Results 81 to 90 of about 80,716 (308)

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions [PDF]

, 2015
BACKGROUND: Mycobacteria inhabit diverse niches and display high metabolic versatility. They can colonise both humans and animals and are also able to survive in the environment.
A Mitchell, AA Alatoom, AJ Pompeani, AM McGuire, Ashima Singla, C Cole, D Goeke, F Frenois, F Frenois, G Beckers, J Engohang-Ndong, JA Ibarra, JD Thompson, JE Galagan, JR Bolla, K Rutherford, L Aravind, L Cuthbertson, L Cuthbertson, L Liu, L McMurry, LG Dover, M de la Paz Santangelo, M Weigoldt, MA Behr, MA Schumacher, Mahmudul Hasan Sikder, Mike Withers, MP Santangelo, NK Dutta, NM Nesbitt, P Golby, R Brosch, R Geize Van der, Ricardo J. C. Balhana, RJ Balhana, S Hirano, S Moller, Sharon L. Kendall, SK Ahn, SL Kendall, SL Kendall, TC Galvao, TL Bailey, V Vindal, Z Yu   +45 more
core   +3 more sources

Molecular Mechanisms of Cellular Cholesterol Efflux [PDF]

Journal of Biological Chemistry, 2014
Most types of cells in the body do not express the capability of catabolizing cholesterol, so cholesterol efflux is essential for homeostasis. For instance, macrophages possess four pathways for exporting free (unesterified) cholesterol to extracellular high density lipoprotein (HDL). The passive processes include simple diffusion via the aqueous phase
openaire   +2 more sources

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Exchange and mass efflux of cholesterol in macrophages. Evidence for a common mechanism and a role for plasma membrane proteins.

Journal of Lipid Research, 1987
Exchange and net mass efflux of cholesterol were investigated in [3H]cholesterol-labeled or cholesteryl ester-loaded murine peritoneal macrophages, respectively.
R K Randolph, H F Hoff
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux

Journal of Lipid Research, 1999
The extent to which cholesterol synthesis is modulated in macrophage foam cells by changes in cholesterol influx and efflux was determined using thioglycollate-elicited peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show ...
Brian K. Nordskog, Jerry W. Reagan, Jr., Richard W. St. Clair   +2 more
doaj   +1 more source

Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice [PDF]

, 2016
Background: The average population age is increasing and the incidence of age-related vascular complications is rising in parallel. Impaired wound healing and disordered ischemia-mediated angiogenesis are key contributors to age-impaired vascular ...
Bursill, Christina A., Lam, Yuen Ting, Ng, Martin K. C., Ridiandries, Anisyah, Robertson, Stacy, Tan, Joanne T. M., Tsatralis, Tania, Vanags, Laura Z.   +7 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Familial hypercholesterolaemia: cholesterol efflux and coronary disease [PDF]

European Journal of Clinical Investigation, 2016
AbstractBackgroundCoronary heart disease (CHD) risk inversely associates with levels of high‐density lipoprotein cholesterol (HDL‐C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.Materials and methodsWe compared plasma cholesterol efflux capacity between male familial ...
Jorie Versmissen, Ranitha Vongpromek, Reyhana Yahya, Jeroen B. van der Net, Leonie van Vark‐van der Zee, Jeannette Blommesteijn‐Touw, Darcos Wattimena, Trinet Rietveld, Clive R. Pullinger, Christina Christoffersen, Björn Dahlbäck, John P. Kane, Monique Mulder, Eric J. G. Sijbrands   +13 more
openaire   +4 more sources