PDF]
Journal of Lipid Research, 1997 It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
doaj +2 more sources
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages [PDF]
FEBS Open Bio, 2021 Apolipoprotein M (ApoM) exhibits various anti‐atherosclerotic functions as a component of high‐density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR‐BI) is a classic HDL receptor that mediates selective cholesterol uptake and ...
Shuang Yao +6 more
doaj +2 more sources
E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1 [PDF]
The Journal of Clinical InvestigationAtherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA-Seq, we identified Listerin E3 ubiquitin protein ligase 1 (Listerin) as a ...
Lei Cao +17 more
doaj +2 more sources