Results 21 to 30 of about 44,530 (269)

Impaired High‐Density Lipoprotein Function in Patients With Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure.
Johanna E. Emmens, Congzhuo Jia, Leong L. Ng, Dirk J. van Veldhuisen, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Gerasimos Filippatos, John G. F. Cleland, Marco Metra, Adriaan A. Voors, Rudolf A. de Boer, Uwe J. F. Tietge   +12 more
doaj   +1 more source

Relationship of Para and Perirenal Fat and High-Density Lipoprotein and Its Function in Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2021
Background. Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension.
Jing Ke, Yan Wang, Simo Liu, Kun Li, YueChao Xu, Longyan Yang, Dong Zhao   +6 more
doaj   +1 more source

Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

Annals of Medicine, 2022
Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver.
Marco Magnoni, Daniele Andreini, Angela Pirillo, Patrizia Uboldi, Roberto Latini, Alberico L. Catapano, Aldo P. Maggioni, Giuseppe D. Norata   +7 more
doaj   +1 more source

Cholesterol Efflux Capacity, Carotid Atherosclerosis, and Cerebrovascular Symptomatology [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Objective— To investigate the association of cholesterol efflux capacity with carotid atherosclerosis and cerebrovascular disease. Approach and Results— Patients with high-grade carotid stenosis (n=154) were recruited from Vascular Surgery clinics and 9 healthy ...
R J, Doonan, A, Hafiane, C, Lai, J P, Veinot, J, Genest, S S, Daskalopoulou   +5 more
openaire   +2 more sources

Tweaking the cholesterol efflux capacity of reconstituted HDL [PDF]

Biochemistry and Cell Biology, 2012
Mechanisms to increase plasma high-density lipoprotein (HDL) or to promote egress of cholesterol from cholesterol-loaded cells (e.g., foam cells from atherosclerotic lesions) remain an important target to regress heart disease. Reconstituted HDL (rHDL) serves as a valuable vehicle to promote cellular cholesterol efflux in vitro and in vivo.
Cheng-I J, Ma, Jennifer A, Beckstead, Airlia, Thompson, Anouar, Hafiane, Rui Hao Leo, Wang, Robert O, Ryan, Robert S, Kiss   +6 more
openaire   +2 more sources

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Journal of Lipid Research, 2016
Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs ...
Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke   +7 more
doaj   +1 more source

ABCA1‐Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundAnimal and human studies indicate that ABCA1‐mediated cholesterol transport is important in Alzheimer's disease (AD). We hypothesized that the efficiency of cerebrospinal fluid (CSF) to facilitate ABCA1‐mediated cholesterol efflux would be ...
Hussein N. Yassine, Qingru Feng, Jiarong Chiang, Larissa M. Petrosspour, Alfred N. Fonteh, Helena C. Chui, Michael G. Harrington   +6 more
doaj   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
AbstractContextElevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages may be an antiatherogenic process. Plasminogen (PLG) is a driver of ABCA1-mediated cholesterol efflux, and its action is inhibited by purified human Lp(a).ObjectiveTo determine the ...
Hagai Tavori, Alexandra M Fenton, Deanna L Plubell, Sara Rosario, Elisabeth Yerkes, Rayna Gasik, Joshua Miles, Paige Bergstrom, Jessica Minnier, Sergio Fazio, Nathalie Pamir   +10 more
openaire   +2 more sources

Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART[S]

Journal of Lipid Research, 2015
The capacity of HDL to remove cholesterol from macrophages is inversely associated with the severity of angiographic coronary artery disease. The effect of human immunodeficiency virus (HIV) infection or its treatment on the ability of HDL particles to ...
Petra El Khoury, Mathilde Ghislain, Elise F. Villard, Wilfried Le Goff, Caroline Lascoux-Combe, Patrick Yeni, Laurence Meyer, Corinne Vigouroux, Cécile Goujard, Maryse Guerin   +9 more
doaj   +1 more source