Results 41 to 50 of about 378,964 (291)

Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells: different availability and regulation by apolipoprotein A-I.

Journal of Lipid Research, 1995
We have compared the efflux of cholesterol from different cellular pools of human hepatoma cells HepG2 using intact cells or isolated membrane fractions.
D Sviridov, N Fidge
doaj   +1 more source

Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging

Frontiers in Cell and Developmental Biology, 2022
Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess cholesterol.
Alice Dupont Juhl, Daniel Wüstner
doaj   +1 more source

Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion

Journal of Lipid Research, 1997
It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
doaj   +1 more source

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels [PDF]

, 2017
Objective-High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues. However, factors regulating lipid efflux are incompletely understood.
Wu, Daniel Heqing, Lidiya G. Dimova, Daniel Heqing Wu, Fabian Dorninger, Angeli, Veronique, Julian C. van Capelleveen, Kang, Martin, Liang Juin Tan, Gopala Krishna Yakala, Uwe J.F. Tietge, Federico Torta, Dorninger, Fabian, Narayanaswamy, Pradeep, G. Kees Hovingh, Dubé, Marie-Pierre, Chris Radomski, Alinda W.M. Schimmel, Lin-Hua Zhang, Ian Tietjen, Chai, Ee Chu, Yakala, Gopala Krishna, Martin Kang, Roshni R. Singaraja, Chung Hwee Thiam, Tietjen, Ian, Dallinga-Thie, Geesje M., Radomski, Chris, Dimova, Lidiya G., Thiam, Chung Hwee, Hayden, Michael R., Tan, Liang Juin, Pradeep Narayanaswamy, Wenk, Markus R., Marie-Pierre Dubé, Trigueros-Motos, Laia, Johannes Berger, Zhang, Lin-Hua, Hovingh, G. Kees, Michael R. Hayden, Laia Trigueros-Motos, Geesje M. Dallinga-Thie, Singaraja, Roshni R., Berger, Johannes, David Castaño, Veronique Angeli, van Capelleveen, Julian C., Ee Chu Chai, Markus R. Wenk, Barhdadi, Amina, Schimmel, Alinda W. M., Tietge, Uwe J. F., Castaño, David, Torta, Federico, Amina Barhdadi   +53 more
core   +2 more sources

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia [PDF]

, 2017
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Mansour, Yosef T., Mansour, Yosef T, Mohaupt, Markus G., Line Zurkinden, Zurkinden, Line, Kurlak, Lesia O., Escher, Genevieve, Kurlak, L.O., Mansour, Yosef, Yosef T. Mansour, Mistry, Hiten D., Lesia O. Kurlak, Mohaupt, Markus, Kurlak, Lesia O, Mistry, Hiten D.; id_orcid, Hiten D. Mistry, Markus G. Mohaupt, Geneviève Escher, Mistry, Hiten Dhirubhai   +18 more
core   +2 more sources

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

Journal of Lipid Research, 2003
Defects in the gene encoding for the ATP binding cassette (ABC) transporter A1 (ABCA1) were shown to be one of the genetic causes for familial hypoalphalipoproteinemia (FHA). We investigated the role of ABCA1-mediated cholesterol efflux in Dutch subjects
G. Kees Hovingh, Michel J.A. van Wijland, Alison Brownlie, Radjesh J. Bisoendial, Michael R. Hayden, John J.P. Kastelein, Albert K. Groen   +6 more
doaj   +1 more source

Polyphenols and Cholesterol Efflux [PDF]

Circulation Research, 2010
Despite strong evidence for an inverse association between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular risk,1 successful therapeutic strategies to target HDL have remained elusive. A recent Phase III clinical trial failed to show clinical benefit with the cholesteryl ester transfer protein inhibitor torcetrapib despite ...
Megan F, Burke, Amit V, Khera, Daniel J, Rader   +2 more
openaire   +2 more sources

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]

Endocrinology and Metabolism, 2017
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
doaj   +1 more source

The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Biomedicines, 2021
Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality.
Marina Canyelles, Álvaro García-Osuna, Alexandra Junza, Oscar Yanes, Núria Puig, Jordi Ordóñez-Llanos, Alessandro Sionis, Jordi Sans-Roselló, Aitor Alquézar-Arbé, David Santos, Noemi Rotllan, Josep Julve, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca   +14 more
doaj   +1 more source

Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]

, 2012
This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core   +1 more source