Results 91 to 100 of about 50,002 (295)

Cholesterol Efflux Capacity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
High-density lipoprotein cholesterol (HDL-C) levels represent a robust and well-integrated biomarker of cardiovascular risk. The prevalence of low HDL-C is high and likely to increase in coming years in parallel with the epidemic of obesity and type 2 diabetes mellitus.
Amit V, Khera, Daniel J, Rader
openaire   +2 more sources

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1

, 2004
Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and ...
van Tol, A., Fournier, C., Beulens, J.W.J., Sierksma, A.   +3 more
core   +3 more sources

Inhibition of miR-33a-5p in Macrophage-like Cells In Vitro Promotes apoAI-Mediated Cholesterol Efflux

Pathophysiology
Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where atherosclerotic plaque accumulates and where lipid-laden foam cells reside.
Olanrewaju Oladosu, Emma Chin, Christian Barksdale, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +5 more
doaj   +1 more source

Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity[S]

Journal of Lipid Research, 2015
Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
Tomáš Vaisar, Chongren Tang, Ilona Babenko, Patrick Hutchins, Jake Wimberger, Anthony F. Suffredini, Jay W. Heinecke   +6 more
doaj   +1 more source

Nef Targets ABCA1-Dependent Cholesterol Efflux

, 2013
(A) Cholesterol efflux to HDL (30 μg/ml) was measured from HIV-1 ADA-infected and mock-infected macrophages used also to measure efflux to apoA-I in Figure 1A. (B) Impairment of phospholipid efflux in Nef-transfected RAW 264.7 cells.
Anthony Dart (379546), Honor Rose (379544), Dmitri Sviridov (54259), Matthew P Morrow (379545), Larisa Dubrovsky (45091), Jan M Orenstein (1871), Yuri V Bobryshev (379547), Ying Fu (173963), Zahedi Mujawar (379543), Nigora Mukhamedova (54252), Tatiana Pushkarsky (363651), Michael Bukrinsky (45092)   +11 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Differential rate of cholesterol efflux from the apical and basolateral membranes of MDCK cells

Journal of Lipid Research, 1998
Epithelial cells contain two distinct membrane surfaces, the apical and basolateral plasma membranes, which have different lipid and protein compositions.
A.T. Remaley, B.D. Farsi, A.C. Shirali, J.M. Hoeg, H.B. Brewer, Jr.   +4 more
doaj   +1 more source

Apolipoprotein A-I and Cholesterol Efflux [PDF]

Circulation Research, 2014
High-density lipoprotein (HDL) cholesterol is strongly and inversely associated with coronary heart disease. However, recent developments have raised major questions about the causal nature of this relationship. Several randomized controlled clinical trials of HDL-raising interventions have failed to demonstrate reduction in risk of major adverse ...
Ali, Javaheri, Daniel J, Rader
openaire   +2 more sources

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source