Results 71 to 80 of about 50,002 (295)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The Measurement of High-Density Lipoprotein Mediated Cholesterol Efflux from Macrophage Cells by Liquid Chromatography Tandem Mass Spectrometry

Cellular Physiology and Biochemistry, 2014
Background: Studies have shown a negative association between macrophage cholesterol efflux and atherosclerotic cardiovascular diseases (CVD). However, the current methods for measuring cholesterol efflux require a radioactive tracer and involve a ...
Mo Wang, Hanbang Guo, Siming Wang, Ruiyue Yang, Hongxia Li, Haijian Zhao, Shu Wang, Jun Dong, Wenxiang Chen   +8 more
doaj   +1 more source

Familial hypercholesterolaemia : cholesterol efflux and coronary disease [PDF]

, 2016
Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux ...
Sijbrands, E.J.G.; id_orcid, John P. Kane, Yahya, Reyhana, Christoffersen, C. (Christina), Clive R. Pullinger, Versmissen, Jorie, Ranitha Vongpromek, Reyhana Yahya, Sijbrands, E.J.G., Kane, J.P. (John), Yahya , Reyhana, Jeannette Blommesteijn‐Touw, Rietveld, T. (Trinet), Christoffersen, Christina, Yahya, R. (Reyhana), Christina Christoffersen, Yahya, Reyhana,, Van der Zee - van Vark, Leonie, Versmissen, Jorie,, Björn Dahlbäck, Vark-van der Zee, L.C. (Leonie) van, Christoffersen, C, Sijbrands, E.J.G. (Eric), Mulder, M.T. (Monique), van der Net, Jeroen B, Kane, John P.,, Blommesteijn-Touw, J. (Jeannette), Dahlback, B, Mulder, Monique, Vongpromek, Ranitha, Wattimena, J. L. Darcos, Pullinger, Clive R.,, Blommesteijn, Jeanette, Jorie Versmissen, Lund University., Trinet Rietveld, Versmissen, J. (Jorie), van der Net, Jeroen B., Net, Jeroen, Darcos Wattimena, Wattimena, Darcos,, Pullinger, Clive R., Kane, John P., Pullinger, C.R. (Clive), Jeroen B. van der Net, Blommesteijn-Touw, Jeannette,, Rietveld, Trinet,, Pullinger, Clive R, Leonie van Vark‐van der Zee, van der Net, Jeroen B.,, van Vark-van der Zee, Leonie, Vongpromek, Ranitha,, Dahlbäck, Björn, Sijbrands, Eric J G,, Christoffersen, Christina,, Wattimena, Darcos, Rietveld, Trinet, Mulder, Maarten, Sijbrands, Eric J. G., Eric J. G. Sijbrands, Monique Mulder, Kane, JP, Mulder, Monique,, Vongpromek, R. (Ranitha), Kane, John P, Sijbrands, Eric J G, van Vark-van der Zee, Leonie,, Pullinger, CR, Net, J.B. (Jeroen) van der, Dahlbäck, B. (Björn), Dahlbäck, Björn,, Wattimena, J.L.D. (Josias), Blommesteijn-Touw, Jeannette   +72 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background The contribution of high‐density lipoprotein to cardiovascular benefit is closely linked to its role in the cellular cholesterol efflux process; however, various clinical and biochemical variables are known to modulate the overall cholesterol ...
Julie Gall, Eric Frisdal, Randa Bittar, Wilfried Le Goff, Eric Bruckert, Philippe Lesnik, Maryse Guerin, Philippe Giral   +7 more
doaj   +1 more source

Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality

Biomedicines, 2022
Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD).
Andreas Ritsch, Monika Hunjadi, Tatjana Stojakovic, Jürgen E. Scherberich, Günther Silbernagel, Hubert Scharnagl, Graciela E. Delgado, Marcus E. Kleber, Winfried März   +8 more
doaj   +1 more source

PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux [PDF]

The Journal of Neuroscience, 2019
The absence of functional peripheral myelin protein 22 (PMP22) is associated with shortened lifespan in rodents and severe peripheral nerve myelin abnormalities in several species including humans. Schwann cells and nerves from PMP22 knock-out (KO) mice show deranged cholesterol distribution and aberrant lipid raft morphology, supporting an ...
Ye Zhou, Joshua R. Miles, Hagai Tavori, Min Lin, Habibeh Khoshbouei, David R. Borchelt, Hannah Bazick, Gary E. Landreth, Sooyeon Lee, Sergio Fazio, Lucia Notterpek   +10 more
openaire   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels

Angewandte Chemie, EarlyView.
Here we demonstrate that weak HB CH donor cyanostilbenes promote water/ion transport through their ability to form less‐ordered transient water channels within the lipid bilayer with increased water permeability and NO3−/ Cl− selectivity. ABSTRACT Transmembrane water transport strongly depends on how dynamic, translocating water clusters are stabilized
Ioan Stroia, Dan‐Dan Su, Yuhao Li, Niculina Hadade, Ion Grosu, Arie van der Lee, Mihail Barboiu   +6 more
wiley   +2 more sources

ABC Transporters, Cholesterol Efflux, and Implications for Cardiovascular Diseases [PDF]

, 2020
Most types of cells in the body have no or very limited capacity of catabolizing cholesterol, so cholesterol efflux is essential for cholesterol homeostasis. There are multiple mechanisms responsible for cellular cholesterol efflux.
Nan Wang, Wang, Nan, Westerterp, Marit; id_orcid, Marit Westerterp, Westerterp, Marit   +4 more
core   +2 more sources