Results 21 to 30 of about 50,002 (295)

Cholesterol efflux in the transplant patient [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2018
Purpose of review Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients.
Sangita, Sudharshan, Ali, Javaheri
openaire   +2 more sources

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia. [PDF]

, 2020
Maternal physiological (MPH) or supraphysiological hypercholesterolaemia (MSPH) occurs during pregnancy. Cholesterol trafficking from maternal to foetal circulation requires the uptake of maternal LDL and HDL by syncytiotrophoblast and cholesterol efflux
Kallol, Sampada, Fuenzalida, Bárbara, Leiva, Andrea, Cantin, Claudette, Gutierrez, Jaime, Carvajal, Lorena, Albrecht, Christiane, Contreras-Duarte, Susana, Pastén, Valentina   +8 more
core   +1 more source

Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.

Journal of Lipid Research, 1995
The effect of oxysterols on efflux of cholesterol from mouse L-cell fibroblasts, rat Fu5AH hepatoma cells, J774 macrophages, and human EA.hy 926 endothelial cells was studied.
E P Kilsdonk, D W Morel, W J Johnson, G H Rothblat   +3 more
doaj   +1 more source

Cholesterol Efflux and Atheroprotection [PDF]

Circulation, 2012
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatory properties, nitric oxide–promoting activity, and ability to transport proteins with their own intrinsic biological activities.1 HDL particles are critical
Robert S, Rosenson, H Bryan, Brewer, W Sean, Davidson, Zahi A, Fayad, Valentin, Fuster, James, Goldstein, Marc, Hellerstein, Xian-Cheng, Jiang, Michael C, Phillips, Daniel J, Rader, Alan T, Remaley, George H, Rothblat, Alan R, Tall, Laurent, Yvan-Charvet   +13 more
openaire   +2 more sources

Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Journal of Cardiovascular Development and Disease, 2023
Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC ...
Olanrewaju Oladosu, Ikechukwu C. Esobi, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +4 more
doaj   +1 more source

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Journal of Lipid Research, 2001
Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.   +5 more
doaj   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Chaitman Bernard R., Nicholls, Stephen J., Mundl, Hardi,, Ballantyne, Christie M,, Nicholls, Stephen J,, Ballantyne, Christie M., Shah, P.K., Ballantyne Christie M., Ballantyne C.M., Chaitman B.R., Wright, R Scott,, McMurray, J.J.V., McMurray, John J V, Mundl, H., Abt Markus, Shah, Prediman K., Schwartz, G.G., McMurray, John J. V., Leiter, Lawrence A,, Leiter, Lawrence A., Barter, Philip J., DE CATERINA, Raffaele, Tardif, Jean-Claude,, Barter, P.J., Leiter L.A., McMurray, J., Brumm, J., Wright, R Scott, Olsson, A.G., Abt, Markus,, Shah Prediman K., dal OUTCOMES Investigators, Leitersdorf, E., Ballantyne, C.M., Kallend, David,, Brumm, Jochen, Mundl Hardi, Shah, Prediman K,, Holme, Ingar M., McMurray, John J V,, Holme, Ingar M,, Brumm Jochen, McMurray J.J., Kallend, David, Goldner, David, Wright, R., Tardif, J., Chaitman, Bernard R,, Wright R. Scott, Shah, P., Chaitman, Bernard R., Chaitman, B., Kallend David, Nicholls, Stephen J, Schwartz Gregory G., Barter, Philip J,, Leiter Lawrence A., Tardif, Jean-Claude, Barter P.J., Barter, P., Abt, Markus, Schwartz, Gregory G., Leiter, Lawrence A, Holme I.M., Olsson, A., The dal-OUTCOMES Investigators, Tardif Jean Claude, Holme, Ingar M, Leitersdorf, Eran, Wright, R.S., Barter Philip J., Schwartz, Gregory G,, Olsson Anders G., Leiter, L.A., Olsson A.G., Olsson, Anders G., Schwartz, Gregory G, Colquhoun, David, Leiter, L., Nicholls, S.J., Barter, Philip J, Chaitman, Bernard R, Brumm, Jochen,, Leitersdorf E., Nicholls, S., Chaitman, B.R., Holme, I.M., Holme, I., Kallend, D., Brumm J., Mundl, Hardi, Shah, Prediman K, Nicholls Stephen J., Wright, R. Scott, McMurray John J. V., Kallend D., Olsson, Anders,, Ballantyne, C., Holme Ingar M., Olsson, Anders G, Abt M., Schwartz G.G., Leitersdorf Eran, Abt, M., Ballantyne, Christie M, Schwartz, G., Leitersdorf, Eran,, GOLINO, Paolo   +107 more
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A new pathway of macrophage cholesterol efflux [PDF]

Proceedings of the National Academy of Sciences, 2020
Macrophage foam cells (i.e., cholesteryl ester-laden macrophages) are abundant in atherosclerotic plaques, and increased macrophage foam cell content is associated with plaque instability (1, 2). Macrophages are generally thought to unload surplus cholesterol via efflux mediated by the ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) to ...
Westerterp, Marit, Tall, Alan R.
openaire   +3 more sources

The roles of different pathways in the release of cholesterol from macrophages

Journal of Lipid Research, 2007
Cholesterol efflux occurs by different pathways, including transport mediated by specific proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release of FC to human serum.
Maria Pia Adorni, Francesca Zimetti, Jeffrey T. Billheimer, Nan Wang, Daniel J. Rader, Michael C. Phillips, George H. Rothblat   +6 more
doaj   +1 more source

Cholesterol efflux from cells enriched with cholesteryl esters by incubation with hypercholesterolemic monkey low density lipoprotein

Journal of Lipid Research, 1983
The mass efflux of free and esterified cholesterol was studied in skin fibroblasts loaded with cholesterol by incubation with low density lipoproteins (LDL) isolated from normal or hypercholesterolemic cynomolgus monkeys.
R W St Clair, M A Leight
doaj   +1 more source