Results 51 to 60 of about 50,002 (295)

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

Journal of Lipid Research, 2003
Defects in the gene encoding for the ATP binding cassette (ABC) transporter A1 (ABCA1) were shown to be one of the genetic causes for familial hypoalphalipoproteinemia (FHA). We investigated the role of ABCA1-mediated cholesterol efflux in Dutch subjects
G. Kees Hovingh, Michel J.A. van Wijland, Alison Brownlie, Radjesh J. Bisoendial, Michael R. Hayden, John J.P. Kastelein, Albert K. Groen   +6 more
doaj   +1 more source

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 [PDF]

Journal of Lipid Research, 2006
Cholesterol and phospholipids are essential to the body, but an excess of cholesterol or lipids is toxic and a risk factor for arteriosclerosis. ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis. To explore the role of ABCG1 in cholesterol homeostasis, we examined its subcellular localization and function ...
Aya Kobayashi, Yasukazu Takanezawa, Takashi Hirata, Yuji Shimizu, Keiko Misasa, Noriyuki Kioka, Hiroyuki Arai, Kazumitsu Ueda, Michinori Matsuo   +8 more
openaire   +3 more sources

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]

Endocrinology and Metabolism, 2017
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
doaj   +1 more source

Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]

, 2012
This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core   +1 more source

Polyphenols and Cholesterol Efflux [PDF]

Circulation Research, 2010
Despite strong evidence for an inverse association between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular risk,1 successful therapeutic strategies to target HDL have remained elusive. A recent Phase III clinical trial failed to show clinical benefit with the cholesteryl ester transfer protein inhibitor torcetrapib despite ...
Megan F, Burke, Amit V, Khera, Daniel J, Rader   +2 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs

Journal of Translational Medicine, 2019
Background Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity. Methods We
Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss, Robert J. Freishtat   +14 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Cholesterol Efflux Capacity and Cardiovascular Disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

Biomedicines, 2020
(1) Background and Aims: Efforts to reduce coronary artery disease (CAD) by raising high-density lipoprotein (HDL) cholesterol (HDL-C) have not been uniformly successful.
Andreas Ritsch, Angela Duerr, Patrick Kahler, Monika Hunjadi, Tatjana Stojakovic, Guenther Silbernagel, Hubert Scharnagl, Marcus E. Kleber, Winfried März   +8 more
doaj   +1 more source

Regulation and mechanisms of macrophage cholesterol efflux [PDF]

Journal of Clinical Investigation, 2002
The accumulation of cholesterol in macrophage foam cells results from the uptake of retained and modified apoB lipoproteins (1) and is a central event in atherogenesis. Although it has long been known that HDL and its apolipoproteins can stimulate cholesterol efflux from macrophage foam cells (2, 3) and reduce atherogenesis in animal models (4, 5 ...
Alan R, Tall, Philippe, Costet, Nan, Wang   +2 more
openaire   +2 more sources