Results 41 to 50 of about 80,716 (308)

Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1s⃞

Journal of Lipid Research, 2007
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver.
Osamu Sano, Aya Kobayashi, Kohjiro Nagao, Keigo Kumagai, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, Michinori Matsuo   +7 more
doaj   +1 more source

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Journal of Lipid Research, 2016
Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs ...
Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke   +7 more
doaj   +1 more source

Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells: different availability and regulation by apolipoprotein A-I.

Journal of Lipid Research, 1995
We have compared the efflux of cholesterol from different cellular pools of human hepatoma cells HepG2 using intact cells or isolated membrane fractions.
D Sviridov, N Fidge
doaj   +1 more source

Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging

Frontiers in Cell and Developmental Biology, 2022
Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess cholesterol.
Alice Dupont Juhl, Daniel Wüstner
doaj   +1 more source

Cholesterol efflux in the transplant patient [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2018
Purpose of review Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients.
Sangita, Sudharshan, Ali, Javaheri
openaire   +2 more sources

Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion

Journal of Lipid Research, 1997
It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
doaj   +1 more source

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]

, 2020
Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro, Betuing, Sandrine, Caboche, Jocelyne, Carmo-Silva, Sara, Cartier, Nathalie, Conceição, André, Costa, Rafael G, Koppenol, Rebekah, Marcelo, Adriana, Matos, Carlos A, Nunes, Ricardo, Nóbrega, Clévio, Sequeira, Raquel L.   +12 more
core   +1 more source

Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages [PDF]

Molecules, 2014
Foam cells formation as a result of the uncontrolled cytophagy of modified cholesterol by macrophages plays a key role in the occurrence and development of atherosclerosis. Sesamin is an active constituent of Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated the effects of sesamin on foam
Nan Liu, Chongming Wu, Lizhong Sun, Jun Zheng, Peng Guo   +4 more
openaire   +3 more sources

The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Biomedicines, 2021
Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality.
Marina Canyelles, Álvaro García-Osuna, Alexandra Junza, Oscar Yanes, Núria Puig, Jordi Ordóñez-Llanos, Alessandro Sionis, Jordi Sans-Roselló, Aitor Alquézar-Arbé, David Santos, Noemi Rotllan, Josep Julve, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca   +14 more
doaj   +1 more source

Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL [PDF]

Current Opinion in Lipidology, 2015
Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects.We review recent evidence that HDL's cholesterol efflux capacity is a strong ...
Patrick M, Hutchins, Jay W, Heinecke
openaire   +2 more sources