Results 31 to 40 of about 50,002 (295)

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]

, 2011
Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Mei-Ju Hsu, Frazer J. Rixon, Petermann, P., Rixon Frazer J., Rahn, E., Hsu Mei-Ju, Knebel-Mörsdorf, D., Geraghty, R.J., Dagmar Knebel-Mörsdorf, Rahn Elena, Philipp Petermann, Knebel-Mörsdorf Dagmar, Elena Rahn, Frazer J Rixon, Hsu, M.-J., Rixon, F.J., Petermann Philipp   +16 more
core   +1 more source

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Journal of Lipid Research, 2015
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton   +9 more
doaj   +1 more source

Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy [PDF]

Journal of Diabetes Research, 2021
Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells,
Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Qiyun Wang   +3 more
openaire   +3 more sources

Importance of macrophage cholesterol content on the flux of cholesterol mass

Journal of Lipid Research, 2010
Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan, Margarita de la Llera-Moya, Denise Drazul-Schrader, Bela F. Asztalos, Ginny L. Weibel, George H. Rothblat   +5 more
doaj   +1 more source

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages

Journal of Lipid Research, 2019
Sphingolipid and cholesterol metabolism are closely associated at the structural, biochemical, and functional levels. Although HDL-associated sphingosine-1-phosphate (S1P) contributes to several HDL functions, and S1P signaling regulates glucose and ...
Mithila Vaidya, Julian A. Jentsch, Susann Peters, Petra Keul, Sarah Weske, Markus H. Gräler, Emil Mladenov, George Iliakis, Gerd Heusch, Bodo Levkau   +9 more
doaj   +1 more source

Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography

Lipids in Health and Disease, 2009
Background Studies in patients with low HDL have suggested that impaired cellular cholesterol efflux is a heritable phenotype increasing atherosclerosis risk.
Kremer Werner, Huber Fritz, Lieb Wolfgang, Mayer Björn, Belz Stefanie, Aherrarhou Zouhair, Jansen Henning, Linsel-Nitschke Patrick, Kalbitzer Hans-Robert, Erdmann Jeanette, Schunkert Heribert   +10 more
doaj   +1 more source

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL

Journal of Lipid Research, 2008
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet, Tamara A. Pagler, Nan Wang, Takafumi Senokuchi, May Brundert, Hongna Li, Franz Rinninger, Alan R. Tall   +7 more
doaj   +1 more source

Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

Annals of Medicine, 2022
Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver.
Marco Magnoni, Daniele Andreini, Angela Pirillo, Patrizia Uboldi, Roberto Latini, Alberico L. Catapano, Aldo P. Maggioni, Giuseppe D. Norata   +7 more
doaj   +1 more source

Cholesterol efflux from 3D cultured hepatic constructs.

, 2022
Cholesterol efflux supported by lipoproteins is a key property of hepatocytes. To assess efflux, PHH were cultured in 3D and radiolabeled with 3H-cholesterol for 24 hours after 5 and 7 days post culture.
Thomas J. DePalma (11978859), Nathaniel Hauser (11978865), Elaheh Rahbar (4476481), John S. Parks (11807758), L. Madison Kirk (11978844), Antonio C. Renaldo (11978856), Chia-Chi Chuang Key (11978868), Aleksander Skardal (6472949), Kelli N. Simms (11978862), Carl D. Langefeld (9321905), Charlotte Mae K. Waits (11978847), Beverly Dosso (11978853), Allison K. Meyers (11821457), Susan Sergeant (134416), Alexander C. Bashore (11978850), Charles E. McCall (7486847)   +15 more
core   +1 more source

Cellular Cholesterol Efflux Mediated by Cyclodextrins [PDF]

Journal of Biological Chemistry, 1995
In this study, we compared cholesterol efflux mediated by either high density lipoproteins (HDL3) or beta-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their hydrophobic core. beta-Cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, and methyl-beta-cyclodextrin at 10 mM induced the release of 50-90% of L-cell [3H]cholesterol ...
E P, Kilsdonk, P G, Yancey, G W, Stoudt, F W, Bangerter, W J, Johnson, M C, Phillips, G H, Rothblat   +6 more
openaire   +3 more sources