Results 31 to 40 of about 80,716 (308)

Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography

Lipids in Health and Disease, 2009
Background Studies in patients with low HDL have suggested that impaired cellular cholesterol efflux is a heritable phenotype increasing atherosclerosis risk.
Kremer Werner, Huber Fritz, Lieb Wolfgang, Mayer Björn, Belz Stefanie, Aherrarhou Zouhair, Jansen Henning, Linsel-Nitschke Patrick, Kalbitzer Hans-Robert, Erdmann Jeanette, Schunkert Heribert   +10 more
doaj   +1 more source

Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

Annals of Medicine, 2022
Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver.
Marco Magnoni, Daniele Andreini, Angela Pirillo, Patrizia Uboldi, Roberto Latini, Alberico L. Catapano, Aldo P. Maggioni, Giuseppe D. Norata   +7 more
doaj   +1 more source

Cholesterol acquisition by Mycobacterium tuberculosis [PDF]

, 2015
In this issue of Virulence, Ramon-Garcia et al. demonstrate the requirement of a mycobacterial efflux pump during growth on cholesterol.
Larrouy-Maumus, GJ
core   +1 more source

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL

Journal of Lipid Research, 2008
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet, Tamara A. Pagler, Nan Wang, Takafumi Senokuchi, May Brundert, Hongna Li, Franz Rinninger, Alan R. Tall   +7 more
doaj   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Cellular Cholesterol Efflux Mediated by Cyclodextrins [PDF]

Journal of Biological Chemistry, 1995
In this study, we compared cholesterol efflux mediated by either high density lipoproteins (HDL3) or beta-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their hydrophobic core. beta-Cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, and methyl-beta-cyclodextrin at 10 mM induced the release of 50-90% of L-cell [3H]cholesterol ...
E P, Kilsdonk, P G, Yancey, G W, Stoudt, F W, Bangerter, W J, Johnson, M C, Phillips, G H, Rothblat   +6 more
openaire   +3 more sources

Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E

Journal of Lipid Research, 1999
In these studies, we have utilized a J774 macrophage model in order to compare phospholipid and cholesterol efflux kinetics in macrophage cells that do not express endogenous apoE to cells transfected to express physiologic levels of human apoE.
Chen-Yi Lin, Hongwei Duan, Theodore Mazzone   +2 more
doaj   +1 more source

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

Journal of Lipid Research, 2017
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mice ...
Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R. Lagor, Hannah J. Szapary, Junichiro Tohyama, John S. Millar, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Daniel J. Rader   +10 more
doaj   +1 more source

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]

, 2019
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G, He, Cuiwen, Heizer, Patrick J, Hu, Xuchen, Jiang, Haibo, Jung, Rachel S, Tontonoz, Peter, Tu, Yiping, Weston, Thomas A, Wohlschlegel, James A, Young, Brian D, Young, Stephen G   +11 more
core   +3 more sources

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]

, 2018
Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty, Hui, Hussain, Lin, Mahley, Pepe, Roselaar   +6 more
core   +2 more sources