Results 21 to 30 of about 24,401 (257)
Antiatherosclerotic Effects of CSL112 Mediated by Enhanced Cholesterol Efflux Capacity. [PDF]
J Am Heart Assoc, 2022 Approximately 12% of patients with acute myocardial infarction (AMI) experience a recurrent major adverse cardiovascular event within 1 year of their primary event, with most occurring within the first 90 days. Thus, there is a need for new therapeutic approaches that address this 90‐day post‐AMI high‐risk period.
Kingwell BA +6 more
europepmc +4 more sources
Cholesterol Efflux Capacity as a Therapeutic Target [PDF]
Journal of the American College of Cardiology, 2015 HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL inversely associated with prevalent and incident cardiovascular disease.
Rohatgi, Anand, Grundy, Scott M.
+7 more sources
Moderate‐ and High‐Intensity Exercise Improves Lipoprotein Profile and Cholesterol Efflux Capacity in Healthy Young Men [PDF]
Journal of the American Heart Association, 2022 Wendy Jessup +2 more
exaly +2 more sources
Molecular Patterns of Extreme and Persistent Cholesterol Efflux Capacity. [PDF]
Arterioscler Thromb Vasc Biol, 2021 Objective: Cholesterol efflux capacity (CEC), the ability of extracellular acceptors to pick-up cholesterol from macrophages, is a clinically relevant cardiovascular biomarker. CEC is inversely associated with incident atherosclerotic cardiovascular disease events.
El-Ghazali A +7 more
europepmc +3 more sources
Cholesterol Efflux Capacity [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 High-density lipoprotein cholesterol (HDL-C) levels represent a robust and well-integrated biomarker of cardiovascular risk. The prevalence of low HDL-C is high and likely to increase in coming years in parallel with the epidemic of obesity and type 2 diabetes mellitus.
Amit V, Khera, Daniel J, Rader
openaire +2 more sources
Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
Biomedicines, 2022 Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD).
Andreas Ritsch +8 more
doaj +1 more source
Tweaking the cholesterol efflux capacity of reconstituted HDL [PDF]
Biochemistry and Cell Biology, 2012 Mechanisms to increase plasma high-density lipoprotein (HDL) or to promote egress of cholesterol from cholesterol-loaded cells (e.g., foam cells from atherosclerotic lesions) remain an important target to regress heart disease. Reconstituted HDL (rHDL) serves as a valuable vehicle to promote cellular cholesterol efflux in vitro and in vivo.
Cheng-I J, Ma +6 more
openaire +2 more sources
Impaired High‐Density Lipoprotein Function in Patients With Heart Failure
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure.
Johanna E. Emmens +12 more
doaj +1 more source
International Journal of Endocrinology, 2021 Background. Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension.
Jing Ke +6 more
doaj +1 more source
Annals of Medicine, 2022 Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver.
Marco Magnoni +7 more
doaj +1 more source