Results 21 to 30 of about 50,237 (296)

Cholesterol Efflux Capacity [PDF]

Journal of the American College of Cardiology, 2016
Apolipoprotein B (apoB)-depleted sera of healthy subjects (control, n = 27) and patients with age-related macular degeneration (AMD, n = 29) were examined for (A) their ability to promote [3H]-cholesterol efflux from macrophages. [3H]-cholesterol-labeled
Winfried März, Andreas Ritsch
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Cholesterol Efflux Assay [PDF]

Journal of Visualized Experiments, 2012
Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Hann, Low, Anh, Hoang, Dmitri, Sviridov
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Cholesterol efflux [PDF]

Arteriosclerosis thrombosis and vascular biology, 2012
Monocytosis and neutrophilia are well-established risk factors for atherosclerosis and seem to play a causative role in lesion development. Studies in mice with defects in cholesterol efflux pathways have identified novel roles for the ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, and apolipoprotein E in suppressing ...
Tall, Alan R, Yvan-Charvet, Laurent, Westerterp, Marit, Murphy, Andrew J   +3 more
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Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]

PLoS ONE, 2016
Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi   +6 more
doaj   +1 more source

Targeted cholesterol efflux [PDF]

Cell Cycle, 2013
In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Fang, Longhou, Miller, Yury I
openaire   +2 more sources

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]

QJM: An International Journal of Medicine, 2005
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi, H, Mu, X, Wang, Q, Yao, C, Chen   +4 more
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Cholesterol efflux from 3D cultured hepatic constructs. [PDF]

, 2022
Cholesterol efflux supported by lipoproteins is a key property of hepatocytes. To assess efflux, PHH were cultured in 3D and radiolabeled with 3H-cholesterol for 24 hours after 5 and 7 days post culture.
Thomas J. DePalma (11978859), Nathaniel Hauser (11978865), Elaheh Rahbar (4476481), John S. Parks (11807758), L. Madison Kirk (11978844), Antonio C. Renaldo (11978856), Chia-Chi Chuang Key (11978868), Aleksander Skardal (6472949), Kelli N. Simms (11978862), Carl D. Langefeld (9321905), Charlotte Mae K. Waits (11978847), Beverly Dosso (11978853), Allison K. Meyers (11821457), Susan Sergeant (134416), Alexander C. Bashore (11978850), Charles E. McCall (7486847)   +15 more
core   +1 more source

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple‐Cell 2D Atherosclerosis Model [PDF]

, 2022
Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood vessels and carotid intima thickening.
Martín Plágaro, César Augusto, Asier Benito‐Vicente, Iraide Alloza, Martín, César, Alloza Moral, Iraide, Koen Vandenbroeck, Vandenbroeck, Koen, Izortze Santin, Benito-Vicente, Asier, Galicia García, Unai, César Martín, Shifa Jebari‐Benslaiman, Santin, Izortze, Ostolaza, Helena, Unai Galicia‐Garcia, Larrea Sebal, Asier, Kepa B. Uribe, Belloso Uribe, Kepa, Benito Vicente, Asier, Santín Gómez, Izortze, Galicia-García, Unai, Ostolaza Echabe, Elena Amaya, Asier Larrea‐Sebal, Uribe, Kepa B., Larrea, Asier, Helena Ostolaza, Alloza, Iraide, Jebari Benslaiman, Shifa, Jebari-Benslaiman, Shifa   +28 more
core   +1 more source

Cholesterol efflux in the transplant patient [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2018
Purpose of review Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients.
Sangita, Sudharshan, Ali, Javaheri
openaire   +2 more sources