Results 41 to 50 of about 50,002 (295)

Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E

Journal of Lipid Research, 1999
In these studies, we have utilized a J774 macrophage model in order to compare phospholipid and cholesterol efflux kinetics in macrophage cells that do not express endogenous apoE to cells transfected to express physiologic levels of human apoE.
Chen-Yi Lin, Hongwei Duan, Theodore Mazzone   +2 more
doaj   +1 more source

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple‐Cell 2D Atherosclerosis Model

, 2022
Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood vessels and carotid intima thickening.
Martín Plágaro, César Augusto, Asier Benito‐Vicente, Iraide Alloza, Martín, César, Alloza Moral, Iraide, Koen Vandenbroeck, Vandenbroeck, Koen, Izortze Santin, Benito-Vicente, Asier, Galicia García, Unai, César Martín, Shifa Jebari‐Benslaiman, Santin, Izortze, Ostolaza, Helena, Unai Galicia‐Garcia, Larrea Sebal, Asier, Kepa B. Uribe, Belloso Uribe, Kepa, Benito Vicente, Asier, Santín Gómez, Izortze, Galicia-García, Unai, Ostolaza Echabe, Elena Amaya, Asier Larrea‐Sebal, Uribe, Kepa B., Larrea, Asier, Helena Ostolaza, Alloza, Iraide, Jebari Benslaiman, Shifa, Jebari-Benslaiman, Shifa   +28 more
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Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

Journal of Lipid Research, 2017
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mice ...
Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R. Lagor, Hannah J. Szapary, Junichiro Tohyama, John S. Millar, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Daniel J. Rader   +10 more
doaj   +1 more source

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels [PDF]

, 2017
Objective-High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues. However, factors regulating lipid efflux are incompletely understood.
Wu, Daniel Heqing, Lidiya G. Dimova, Daniel Heqing Wu, Fabian Dorninger, Angeli, Veronique, Julian C. van Capelleveen, Kang, Martin, Liang Juin Tan, Gopala Krishna Yakala, Uwe J.F. Tietge, Federico Torta, Dorninger, Fabian, Narayanaswamy, Pradeep, G. Kees Hovingh, Dubé, Marie-Pierre, Chris Radomski, Alinda W.M. Schimmel, Lin-Hua Zhang, Ian Tietjen, Chai, Ee Chu, Yakala, Gopala Krishna, Martin Kang, Roshni R. Singaraja, Chung Hwee Thiam, Tietjen, Ian, Dallinga-Thie, Geesje M., Radomski, Chris, Dimova, Lidiya G., Thiam, Chung Hwee, Hayden, Michael R., Tan, Liang Juin, Pradeep Narayanaswamy, Wenk, Markus R., Marie-Pierre Dubé, Trigueros-Motos, Laia, Johannes Berger, Zhang, Lin-Hua, Hovingh, G. Kees, Michael R. Hayden, Laia Trigueros-Motos, Geesje M. Dallinga-Thie, Singaraja, Roshni R., Berger, Johannes, David Castaño, Veronique Angeli, van Capelleveen, Julian C., Ee Chu Chai, Markus R. Wenk, Barhdadi, Amina, Schimmel, Alinda W. M., Tietge, Uwe J. F., Castaño, David, Torta, Federico, Amina Barhdadi   +53 more
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Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia [PDF]

, 2017
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Mansour, Yosef T., Mansour, Yosef T, Mohaupt, Markus G., Line Zurkinden, Zurkinden, Line, Kurlak, Lesia O., Escher, Genevieve, Kurlak, L.O., Mansour, Yosef, Yosef T. Mansour, Mistry, Hiten D., Lesia O. Kurlak, Mohaupt, Markus, Kurlak, Lesia O, Mistry, Hiten D.; id_orcid, Hiten D. Mistry, Markus G. Mohaupt, Geneviève Escher, Mistry, Hiten Dhirubhai   +18 more
core   +1 more source

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Journal of Lipid Research, 2016
Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs ...
Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke   +7 more
doaj   +1 more source

Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells: different availability and regulation by apolipoprotein A-I.

Journal of Lipid Research, 1995
We have compared the efflux of cholesterol from different cellular pools of human hepatoma cells HepG2 using intact cells or isolated membrane fractions.
D Sviridov, N Fidge
doaj   +1 more source

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
core   +1 more source

Connecting Cholesterol Efflux Factors to Lung Cancer Biology and Therapeutics

, 2021
Cholesterol is a foundational molecule of biology. There is a long-standing interest in understanding how cholesterol metabolism is intertwined with cancer biology.
Ryan D. Harris, Maria Maslyanko, David Mu   +2 more
core   +1 more source

The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Biomedicines, 2021
Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality.
Marina Canyelles, Álvaro García-Osuna, Alexandra Junza, Oscar Yanes, Núria Puig, Jordi Ordóñez-Llanos, Alessandro Sionis, Jordi Sans-Roselló, Aitor Alquézar-Arbé, David Santos, Noemi Rotllan, Josep Julve, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca   +14 more
doaj   +1 more source