Results 11 to 20 of about 44,530 (269)

Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis [PDF]

New England Journal of Medicine, 2011
High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden.We measured cholesterol efflux capacity in 203 healthy volunteers who underwent assessment ...
Amit V, Khera, Marina, Cuchel, Margarita, de la Llera-Moya, Amrith, Rodrigues, Megan F, Burke, Kashif, Jafri, Benjamin C, French, Julie A, Phillips, Megan L, Mucksavage, Robert L, Wilensky, Emile R, Mohler, George H, Rothblat, Daniel J, Rader   +12 more
exaly   +8 more sources

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events [PDF]

New England Journal of Medicine, 2014
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of HDL to accept cholesterol from macrophages, which is a key step in reverse cholesterol transport.
Anand, Rohatgi, Amit, Khera, Jarett D, Berry, Edward G, Givens, Colby R, Ayers, Kyle E, Wedin, Ian J, Neeland, Ivan S, Yuhanna, Daniel R, Rader, James A, de Lemos, Philip W, Shaul   +10 more
openaire   +4 more sources

Psoriasis alters HDL composition and cholesterol efflux capacity[S] [PDF]

Journal of Lipid Research, 2012
Psoriasis, a chronic inflammatory skin disease, has been linked to increased myocardial infarction and stroke. Functional impairment of HDL may contribute to the excess cardiovascular mortality of psoriatic patients. However, data available regarding the
Michael Holzer, Peter Wolf, Sanja Curcic, Ruth Birner-Gruenberger, Wolfgang Weger, Martin Inzinger, Dalia El-Gamal, Christian Wadsack, Akos Heinemann, Gunther Marsche   +9 more
doaj   +3 more sources

Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy [PDF]

Atherosclerosis Plus, 2022
Background and aims: Preeclampsia (PE) is associated with life-long increased risk of cardiovascular disease. One of the main protective functions of high-density lipoprotein (HDL) is its role in reverse cholesterol transport.
Maaike Kockx, Lynne Roberts, Jeffrey Wang, Collin Tran, Mark A. Brown, Leonard Kritharides   +5 more
doaj   +2 more sources

The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity [PDF]

Cardiovascular Diabetology, 2018
Background It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride.
Mengdie Luo, Ziyu Zhang, Yani Peng, Shuai Wang, Daoquan Peng   +4 more
doaj   +3 more sources

Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis [PDF]

Journal of Lipid Research, 2012
High LDL-cholesterol (LDL-C) characterizes familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH). LDL-apheresis, used in these patients to reduce LDL-C levels, has been shown to also affect HDL levels and composition.
M.P. Adorni, F. Zimetti, M. Puntoni, F. Bigazzi, F. Sbrana, F. Minichilli, F. Bernini, N. Ronda, E. Favari, T. Sampietro   +9 more
doaj   +4 more sources

SAA: a link between cholesterol efflux capacity and inflammation?1 [PDF]

Journal of Lipid Research, 2015
Serum amyloid A (SAA) concentration in plasma increases markedly following infl ammation or infection, with the liver being the principal site of its synthesis. SAA was fi rst reported to be associated with both human and animal HDLs in the late 1970s ( 1 ), but is also associated with other lipoprotein fractions ( 2 , 3 ).
Michael J. Thomas, Mary G. Sorci-Thomas
doaj   +3 more sources

Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality

Biomedicines, 2022
Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD).
Andreas Ritsch, Monika Hunjadi, Tatjana Stojakovic, Jürgen E. Scherberich, Günther Silbernagel, Hubert Scharnagl, Graciela E. Delgado, Marcus E. Kleber, Winfried März   +8 more
doaj   +1 more source

Cholesterol Efflux Capacity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
High-density lipoprotein cholesterol (HDL-C) levels represent a robust and well-integrated biomarker of cardiovascular risk. The prevalence of low HDL-C is high and likely to increase in coming years in parallel with the epidemic of obesity and type 2 diabetes mellitus.
Amit V, Khera, Daniel J, Rader
openaire   +2 more sources

Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL [PDF]

Current Opinion in Lipidology, 2015
Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects.We review recent evidence that HDL's cholesterol efflux capacity is a strong ...
Patrick M, Hutchins, Jay W, Heinecke
openaire   +2 more sources