TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells [PDF]
, 2018 Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation.
Bartholomew, Christopher +4 more
core +1 more source
Cholesterol Efflux and Atheroprotection [PDF]
Circulation, 2012 High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatory properties, nitric oxide–promoting activity, and ability to transport proteins with their own intrinsic biological activities.1 HDL particles are critical
Robert S, Rosenson +13 more
openaire +2 more sources
Importance of macrophage cholesterol content on the flux of cholesterol mass
Journal of Lipid Research, 2010 Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan +5 more
doaj +1 more source
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]
, 2016 Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping +7 more
core +2 more sources
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
core +2 more sources
PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux [PDF]
The Journal of Neuroscience, 2019 The absence of functional peripheral myelin protein 22 (PMP22) is associated with shortened lifespan in rodents and severe peripheral nerve myelin abnormalities in several species including humans. Schwann cells and nerves from PMP22 knock-out (KO) mice show deranged cholesterol distribution and aberrant lipid raft morphology, supporting an ...
Ye Zhou +10 more
openaire +2 more sources
Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages
Journal of Lipid Research, 2019 Sphingolipid and cholesterol metabolism are closely associated at the structural, biochemical, and functional levels. Although HDL-associated sphingosine-1-phosphate (S1P) contributes to several HDL functions, and S1P signaling regulates glucose and ...
Mithila Vaidya +9 more
doaj +1 more source
The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64) in BRIN-BD11 insulinoma cells [PDF]
, 2016 No abstract ...
Borges Pinto, Joana, Graham, Annette
core +4 more sources
α-Synuclein Regulates Neuronal Cholesterol Efflux [PDF]
Molecules, 2017 α-Synuclein is a neuronal protein that is at the center of focus in understanding the etiology of a group of neurodegenerative diseases called α-synucleinopathies, which includes Parkinson’s disease (PD). Despite much research, the exact physiological function of α-synuclein is still unclear.
Hsiao, JHT +3 more
openaire +4 more sources
Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats [PDF]
, 2013 Peer reviewedPublisher ...
A Venkateswaran +72 more
core +12 more sources