Results 11 to 20 of about 24,401 (257)

Effect of a PCSK9 inhibitor and a statin on cholesterol efflux capacity: A limitation of current cholesterol-lowering treatments? [PDF]

Eur J Clin Invest, 2022
Background: Cellular cholesterol efflux is a key step in reverse cholesterol transport that may impact on atherosclerotic cardiovascular risk. The process may be reliant on the availability of apolipoprotein (apo) B-100 containing lipoproteins to accept ...
Ying Q, Ronca A, Chan DC, Pang J, Favari E, Watts GF.   +5 more
europepmc   +5 more sources

Cholesterol efflux capacity.

Journal of the American College of Cardiology, 2016
Apolipoprotein B (apoB)-depleted sera of healthy subjects (control, n = 27) and patients with age-related macular degeneration (AMD, n = 29) were examined for (A) their ability to promote [3H]-cholesterol efflux from macrophages. [3H]-cholesterol-labeled
Anton Haas (420487), Silke Hausberger (755976), Sabine Kern (3171669), Markus Trieb (3171666), Hubert Scharnagl (435522), Gunther Marsche (312903), Akos Heinemann (142582), Laura Pertl (755975), Vanessa Gasser-Steiner (3171672), Martin Weger (403811)   +9 more
core   +2 more sources

Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity[S] [PDF]

Journal of Lipid Research, 2015
Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
Tomáš Vaisar, Chongren Tang, Ilona Babenko, Patrick Hutchins, Jake Wimberger, Anthony F. Suffredini, Jay W. Heinecke   +6 more
doaj   +3 more sources

Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy [PDF]

Atherosclerosis Plus, 2022
Background and aims: Preeclampsia (PE) is associated with life-long increased risk of cardiovascular disease. One of the main protective functions of high-density lipoprotein (HDL) is its role in reverse cholesterol transport.
Maaike Kockx, Lynne Roberts, Jeffrey Wang, Collin Tran, Mark A. Brown, Leonard Kritharides   +5 more
doaj   +2 more sources

Association of Serum Cholesterol Efflux Capacity With Mortality in Patients With ST-Segment Elevation Myocardial Infarction

Journal of the American College of Cardiology, 2018
International audienceBACKGROUND: Serum cholesterol efflux capacity, a biomarker that integrates contributors and modulators of the initial step of the reverse cholesterol transport, has been associated with atherosclerosis independently of high-density ...
Maryse Guerin, Johanne Silvain, Masoud Darabi   +2 more
exaly   +2 more sources

Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1

Journal of Lipid Research, 2004
Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and ...
J.W.J. Beulens, A. Sierksma, A. van Tol, N. Fournier, T. van Gent, J-L. Paul, H.F.J. Hendriks   +6 more
doaj   +3 more sources

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1. [PDF]

J Lipid Res
The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma.
Sarkar S, Morris J, You Y, Sexmith H, Street SE, Thibert SM, Attah IK, Hutchinson Bunch CM, Novikova IV, Evans JE, Shah AS, Gordon SM, Segrest JP, Bornfeldt KE, Vaisar T, Heinecke JW, Davidson WS, Melchior JT.   +17 more
europepmc   +2 more sources

Psoriasis alters HDL composition and cholesterol efflux capacity[S] [PDF]

Journal of Lipid Research, 2012
Psoriasis, a chronic inflammatory skin disease, has been linked to increased myocardial infarction and stroke. Functional impairment of HDL may contribute to the excess cardiovascular mortality of psoriatic patients. However, data available regarding the
Michael Holzer, Peter Wolf, Sanja Curcic, Ruth Birner-Gruenberger, Wolfgang Weger, Martin Inzinger, Dalia El-Gamal, Christian Wadsack, Akos Heinemann, Gunther Marsche   +9 more
doaj   +3 more sources

Genetic Determination of Plasma Cholesterol Efflux Capacity Is Gender-Specific and Independent of HDL-Cholesterol Levels [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
International audienceObjective— We investigated the impact of several genetic variants located in genes encoding for proteins involved in biogenesis, maturation, and intravascular remodeling of high density lipoprotein (HDL) particles on plasma efflux ...
Bonnefont-Rousselot, Dominique, M. Guerin, Le Goff, Wilfried, P. EI Khoury, Guerin, Maryse, Ei Khoury, Petra, Bittar, Randa, D. Bonnefont-Rousselot, Clement, Karine, E. Frisdal, E. Bruckert, Frisdal, Eric, W. Le Goff, K. Clement, Bruckert, Eric, R. Bittar, Villard, Elise, E. F. Villard   +17 more
core   +4 more sources

Development and validation of novel automatable assay for cholesterol efflux capacity. [PDF]

Biosci Rep, 2023
Abstract During the past decade, evaluation of high-density lipoprotein (HDL) functionality has been well studied for predicting cardiovascular disease (CVD) risk. Cholesterol efflux capacity (CEC) is the strongest candidate as the biomarker out of various HDL antiatherosclerotic functions.
Mutsuda Y, Miyakoshi T, Horiuchi Y, Kameda T, Tozuka M, Ohkawa R.   +5 more
europepmc   +3 more sources