Results 311 to 320 of about 22,660,301 (380)

Human apolipoprotein A-I forms thermally stable complexes with anionic but not with zwitterionic phospholipids.

, 1986
Witold K. Surewicz, Richard M. Epand, Henry J. Pownall, S. W. Hui   +3 more
openalex   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

The cardio-metabolic protein profile is associated with development of type 2 diabetes at long term follow-up after gestational diabetes mellitus: Results from the OGFUS study. [PDF]

Diabetes Obes Metab
Hallig SJ, Aalders J, Christensen MH, Andersen MS, Vinter CA, Dunne F, Højlund K, Jensen DM, Overgaard M.   +8 more
europepmc   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

The Potential Causal Association of Apolipoprotein A and B and Age-Related Macular Degeneration: A Mendelian Randomisation Study. [PDF]

Biomedicines
Lee Y, Seo JH.
europepmc   +1 more source

Elevated Triglyceride‐Glucose Index Is Associated With Insulin Resistance, Metabolic Syndrome Components, Nonalcoholic Fatty Liver Disease, and Adverse Pregnancy Outcomes in Chinese Women With Polycystic Ovary Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Aim To investigate the associations of triglyceride‐glucose index (TyG) with anthropometric characteristics, metabolic/endocrine profiles, and pregnancy outcomes in Chinese women with polycystic ovary syndrome (PCOS). Methods This secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial ...
Jiaxing Feng, Rong Luo, Jingshu Gao, Yu Wang, Jing Cong, Hongli Ma, Xiaoke Wu   +6 more
wiley   +1 more source

Activating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress. [PDF]

J Biol Chem
Encarnacion J, Smith DM, Choi J, Scafidi J, Wolfgang MJ.   +4 more
europepmc   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition. [PDF]

Sci Rep
Di Biase E, Connolly KJ, Crumpton I, Cooper O, Hallett PJ, Isacson O.   +5 more
europepmc   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source