Results 41 to 50 of about 24,401 (257)

Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs

Journal of Translational Medicine, 2019
Background Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity. Methods We
Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss, Robert J. Freishtat   +14 more
doaj   +1 more source

HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity

Journal of Lipid Research, 2015
HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL ...
Mark S. Borja, Kit F. Ng, Angela Irwin, Jaekyoung Hong, Xing Wu, Daniel Isquith, Xue-Qiao Zhao, Bryan Prazen, Virginia Gildengorin, Michael N. Oda, Tomáš Vaisar   +10 more
doaj   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Chaitman Bernard R., Nicholls, Stephen J., Mundl, Hardi,, Ballantyne, Christie M,, Nicholls, Stephen J,, Ballantyne, Christie M., Shah, P.K., Ballantyne Christie M., Ballantyne C.M., Chaitman B.R., Wright, R Scott,, McMurray, J.J.V., McMurray, John J V, Mundl, H., Abt Markus, Shah, Prediman K., Schwartz, G.G., McMurray, John J. V., Leiter, Lawrence A,, Leiter, Lawrence A., Barter, Philip J., DE CATERINA, Raffaele, Tardif, Jean-Claude,, Barter, P.J., Leiter L.A., McMurray, J., Brumm, J., Wright, R Scott, Olsson, A.G., Abt, Markus,, Shah Prediman K., dal OUTCOMES Investigators, Leitersdorf, E., Ballantyne, C.M., Kallend, David,, Brumm, Jochen, Mundl Hardi, Shah, Prediman K,, Holme, Ingar M., McMurray, John J V,, Holme, Ingar M,, Brumm Jochen, McMurray J.J., Kallend, David, Goldner, David, Wright, R., Tardif, J., Chaitman, Bernard R,, Wright R. Scott, Shah, P., Chaitman, Bernard R., Chaitman, B., Kallend David, Nicholls, Stephen J, Schwartz Gregory G., Barter, Philip J,, Leiter Lawrence A., Tardif, Jean-Claude, Barter P.J., Barter, P., Abt, Markus, Schwartz, Gregory G., Leiter, Lawrence A, Holme I.M., Olsson, A., The dal-OUTCOMES Investigators, Tardif Jean Claude, Holme, Ingar M, Leitersdorf, Eran, Wright, R.S., Barter Philip J., Schwartz, Gregory G,, Olsson Anders G., Leiter, L.A., Olsson A.G., Olsson, Anders G., Schwartz, Gregory G, Colquhoun, David, Leiter, L., Nicholls, S.J., Barter, Philip J, Chaitman, Bernard R, Brumm, Jochen,, Leitersdorf E., Nicholls, S., Chaitman, B.R., Holme, I.M., Holme, I., Kallend, D., Brumm J., Mundl, Hardi, Shah, Prediman K, Nicholls Stephen J., Wright, R. Scott, McMurray John J. V., Kallend D., Olsson, Anders,, Ballantyne, C., Holme Ingar M., Olsson, Anders G, Abt M., Schwartz G.G., Leitersdorf Eran, Abt, M., Ballantyne, Christie M, Schwartz, G., Leitersdorf, Eran,, GOLINO, Paolo   +107 more
core   +1 more source

Age-related impairment of HDL-mediated cholesterol efflux

Journal of Lipid Research, 2007
Our aim in this study was to investigate the effect of aging on the capacity of HDLs to promote reverse cholesterol transport. HDLs were isolated from plasma of young (Y-HDL) and elderly (E-HDL) subjects. HDL-mediated cholesterol efflux was studied using
Hicham Berrougui, Maxim Isabelle, Martin Cloutier, Guillaume Grenier, Abdelouahed Khalil   +4 more
doaj   +1 more source

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Cholesterol Efflux Capacity and Its Association with Oxidative Stress in Myocardial Infarction. [PDF]

J Atheroscler Thromb
Endo Y, Sasaki K, Ikewaki K.
europepmc   +3 more sources

Association between cholesterol efflux capacity and metabolic syndrome.

, 2021
(A) CEC-Radiolabeled. (B) CEC-Fluorescent. Odds ratio = standardized odds ratio. Participant with no history of metabolic syndrome and Q1, participants in first quartile of cholesterol efflux capacity, as reference groups.
Parag H. Joshi (11462674), Anand Rohatgi (4917304), Ian J. Neeland (3124149), Oludamilola Akinmolayemi (11462668), Suzanne Saldanha (11462671), Sneha Deodhar (4705870), Colby R. Ayers (11462677)   +6 more
core   +1 more source

Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
AbstractContextElevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages may be an antiatherogenic process. Plasminogen (PLG) is a driver of ABCA1-mediated cholesterol efflux, and its action is inhibited by purified human Lp(a).ObjectiveTo determine the ...
Hagai Tavori, Alexandra M Fenton, Deanna L Plubell, Sara Rosario, Elisabeth Yerkes, Rayna Gasik, Joshua Miles, Paige Bergstrom, Jessica Minnier, Sergio Fazio, Nathalie Pamir   +10 more
openaire   +2 more sources

Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

eLife, 2021
After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols.
Drew Wilfahrt, Rachael L Philips, Jyoti Lama, Monika Kizerwetter, Michael Jeremy Shapiro, Shaylene A McCue, Madeleine M Kennedy, Matthew J Rajcula, Hu Zeng, Virginia Smith Shapiro   +9 more
doaj   +1 more source

Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis [PDF]

Atherosclerosis, 2012
Psoriasis is a Th-1/17 mediated inflammatory disease associated with increased risk of cardiovascular disease (CVD). Inflammation may modulate lipoprotein particle number and directly impair HDL functions, in particular reverse cholesterol transport (RCT).
Nehal N, Mehta, Ron, Li, Parasuram, Krishnamoorthy, YiDing, Yu, William, Farver, Amrith, Rodrigues, Anna, Raper, Mackenzie, Wilcox, Amanda, Baer, Stephanie, DerOhannesian, Megan, Wolfe, Muredach P, Reilly, Daniel J, Rader, Abby, VanVoorhees, Joel M, Gelfand   +14 more
openaire   +2 more sources