Results 51 to 60 of about 24,401 (257)
Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis [PDF]
New England Journal of Medicine, 2011 High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden.We measured cholesterol efflux capacity in 203 healthy volunteers who underwent assessment ...
Amit V, Khera +12 more
openaire +2 more sources
Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report [PDF]
, 2016 Objective-Patients with type 2 diabetes mellitus (T2D) have an increased risk of cardiovascular disease, the mechanism of which is incompletely understood.
Apro, Johanna +11 more
core +1 more source
Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjectss⃞
Journal of Lipid Research, 2008 We evaluated the impact of gender differences in both the quantitative and qualitative features of HDL subspecies on cellular free cholesterol efflux through the scavenger receptor class B type I (SR-BI), ABCA1, and ABCG1 pathways.
Giovanna Catalano +6 more
doaj +1 more source
HDL Functions—Current Status and Future Perspectives
Biomolecules, 2023 Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically ...
Yasuhiro Endo +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum [PDF]
Clinical Chemistry, 2018 Abstract BACKGROUND HDL-mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have a protective role in atherogenesis. However, the estimation of HDL-CEC is based on in vitro cell assays that are laborious and hamper large-scale phenotyping.
Kuusisto, Sanna +9 more
openaire +5 more sources
Journal of Lipid Research, 2015 The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi +9 more
doaj +1 more source
SAA: a link between cholesterol efflux capacity and inflammation?1 [PDF]
Journal of Lipid Research, 2015 Serum amyloid A (SAA) concentration in plasma increases markedly following infl ammation or infection, with the liver being the principal site of its synthesis. SAA was fi rst reported to be associated with both human and animal HDLs in the late 1970s ( 1 ), but is also associated with other lipoprotein fractions ( 2 , 3 ).
Michael J. Thomas, Mary G. Sorci-Thomas
doaj +3 more sources
Cholesterol efflux capacity of HDL fractions from ApoF KO mice.
, 2012 Serum was collected from wild type and ApoF KO mice for the measurement of cholesterol efflux capacity.. Apo B lipoproteins were precipitated with polyethylene glycol, and the resulting supernatant (containing HDL and other soluble serum proteins) was ...
Sumeet A. Khetarpal (182252) +11 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang +13 more
wiley +1 more source