Results 1 to 10 of about 44,530 (269)

Metrics of High-Density Lipoprotein Function and Hospital Mortality in Acute Heart Failure Patients. [PDF]

PLoS ONE, 2016
ObjectiveThe functionality of high-density lipoprotein (HDL) is impaired in chronic ischaemic heart failure (HF). However, the relationship between HDL functionality and outcomes in acute HF (AHF) has not been studied.
Ines Potočnjak, Vesna Degoricija, Matias Trbušić, Sanda Dokoza Terešak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Beate Tiran, Gunther Marsche, Saša Frank   +9 more
doaj   +8 more sources

Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19 [PDF]

Antioxidants, 2022
Plasma membrane cholesterol is required for proper trafficking and localization of receptors that facilitate severe acute respiratory syndrome coronavirus 2 infection.
Julia T. Stadler, Harald Mangge, Alankrita Rani, Pero Curcic, Markus Herrmann, Florian Prüller, Gunther Marsche   +6 more
doaj   +2 more sources

Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity[S] [PDF]

Journal of Lipid Research, 2015
Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
Tomáš Vaisar, Chongren Tang, Ilona Babenko, Patrick Hutchins, Jake Wimberger, Anthony F. Suffredini, Jay W. Heinecke   +6 more
doaj   +3 more sources

Serum Cholesterol Efflux Capacity in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy [PDF]

Ophthalmology Science, 2022
Purpose: To investigate serum cholesterol efflux capacity (the ability of the serum to accept cholesterol) and factors that regulate it using nuclear magnetic resonance-quantified measures of lipoprotein particle composition and size and apolipoproteins ...
Yasuo Yanagi, MD, PhD, Richard M.C. Yu, PhD, Waseem Ahamed, MS, Marco Yu, PhD, Kelvin Yi Chong Teo, MBBS, MMed (Ophth), Anna C.S. Tan, MBBS, Ching-Yu Cheng, MD, PhD, Tien Yin Wong, MD, PhD, Rajendra S. Apte, MD, PhD, Chui Ming Gemmy Cheung, FRCOphth   +9 more
doaj   +2 more sources

Uremia alters HDL composition and cholesterol efflux capacity [PDF]

BMC Pharmacology and Toxicology, 2012
Results We identified a significant increase in the amount of acute-phase protein serum amyloid A1, albumin, lipoprotein-associated phospholipase A2, and apoC-III composing uremic HDL. Furthermore, uremic HDL contained reduced phospholipids and increased triglycerides and lysophospholipids. With regard to function, these changes impaired the ability of
Christian Wadsack, Dalia El-Gamal, Gunther Marsche, Michael Holzer, Ruth Birner-Grünberger, Tatjana Stojaković, Veronika Binder, Ákos Heinemann   +7 more
core   +3 more sources

Antiatherosclerotic Effects of CSL112 Mediated by Enhanced Cholesterol Efflux Capacity. [PDF]

J Am Heart Assoc, 2022
Approximately 12% of patients with acute myocardial infarction (AMI) experience a recurrent major adverse cardiovascular event within 1 year of their primary event, with most occurring within the first 90 days. Thus, there is a need for new therapeutic approaches that address this 90‐day post‐AMI high‐risk period.
Kingwell BA, Nicholls SJ, Velkoska E, Didichenko SA, Duffy D, Korjian S, Gibson CM.   +6 more
europepmc   +4 more sources

Molecular Patterns of Extreme and Persistent Cholesterol Efflux Capacity. [PDF]

Arterioscler Thromb Vasc Biol, 2021
Objective: Cholesterol efflux capacity (CEC), the ability of extracellular acceptors to pick-up cholesterol from macrophages, is a clinically relevant cardiovascular biomarker. CEC is inversely associated with incident atherosclerotic cardiovascular disease events.
El-Ghazali A, Deodhar S, Saldanha S, Smyth B, Izbrand M, Gangwar A, Pahlavani M, Rohatgi A.   +7 more
europepmc   +3 more sources

ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity [PDF]

Scientific Reports, 2017
Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL.
Mengdie Luo, Aiying Liu, Shuai Wang, Tianle Wang, Die Hu, Sha Wu, Daoquan Peng   +6 more
doaj   +3 more sources

Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity. [PDF]

Front Cardiovasc Med
BackgroundBariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality.AimTo assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in ...
Castañer O, Pérez-Vega KA, Álvarez S, Vázquez S, Casajoana A, Blanchart G, Gaixas S, Schröder H, Zomeño MD, Subirana I, Muñoz-Aguayo D, Fitó M, Benaiges D, Goday A, Oliveras A.   +14 more
europepmc   +5 more sources

Development and validation of novel automatable assay for cholesterol efflux capacity. [PDF]

Biosci Rep, 2023
Abstract During the past decade, evaluation of high-density lipoprotein (HDL) functionality has been well studied for predicting cardiovascular disease (CVD) risk. Cholesterol efflux capacity (CEC) is the strongest candidate as the biomarker out of various HDL antiatherosclerotic functions.
Mutsuda Y, Miyakoshi T, Horiuchi Y, Kameda T, Tozuka M, Ohkawa R.   +5 more
europepmc   +3 more sources